Superiority of Intestinal Adaptation by Hepatocyte Growth Factor in the Jejunum: An Experimental Study in a Short-Bowel Rat Model

Sugita, Koshiro; Yano, Keisuke; Onishi, Shun; Iwamoto, Yumiko; Ogata, Masato; Takada, Lynne; Kedoin, Chihiro; Masakazu, Murakami; Harumatsu, Toshio; Kawano, Takafumi; Muto, Mitsuru; Kumagai, Kotaro; Ido, Akio; Kaji, Tatsuru; Ieiri, Satoshi

doi:10.1016/j.jpedsurg.2023.11.028

Journal of Pediatric Surgery

2024

DOI: 10.1016/j.jpedsurg.2023.11.028

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Superiority of Intestinal Adaptation by Hepatocyte Growth Factor in the Jejunum: An Experimental Study in a Short-Bowel Rat Model

Koshiro Sugita,

Keisuke Yano,

Shun Onishi

et al.

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2024

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Cited by 2 publications

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Impact of hepatocyte growth factor on the colonic morphology and gut microbiome in short bowel syndrome rat model

Sugita,

Yano,

Onishi

et al. 2024

Pediatr Surg Int

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Impact of hepatocyte growth factor on the colonic morphology and gut microbiome in short bowel syndrome rat model

Sugita,

Yano,

Onishi

et al. 2024

Pediatr Surg Int

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Favorable inhibitory effect of clodronate on hepatic steatosis in short bowel syndrome model rats

Tsuruno,

Nagano,

Sugita

et al. 2024

Pediatr Surg Int

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Purpose This study investigated the anti-inflammatory effect of clodronate, a vesicular nucleotide transporter (VNUT) inhibitor, on intestinal-failure-associated liver disease (IFALD) in a rat model of short bowel syndrome (SBS). Methods The rats underwent jugular vein catheterization for continuous total parenteral nutrition (TPN) and 90% small bowel resection. The animals were divided into the following groups: TPN/SBS (Control group), TPN/SBS/intravenous administration of low-dose clodronate (20 mg/kg twice per week; Low group), or TPN/SBS/intravenous administration of high-dose clodronate (60 mg/kg twice per week; High group). On day 7, the rats were euthanized. Hepatic steatosis and hepatocellular injury were also assessed. Results Hepatic steatosis and lobular inflammation in the liver were observed in all groups. The High group showed histologically reduced hepatic steatosis compared with the Control group. IL-6 and Nlrp3 expression in the High group was significantly suppressed compared to that in the Control group. The expression of other inflammatory cytokines tended to be lower in the High dose group than in the control group. The lipid metabolism gene expression in the liver specimens showed no significant differences among the groups. Conclusion The high-dose administration of clodronate may, therefore, inhibit hepatic steatosis and inflammation associated with IFALD in patients with SBS.

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Superiority of Intestinal Adaptation by Hepatocyte Growth Factor in the Jejunum: An Experimental Study in a Short-Bowel Rat Model

Cited by 2 publications

References 15 publications

Impact of hepatocyte growth factor on the colonic morphology and gut microbiome in short bowel syndrome rat model

Impact of hepatocyte growth factor on the colonic morphology and gut microbiome in short bowel syndrome rat model

Favorable inhibitory effect of clodronate on hepatic steatosis in short bowel syndrome model rats

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