Superior vena cava syndrome as a paraneoplastic manifestation of soft tissue sarcoma

Ghorbani, Hossein; Sadeghi, Mohsen Vakili; Hejazian, Tahereh; Sharbatdaran, Majid

doi:10.1016/j.htct.2017.09.001

Cited by 6 publications

(5 citation statements)

References 10 publications

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“…8 Chronic SVCS may present as distention of collateral veins, which may be observed in upper chest. 9 Collateral vein distention in upper chest was present in this case, hence this case is a chronic SVCS case. This is consistent with patient's history.…”

Section: Discussionmentioning

confidence: 58%

“…Corticosteroid was given to decrease swelling and dyspnea. 9 Corticosteroid may also reduce tumor load. Administration of corticosteroid relieves respiratory distress and reverses swellings on the face within 48 hours.…”

Section: Discussionmentioning

confidence: 99%

“…Goal of this manuever is to reduce hydrostatic pressure in upper half of body. 9 Diuretic was given to normalize blood pressure, and to decrease swelling and dyspnea. Diuretic use for SVCS management is still a matter of debate.…”

Section: Discussionmentioning

confidence: 99%

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Superior vena cava syndrome management in limited source setting: a case report

Setiawan¹,

Sunaka²,

Yaniswari³

2022

Int J Adv Med

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Superior vena cava syndrome (SVCS) is syndrome caused by mass compression, tumor invasion, and/or thrombosis of SVC. In the past, SVCS was mostly linked to infection. Nowadays, SVCS is mostly linked to malignant tumor and medical procedures. Most common malignant cause of SVCS is non small cell lung cancer. A 69-year-old man was presented with breathing difficulty. Symptom began 4 months before admission, with worsening of symptom since 2 weeks before admission. Symptom improved with sitting position, and worsened with supine position. Patient had been sleeping with 2 pillows. Patient had productive cough and hoarseness. Swelling of face and neck were present. Collateral vein distention was visible in the area of head, neck, and chest. Physical examination of lung revealed decreased vesicular breath sound at right side. Non pitting edema was found at both sides of upper extremity. SVCS in this case can be categorized into grade 2, chronic SVCS case. CT showed center right lung mass, although malignant cells were not obtained from pleural puncture and CT guided needle biopsy. Staging of mass was T4N3M1a. Mass finding at the center of right lung is in accordance with the previous findings that SVCS generally arise from lung (not mediastinum), and that right sided masses are generally more likely to cause SVCS. Management in this case was done by giving corticosteroid and diuretic. Surgery, radiotherapy, and immunotherapy were not done since malignancy diagnosis hadn’t been able to be concluded.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

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Superior vena cava syndrome management in limited source setting: a case report

Setiawan¹,

Sunaka²,

Yaniswari³

2022

Int J Adv Med

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“…The increase in the use of catheters, pacemakers and implantable cardioverter defibrillator (ICD) leads have contributed to this. This results in fibrosis, inflammation of the venous wall, and eventually, stenosis of the SVC 8–10…”

Section: Discussionmentioning

confidence: 99%

Sore throat turned to be a bronchogenic carcinoma with superior vena cava syndrome

et al. 2019

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Superior vena cava (SVC) syndrome is a group of symptoms caused by complete or partial obstruction of the flow of blood through the SVC. The obstruction is, in most cases, caused by the formation of thrombus or infiltration of a tumour through the vessel wall. The result is venous congestion that creates a clinical situation relating to increase in the venous pressure in the upper part of the body. Symptoms commonly associated with vena cava syndrome include cough, dyspnoea, swelling of the neck, face and the upper extremities and dilation of the chest vein collaterals. In this paper, we examine the case of a 50-year-old man who presented to the emergency department with ‘sore throat’ which can be easily misdiagnosed as a case of uncomplicated acute pharyngitis. It was a real challenge to diagnose our patient as SVC syndrome caused by bronchogenic carcinoma.

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“…Thrombotic etiology of SVC syndrome has been recently reported to be on the rise due to an increased usage of intravascular devices, which are known to increase the risk of thrombotic events [ 1 , 2 ]. Spontaneous thrombosis of the SVC has also been reported in patients with hypercoagulable states or malignancies as a paraneoplastic manifestation [ 8 , 9 , 10 , 11 , 12 ]. While sarcoidosis has been associated with hypercoagulation [ 13 ], SVC syndrome caused by venous thrombosis in the setting of sarcoidosis, cancer, and a venous catheter has not been reported previously.…”

Section: Introductionmentioning

confidence: 99%

Recurrent Superior Vena Cava Syndrome in a Patient with Sarcoidosis and Pancreatic Adenocarcinoma: A Case Report and Literature Review

et al. 2020

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Background: Superior vena cava (SVC) syndrome may result from extravascular compression or intravascular obstruction such as thrombosis. Recurrent venous thrombosis is typically associated with a hypercoagulable state such as malignancy, and inheritable or acquired coagulopathy. Sarcoidosis is a derangement of the immune system, and it has been associated with malignant diseases and hypercoagulation. The association of pancreatic cancer and sarcoidosis with SVC syndrome has not been reported previously. Here, we present a case of recurrent venous thrombosis causing SVC syndrome in a patient with pancreatic ductal adenocarcinoma and underlying thoracic sarcoidosis. Methods: The patient’s electronic health record was retrospectively analyzed. Results: A 66-year-old woman with pancreatic adenocarcinoma was treated with neoadjuvant chemotherapy followed by Whipple procedure, before developing tumor recurrence in the liver. Her treatment course was complicated with repeated incidents of venous thrombosis in the presence of a central venous catheter leading to recurrent SVC syndrome, which resolved with anti-coagulation. Conclusions: This case raises a plausible inter-relationship between sarcoidosis, pancreatic cancer, and hypercoagulable state. We suggest that patients with multiple risk factors for developing venous thrombosis should be carefully monitored for any thrombotic event, and they may benefit from prophylactic anti-coagulation.

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Superior vena cava syndrome as a paraneoplastic manifestation of soft tissue sarcoma

Cited by 6 publications

References 10 publications

Superior vena cava syndrome management in limited source setting: a case report

Superior vena cava syndrome management in limited source setting: a case report

Sore throat turned to be a bronchogenic carcinoma with superior vena cava syndrome

Recurrent Superior Vena Cava Syndrome in a Patient with Sarcoidosis and Pancreatic Adenocarcinoma: A Case Report and Literature Review

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