Superiority of C-11 acetate compared with F-18 fluorodeoxyglucose in predicting myocardial functional recovery by positron emission tomography in patients with acute myocardial infarction

Rubin, Patricia J.; Lee, Dong Hoon; Dávila‐Román, Víctor G.; Geltman, Edward M.; Schechtman, Kenneth B.; Bergmann, Steven R.; Gropler, Robert J.

doi:10.1016/s0002-9149(96)00601-7

Cited by 39 publications

(7 citation statements)

References 23 publications

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“…11 C-acetate has also been applied in humans to identify hibernating myocardium. Gropler et al, in a series of studies, compared the use of 11 C-acetate (marker of oxidative metabolism) with 18 F-FDG as a predictor of functional recovery after revascularization in patients with LV dysfunction attributable to CAD [76][77][78]. He observed that estimates of oxidative metabolism by 11 C-acetate yielded higher positive and negative predictive values in predicting myocardial functional recovery than 18 F-FDG and hypothesized that 18 F-FDG uptake in the chronically hypoperfused myocardium is predictive of functional recovery only when the metabolic pattern is accompanied by significant oxidative metabolism from glucose [76][77][78].…”

Section: Cardiac Metabolism Assessment With Petmentioning

confidence: 99%

The Role of Cardiac PET in Translating Basic Science into the Clinical Arena

Bravo

Bengel

2011

J. of Cardiovasc. Trans. Res.

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Non-invasive imaging has become fundamental in translating findings from basic science research into clinical applications. In this aspect, positron-emission tomography (PET) offers important advantages over other common imaging modalities like single-photon emission computed tomography, computed tomography, and magnetic resonance imaging (MRI), since PET provides superior detection sensitivity in the evaluation of different cardiovascular targets and pathways at the cellular and subcellular level, and because it is a well-established technique for absolute image quantification. The development and the introduction of dedicated small animal PET systems have greatly facilitated and contributed to advancements in the translation of novel radio-labeled compounds from experimental to clinical practice. The scope of the present article is to review the most relevant and successful PET applications in cardiovascular translational research.

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Section: Cardiac Metabolism Assessment With Petmentioning

confidence: 99%

The Role of Cardiac PET in Translating Basic Science into the Clinical Arena

Bravo

Bengel

2011

J. of Cardiovasc. Trans. Res.

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“…Change of the cardiac substrate metabolism over time seems to be the most reliable hall mark of acute coronary events [1][2][3]. By performing repeated 11 C acetate studies, physicians can assess the evolution of the heart's oxidative metabolism, and this considered to be the only significant predictor of functional recovery after reperfusion of an acute myocardial infarction (AMI) [1].…”

Section: Introductionmentioning

confidence: 99%

The washout rate of 123I-BMIPP and the evolution of left ventricular function in patients with successfully reperfused ST-segment elevation myocardial infarction: comparisons with the echocardiography

Biswas

Sarai

Yamada

et al. 2010

Int J Cardiovasc Imaging

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The evolution of the oxidative metabolism of (11)C acetate parallels the recovery of left ventricular(LV) contraction following acute myocardial infarction(AMI). This study was designed to unravel, for the first time, the impact of the global washout rate(WR) of (123)I-beta-methyl-p-iodophenylpentadecanoic acid (BMIPP) on the recovery of LV function followingAMI, as evidenced from conventional echocardiography.Twenty consecutive patients (age: 58 +/- 13 years; 16 males and 4 females) with ST-segment elevation myocardial infarction (STEMI) were enrolled and all of them underwent successful percutaneous coronary intervention (PCI). (123)I-BMIPP cardiac scintigraphy was performed at 7 +/- 3 days after admission. The WR was calculated from the polar map and the regional BMIPP defect score was calculated using a 17 segment model. Echocardiography was performed within 24 h of admission and at 3 months to record the ejection fraction (EF), the wall motion score index (WMSI), the ratio of the mitralinflow velocity to the early diastolic velocity (E/E0)and the myocardial performance index (MPI). The mean global WR of the BMIPP was 22.12 +/- 7.22%, and it was significantly correlated with the improvement of the WMSI (r = 0.61, P\0.004). However,the relative changes of the EF, E/E0 and MPI were not correlated with the WR. The BMIPP defect score (18 +/- 10) was significantly correlated with the WMSI on admission (r = 0.74, P = 0.0002), but the defect score was not correlated with the relative changes of any of the echocardiographic parameters. We proved that the WR of the BMIPP is a promising indicator of improvement of the LV wall motion (WMSI) following ST-segment elevation myocardial infarction and successful reperfusion.

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“…C-11 acetate PET enables quantification of both regional blood flow and oxidative metabolism. In patients with acute myocardial infarction, measurements of myocardial oxidative metabolism by C-11 acetate more accurately predicted myocardial functional recovery after coronary revascularization than did assessments of overall glucose metabolism by 18 F-FDG PET [86]. In patients with acute myocardial infarction, measurements of myocardial oxidative metabolism by C-11 acetate more accurately predicted myocardial functional recovery after coronary revascularization than did assessments of overall glucose metabolism by 18 F-FDG PET [86].…”

Section: F-fdgmentioning

confidence: 95%

Cardiac applications of PET

Sarıkaya¹

2015

Nuclear Medicine Communications

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Routine use of cardiac positron emission tomography (PET) applications has been increasing but has not replaced cardiac single-photon emission computerized tomography (SPECT) studies yet. The majority of cardiac PET tracers, with the exception of fluorine-18 fluorodeoxyglucose (18F-FDG), are not widely available, as they require either an onsite cyclotron or a costly generator for their production. 18F-FDG PET imaging has high sensitivity for the detection of hibernating/viable myocardium and has replaced Tl-201 SPECT imaging in centers equipped with a PET/CT camera. PET myocardial perfusion imaging with various tracers such as Rb-82, N-13 ammonia, and O-15 H2O has higher sensitivity and specificity than myocardial perfusion SPECT for the detection of coronary artery disease (CAD). In particular, quantitative PET measurements of myocardial perfusion help identify subclinical coronary stenosis, better define the extent and severity of CAD, and detect ischemia when there is balanced reduction in myocardial perfusion due to three-vessel or main stem CAD. Fusion images of PET perfusion and CT coronary artery calcium scoring or CT coronary angiography provide additional complementary information and improve the detection of CAD. PET studies with novel 18F-labeled perfusion tracers such as 18F-flurpiridaz and 18F-FBnTP have yielded high sensitivity and specificity in the diagnosis of CAD. These tracers are still being tested in humans, and, if approved for clinical use, they will be commercially and widely available. In addition to viability studies, 18F-FDG PET can also be utilized to detect inflammation/infection in various conditions such as endocarditis, sarcoidosis, and atherosclerosis. Some recent series have obtained encouraging results for the detection of endocarditis in patients with intracardiac devices and prosthetic valves. PET tracers for cardiac neuronal imaging, such as C-11 HED, help assess the severity of heart failure and post-transplant cardiac reinnervation, and understand the pathogenesis of arrhytmias. The other uncommon applications of cardiac PET include NaF imaging to identify calcium deposition in atherosclerotic plaques and β-amyloid imaging to diagnose cardiac amyloid involvement. 18F-FDG imaging with a novel PET/MR camera has been reported to be very sensitive and specific for the differentiation between malignant and nonmalignant cardiac masses. The other potential applications of PET/MR are cardiac infectious/inflammatory conditions such as endocarditis.

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Superiority of C-11 acetate compared with F-18 fluorodeoxyglucose in predicting myocardial functional recovery by positron emission tomography in patients with acute myocardial infarction

Cited by 39 publications

References 23 publications

The Role of Cardiac PET in Translating Basic Science into the Clinical Arena

The Role of Cardiac PET in Translating Basic Science into the Clinical Arena

The washout rate of 123I-BMIPP and the evolution of left ventricular function in patients with successfully reperfused ST-segment elevation myocardial infarction: comparisons with the echocardiography

Cardiac applications of PET

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