Superiority of clinical American Joint Committee on Cancer T classification for perihilar cholangiocarcinoma

Yamada, Minoru; Mizuno, Takashi; Yamaguchi, Junpei; Yokoyama, Yukihiro; Igami, Tsuyoshi; Onoe, Shunsuke; Watanabe, Nozomi; Uehara, Kay; Matsuo, Keitaro

doi:10.1002/jhbp.1066

Cited by 2 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It included patients with various backgrounds, and the metastatic frequency to the LN stations and the OS rate might have been affected by pT classifications and multiple perioperative factors. 34,35 The posterior pancreaticoduodenal LN caudal to the duodenal papilla was not dissected in the PHCC group, and the para-aortic LN was sampled and not systematically dissected in all patients; therefore, the frequency of metastasis in these LN stations might be underestimated. Because of the limited number of patients with metastasis in the posterior pancreaticoduodenal LN and para-aortic LN in the PHCC group, and in LN along the CHA, LN along the SMA, and para-aortic LN in the DCC group, the results of these analyses may not have reached sufficient reliability.…”

Section: Discussionmentioning

confidence: 99%

“…This study had some limitations. It included patients with various backgrounds, and the metastatic frequency to the LN stations and the OS rate might have been affected by pT classifications and multiple perioperative factors 34,35 . The posterior pancreaticoduodenal LN caudal to the duodenal papilla was not dissected in the PHCC group, and the para‐aortic LN was sampled and not systematically dissected in all patients; therefore, the frequency of metastasis in these LN stations might be underestimated.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Benefit of lymph node dissection for perihilar and distal cholangiocarcinoma according to lymph node stations

Terasaki,

Sugiura,

Okamura

et al. 2023

J Hepato Biliary Pancreat

Self Cite

View full text Add to dashboard Cite

BackgroundThe benefits of lymph node (LN) dissection at each station have not previously been fully investigated in perihilar cholangiocarcinoma (PHCC) and distal cholangiocarcinoma (DCC).MethodsThe efficacy index (EI) was calculated in patients who underwent surgery for PHCC (n = 134) and DCC (n = 135) by multiplying the frequency of metastasis to the LN station and the 5‐year overall survival (OS) rate of patients with metastasis to that station.ResultsIn PHCC, the frequency of metastasis, 5‐year OS rates, and the EI in para‐aortic LNs (4.7%, 0%, and 0, respectively) and posterior pancreaticoduodenal LNs (8.1%, 0%, and 0, respectively) were lower than those in hepatoduodenal ligament LNs (30.1%, 24.1%, and 7.25, respectively) and LNs along the common hepatic artery (CHA) (16.2%, 15.0%, and 2.43, respectively). In DCC, these values were lower in LNs along the CHA (6.4%, 0%, and 0, respectively) than in the posterior pancreaticoduodenal LNs (31.2%, 34.5%, and 10.8, respectively), the hepatoduodenal ligament LNs (14.8%, 15.2%, and 2.25, respectively), and para‐aortic (4.0%, 25.0%, and 0.99, respectively) LNs.ConclusionsAccording to the EI, this study raises concerns about the effectiveness of dissection in the posterior pancreaticoduodenal LNs in PHCC and LNs along the CHA in DCC.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Benefit of lymph node dissection for perihilar and distal cholangiocarcinoma according to lymph node stations

Terasaki,

Sugiura,

Okamura

et al. 2023

J Hepato Biliary Pancreat

Self Cite

View full text Add to dashboard Cite

show abstract

“…Oncolytic viruses (OVs) selectively replicate in and kill tumor cells and can induce immune cell infiltration at tumor sites through virus-mediated inflammatory responses ( 1 , 2 ) that may reduce the immuno-inhibitory effects of the preexisting tumor microenvironment (TME) ( 2 ). To further enhance host antitumor immunity through OVs, investigators have incorporated immunomodulatory molecules into their OVs (“Armed” OVs), which demonstrated additive antitumor effects in preclinical and clinical studies ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Ultralow-dose binary oncolytic/helper-dependent adenovirus promotes antitumor activity in preclinical and clinical studies

et al. 2023

View full text Add to dashboard Cite

We show that a binary oncolytic/helper-dependent adenovirus (CAdVEC) that both lyses tumor cells and locally expresses the proinflammatory cytokine IL-12 and PD-L1 blocking antibody has potent antitumor activity in humanized mouse models. On the basis of these preclinical studies, we treated four patients with a single intratumoral injection of an ultralow dose of CAdVEC (NCT03740256), representing a dose of oncolytic adenovirus more than 100-fold lower than used in previous trials. While CAdVEC caused no significant toxicities, it repolarized the tumor microenvironment with increased infiltration of CD8 T cells. A single administration of CAdVEC was associated with both locoregional and abscopal effects on metastases and, in combination with systemic administration of immune checkpoint antibodies, induced sustained antitumor responses, including one complete and two partial responses. Hence, in both preclinical and clinical studies, CAdVEC is safe and even at extremely low doses is sufficiently potent to induce significant tumor control through oncolysis and immune repolarization.

show abstract

Superiority of clinical American Joint Committee on Cancer T classification for perihilar cholangiocarcinoma

Cited by 2 publications

References 32 publications

Benefit of lymph node dissection for perihilar and distal cholangiocarcinoma according to lymph node stations

Benefit of lymph node dissection for perihilar and distal cholangiocarcinoma according to lymph node stations

Ultralow-dose binary oncolytic/helper-dependent adenovirus promotes antitumor activity in preclinical and clinical studies

Contact Info

Product

Resources

About