Superior restoration of left ventricular performance after prolonged single-dose del Nido cardioplegia in conjunction with terminal warm blood cardioplegic reperfusion

Nakao, Mitsutaka; Morita, Kiyozo; Shinohara, Gen; Saito, Shōgo; Kunihara, Takashi

doi:10.1016/j.jtcvs.2020.11.152

Cited by 12 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been shown that rapid myocardial recovery [Li 2018] and providing spontaneous sinus rhythm can be achieved with terminal warm blood cardioplegia used in blood cardioplegia. In an animal study, spontaneous sinus rhythm was achieved with the addition of terminal hot blood cardioplegia to a single dose of del Nido cardioplegia [Nakao 2020]. In prolonged ischemia and in high-risk patients, myocardial recovery may be delayed, due to increased inotrope support and preload in the early period after bypass.…”

Section: Discussionmentioning

confidence: 99%

Effects of Del Nido and Terminal Warm Blood Cardioplegia on Myocardial Protection and Rhythm in Isolated CABG Patients

Karaarslan

Abud

2021

HSF

View full text Add to dashboard Cite

Objective: To investigate the effect of using del Nido cardioplegia+terminal hot-shot blood cardioplegia on myocardial protection and rhythm in isolated coronary bypass patients. Material and methods: A total of 122 patients were given cold (+4-8C') del Nido cardioplegia antegrade and evaluated. Del Nido+terminal warm blood cardioplegia (TWBCP) was applied to 63 patients out of 122 patients, while del Nido cardioplegia alone was applied to the other 59 patients. The preoperative and postoperative data of the patients were recorded and compared. Results: There was a significant statistical difference between the groups, in terms of volume with more cardioplegia in the del Nido+terminal warm blood cardioplegia group. Although there was no significant difference between cardiac arrest times in both groups, a statistically significant difference was found in the del Nido+terminal warm blood cardioplegia group in the starting to work time of the heart. No difference found between the groups regarding myocardial preservation. Conclusions: We can add a return to spontaneous sinus rhythm to the advantages of terminal warm blood cardioplegia and del Nido cardioplegia in literature. We think it would be a good strategy to extend the safe ischemic time limit of del Nido to 120 minutes with a terminal warm blood cardioplegia. It seems that cardioplegia techniques that will be developed by adding the successful and superior results of crystalloid cardioplegia applications, such as single dose del Nido in various open heart surgery operations and the superior myocardial return effects of terminal warm blood cardioplegia, will be used routinely in the future.

show abstract

Section: Discussionmentioning

confidence: 99%