Superiority of gentle VS sudden reperfusion during relief of coronary occlusion

Okamoto, Fumiyuki; Allen, Bradley S.

doi:10.1016/s0022-2828(86)80697-6

Cited by 53 publications

(65 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…While the gradual reperfusion can attenuate the deleterious effects after ischemia, abrupt reperfusion has been shown not only increase of the incidence of reperfusion arrhythmias [15] and worsening of ventricular dysfunction [16.17], but also favoring the development of irreversible injury [18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Efeitos do pós-condicionamento isquêmico na função ventricular esquerda de corações isolados de ratos

Pinheiro¹,

Fiorelli²,

Gomes³

2009

Rev Bras Cir Cardiovasc

View full text Add to dashboard Cite

Efeitos do pós-condicionamento isquêmico na função ventricular esquerda de corações isolados de ratosEffects of ischemic postconditioning on left ventricular function of isolated rat hearts Abstract Objective: To assess the effects of ischemic postconditioning on left ventricular function in isolated rat hearts.Methods: Twenty-four Wistar rats were used. These hearts underwent perfusion by modified LANGERDORFF method and distributed into three groups: GI -control (n=8); GII -three cycles of postconditioning of 10/10s (n=8); GIIIthree cycles of postconditioning of 30/30s (n=8). After a 15min stabilization period, all hearts underwent 20min of global ischemia following 20min of reperfusion. In the times 0 (control), 5, 10, 15 and 20min of reperfusion, the heart rate (HR), the coronary flow (CoF), the systolic pressure, the (+dP/dt max) contractility and (-dP/dt max) velocity of relaxation were measured. Data were analyzed by ANOVA method followed by Tukey's test for differences between groups and P < 0.05 was considered significant. Rev Bras Cir Cardiovasc 2009; 24(1): 31-37

show abstract

Section: Discussionmentioning

confidence: 99%

Efeitos do pós-condicionamento isquêmico na função ventricular esquerda de corações isolados de ratos

Pinheiro¹,

Fiorelli²,

Gomes³

2009

Rev Bras Cir Cardiovasc

View full text Add to dashboard Cite

show abstract

“…For instance, while gradual reperfusion may attenuate deleterious effects, abrupt reperfusion has been shown not only to increase the incidence of reperfusion arrhythmias (9) and aggravate stunning (16), but even to contribute to the development of irreversible damage (1,5,25,26). Zhao et al (39) reported recently that abrupt reperfusion after a sustained coronary artery occlusion (CAO) can also limit irreversible damage, provided that this was interrupted by a number of brief periods of abrupt coronary artery reocclusion and abrupt reperfusion started within 30 s after the initial abrupt reperfusion.…”

mentioning

confidence: 99%

Cardiac effects of postconditioning depend critically on the duration of index ischemia

Manintveld

Hekkert²,

Bos³

et al. 2007

American Journal of Physiology-Heart and Circulatory Physiology

100

View full text Add to dashboard Cite

Postconditioning (POC) is known as the phenomenon whereby brief intermittent ischemia applied at the onset of reperfusion following index ischemia limits myocardial infarct size. Whereas there is evidence that the algorithm of the POC stimulus is an important determinant of the protective efficacy, the importance of the duration of index ischemia on the outcome of the effects of POC has received little attention. Pentobarbital sodiumanesthetized Wistar rats were therefore subjected to index ischemia produced by coronary artery occlusions (CAO) of varying duration (15-120 min) followed by reperfusion, without or with postconditioning produced by three cycles of 30-s reperfusion and reocclusion (3POC30). 3POC30 limited infarct size produced by 45-min CAO (CAO45) from 45 Ϯ 3% to 31 Ϯ 5%, and CAO60 from 60 Ϯ 3% to 47 Ϯ 6% (both P Յ 0.05). In contrast, 3POC30 increased infarct size produced by CAO15 from 3 Ϯ 1% to 19 Ϯ 6% and CAO30 from 36 Ϯ 6 to 48 Ϯ 4% (both P Յ 0.05). This deleterious effect of 3POC30 was not stimulus sensitive because postconditioning with 3POC5 and 3POC15 after CAO30 also increased infarct size. The cardioprotection by 3POC30 after CAO60 was accompanied by an increased stimulation of Akt phosphorylation at 7 min of reperfusion and a 36% lower superoxide production, measured by dihydroethidium fluorescence, after 2 h of reperfusion. Consistent with these results, cardioprotection by 3POC30 was abolished by phosphatidylinositol-3-OH-kinase inhibition, as well as nitric oxide (NO) synthase inhibition. The deleterious effect of 3POC30 after CAO15 was accompanied by an increased superoxide production with no change in Akt phosphorylation and was not affected by NO synthase inhibition. In conclusion, the effect of cardiac POC depends critically on the duration of the index ischemia and can be either beneficial or detrimental. These paradoxical effects of POC may be related to the divergent effects on Akt phosphorylation and superoxide production.

show abstract

“…(32) Interestingly, modifying myocardial reperfusion by gradually reperfusing the heart had been previously reported to limit myocardial infarct size. (33,34) In fact, the term postconditioning had been previously used to refer to the antiarrhythmic effect of intermittent reperfusion in the feline heart. (35) Providing the IPost protocol is modifi ed appropriately, most animal hearts appear amenable to IPost, including human myocardium.…”

Section: Ischaemic Postconditioning: Effective Clinical Cardioprotectionmentioning

confidence: 99%

Preconditioning and postconditioning: from bench to bedside

Hausenloy

Yellon

2017

SAHJ

View full text Add to dashboard Cite

Superiority of gentle VS sudden reperfusion during relief of coronary occlusion

Cited by 53 publications

References 0 publications

Efeitos do pós-condicionamento isquêmico na função ventricular esquerda de corações isolados de ratos

Efeitos do pós-condicionamento isquêmico na função ventricular esquerda de corações isolados de ratos

Cardiac effects of postconditioning depend critically on the duration of index ischemia

Preconditioning and postconditioning: from bench to bedside

Contact Info

Product

Resources

About