Superiority of Pentobarbital versus Chloral Hydrate for Sedation in Infants during Imaging

Abstract

Although oral pentobarbital and oral chloral hydrate are equally effective, the incidence of adverse events with pentobarbital was significantly reduced.

Role Of Anaesthetist In Sedation For Diagnostic Procedures: The Glass Is Half Empty? A Narrative Review

“…Some studies have been designed to establish who, among the healthcare personnel, can appropriately deliver sedative drugs, which drugs to use and their route of administration in various procedures. This shift between the above-mentioned issues has favoured the technical-organizational rather than the scientificclinical issue [5,15,16]. This choice by researchers has brought more confusion and variability to the available published data and makes them difficult to compare.…”

“…Indeed, these data have been produced by different healthcare professionals utilizing different techniques. Some of them have different skills in the management of the airways, depth of sedation, hemodynamic derangement caused by drugs, and overall protection of the sedated patient [5,11,12,[15][16][17][18].…”

“…During a sedation procedure (where the main objective is to achieve the patient's immobility and, in some cases, deep analgesia) the level of confidence/experience of the operator in the utilization of sedative and analgesic drugs, together with knowledge of drug actions is crucial to patient safety; this should be the basic standard used in the future to compare techniques, drugs and modes of administration in sedative procedures [5,11,12,[15][16][17][18].…”

“…As a result, it could be argued that some drugs and techniques have not been optimally employed [5,11,12,[14][15][16][17][18].This argument is further supported by the fact that in multiple papers, complications associated with sedative procedures have been described, which necessitated help from an anesthetist [5,11,12,[14][15][16][17][18].…”

“…Even when well-trained healthcare professionals are used, their lack of specific training and experience in sedation may well have affected the results of various studies [5,11,12,[14][15][16]18].…”