Superior Valorisation of Juglans regia L. Leaves of Different Maturity through the Isolation of Bioactive Compounds

Tociu, Mihaela; Manolache, Fulvia; Bălănucă, Brîndușa; Moroșan, Alina; Stan, Raluca

doi:10.3390/molecules28217328

Cited by 2 publications

(1 citation statement)

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“…According to Medic et al [35], who performed the extraction of 0.25 g of leaf powder with methanol in an extract ratio of 1:30 (w/v) leaves: methanol using ultrasonication for 60 min and analyzed the extracts via HPLC-MS, and other research [36][37][38][39][40][41][42], walnut leaves contain a large amount of compounds from the class of hydroxycinnamic acids (neochlorogenic acid and 3-p-coumaroylquinic acid), flavonoids ((+) catechin, procyanidin dimers, and quercetin derivatives), and naphthoquinones (hydrojuglone derivatives, juglone, and sdihydroxytetralone hexoside) (Table 2). Green walnut shell extracts can be obtained using several extraction methods.…”

Section: Chemical Composition Of Walnut Leavesmentioning

confidence: 99%

Walnut By-Products and Elderberry Extracts—Sustainable Alternatives for Human and Plant Health

Sandu-Bălan (Tăbăcariu),

Ifrim,

Patriciu

et al. 2024

Molecules

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A current alternative for sustainable development through green chemistry is the replacement of synthetic compounds with natural ones through the superior capitalization of natural resources, with numerous applications in different fields. The benefits of walnuts (Juglans regia L.) and elderberries (Sambucus nigra L.) have been known since ancient times, due to the presence of phytochemicals such as flavonoids, polyphenols, carotenoids, alkaloids, nitrogen-containing compounds, tannins, steroids, anthocyanins, etc. These active compounds have multiple biological activities for human health, including benefits that are antibacterial, antioxidant, anti-inflammatory, antidiabetic, hepatoprotective, antihypertensive, neuroprotective, etc. Like other medicinal plants, the walnut and the elderberry possess important phytosanitary properties (antibacterial, antifungal, and insecticidal) and their extracts can also be used as environmentally safe biopesticides, with the result that they constitute a viable and cheap alternative to environmentally harmful synthetic products. During recent years, walnut by-products and elderberries have attracted the attention of researchers, and investigations have focused on the species’ valuable constituents and active properties. Comparing the information from the literature regarding the phytochemical profile and biological activities, it is highlighted that, apart from the predominant specific compounds, the walnut and the elderberry have common bioactive compounds, which come from six classes (phenols and derivatives, flavonoids, hydroxycinnamic acids, tannins, triterpenoids, and phytosteroids), and act on the same microorganisms. From this perspective, the aim of this review is to provide an overview of the bioactive compounds present in the different constitutive parts of walnut by-products and elderberries, which present a specific or common activity related to human health and the protection of agricultural crops in the context of sustainable development.

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