Superior Sagittal Sinus Thrombosis as the Initial Presentation of Renal Cell Carcinoma

Reddy, Manoj; Gross, Lara M.; Moreland, Amber; DeMarco, Daniel C.

doi:10.1080/08998280.2015.11929239

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…In many situations, meningeal carcinomatosis does not appear in imaging studies, and it may have been the cause of IH in the present case. In addition, malignant carcinoma tends to induce the hypercoagulable state, leading to cerebral venous sinus stenosis, [ 47 , 48 ] and this may have been the cause of IH in the present case. Magnetic resonance venography or cerebral digital subtraction angiography could have confirmed this possibility, but we did not perform these tests.…”

Section: Discussionmentioning

confidence: 86%

Intracranial hypertension as the primary symptom of gastric signet-ring cell carcinoma

Xu²,

Yin³

et al. 2016

Medicine

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Section: Discussionmentioning

confidence: 86%

Intracranial hypertension as the primary symptom of gastric signet-ring cell carcinoma

Xu²,

Yin³

et al. 2016

Medicine

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“…The pathogenesis of CVST in such patients remained unknown. In 2015, Reddy et al [23] reported a patient of 68-year-old man with clear cell renal carcinoma that was initially hospitalized for superior sagittal sinus thrombosis without risk factors for CVST or intracranial metastasis. As elevated plasma D-dimer meaning a hypercoagulable state [25] and with elevated plasma D-dimer, cancer-related hypercoagulability was suspected to be associated with the occurrence of CVST.…”

Section: Discussionmentioning

confidence: 99%

A clinical research on the potential pathogenesis of somatic cancer related cerebral venous sinus thrombosis

Xian

Chen

et al. 2019

Medicine

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To investigate the pathogenesis of somatic solid cancer-related cerebral venous sinus thrombosis (CVST). A total of 174 patients with CVST were recruited from the hospital between January 2006 and December 2017 and divided into two groups: (1) somatic cancer-related CVST group, defined as active somatic solid cancer patients with acute CVST; (2) cancer group (CG), defined as active somatic solid cancer patients without CVST. The cancer group patients were age and gender-matched somatic cancer-related CVST group patients. In addition, the types and amount distribution of cancer in cancer group were also matched with somatic cancer-related CVST group patients. Compared to cancer group patients, somatic cancer-related CVST group patients had more intracranial metastasis, a higher platelet count, higher plasma D-dimer, carcinoembryonic antigen (CEA) and cancer antigen (CA) 125 levels, a greater platelet to lymphocyte ratio (PLR), and a greater platelet to neutrophil ratio (PNR). The risk for CVST in somatic cancer-related CVST group patients increased independently by 0.7% (odds ratio [OR] 1.007; 95% confidence interval [CI] 1.000, 1.015; P = .047) with a 1 ng/ml increase in D-dimer levels, by 4.6% (OR 1.046; 95% CI 1.011, 1.083; P = .010) with a 1 U/ml increase in CEA, by 2.7% (OR 1.027; 95% CI 1.003, 1.051; P = .025) with a 1 U/ml increase in CA125, and by 10.6% (OR 1.106; 95% CI 1.002, 1.220; P = .045) with a 1 unit increase in PNR. It was suggested that together impacts of elevated plasma D-dimer, CA125, CEA levels, and a greater PNR may lead to hypercoagulability and to trigger the development of cancer-related CVST.

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Superior Sagittal Sinus Thrombosis as the Initial Presentation of Renal Cell Carcinoma

Cited by 2 publications

References 10 publications

Intracranial hypertension as the primary symptom of gastric signet-ring cell carcinoma

Intracranial hypertension as the primary symptom of gastric signet-ring cell carcinoma

A clinical research on the potential pathogenesis of somatic cancer related cerebral venous sinus thrombosis

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