Laser Therapy in the Management of Painful Temporomandibular Dysfunction: Scientific Evidence Low-intensity laser application has been described in the literature as an intervention proposal for cases of Temporomandibular Dysfunction (TMD), and scientific evidence-based action is key for a successful treatment. This research aims to identify in literature the effectiveness of laser therapy for the control of painful TMD in adults. A systematic literature review was carried out through specific search strategies tailored for each of the databases analyzed. The researcher used PICO on PubMed, Bireme, Embase, and Scopus databases by cross-referencing the descriptors from DeCS/MESH and random keywords. Clinical trials were included involving human subjects of both sexes, aged between 18 and 55 years old, who used either GaAs or AsGaAl (infrared) low-intensity laser as an intervention in the treatment of TMD. The studies included presented laser type, application parameters and settings, and the assessment tools for potential analysis of the results for the therapy protocols that were used, with independent and non-associated therapy. All participants diagnosed with painful TMD and Muscle Temporomandibular and/or Joint Dysfunction were included. Two independent reviewers selected the articles, then the data were organized by the researcher responsible for the project, and later the data were analyzed according to the information previously collected and organized. After excluding articles by reading their title and abstract and removing duplicates, 33 of those articles related to the topic were selected and, finally, five of those were chosen. The number of participants in the study ranged from 18 to 74 subjects. Amongst the five studies analyzed, three of them were conducted in Brazil. Two studies had more than one experimental group with different dosimetry in the laser application, and only one article presented another associated therapy. Regarding the TMD diagnosis, three articles used the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) as the assessment tool. The total number of sessions ranged from three to ten, with a weekly frequency of two to four times a week, which lasted from one to five weeks. Both device and dosimetry of the studies were different, but most studies presented continuous-wave laser. Only one article did not disclose such information. Application time in the experimental and placebo groups ranged from ten to sixty seconds. Four of the five articles used GaAlAs laser and one used GaAs laser. We could identify that, out of the five studies selected, four presented improvement in the painful symptoms through laser therapy and one showed results that were similar to the placebo group. However, due to the limited number of studies and variabilities in how results were assessed and presented, it was not possible to apply the statistical treatment (meta-analysis) to prove the effectiveness of laser therapy in adults with painful TMD.