Supernumerary neuromasts in the posterior lateral line of zebrafish lacking peripheral glia

López‐Schier, Hernán; Hudspeth, A. J.

doi:10.1073/pnas.0409361102

Cited by 90 publications

(102 citation statements)

References 28 publications

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“…In addition, a trail of cells extends all along the pathway (arrows in Fig. 4C), corresponding to the interneuromastic cells that later give rise to intercalary neuromasts (Grant et al, 2005;López-Schier and Hudspeth, 2005). Contrariwise, morpholino-injected embryos showed a strong reduction in the number of deposited groups of cells, parallel to the observed reduction in the number of differentiated neuromasts (Fig.…”

Section: Loss-of-function Of Tacstdmentioning

confidence: 71%

Control of cell migration in the zebrafish lateral line: Implication of the gene “Tumour-Associated Calcium Signal Transducer,”tacstd

et al. 2006

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The sensory organs of the zebrafish lateral-line system (neuromasts) originate from migrating primordia that move along precise pathways. The posterior primordium, which deposits the neuromasts on the body and tail of the embryo, migrates along the horizontal myoseptum from the otic region to the tip of the tail. This migration is controlled by the chemokine SDF1, which is expressed along the prospective pathway, and by its receptor CXCR4, which is expressed by the migrating cells. In this report, we describe another zebrafish gene that is heterogeneously expressed in the migrating cells, tacstd. This gene codes for a membrane protein that is homologous to the TACSTD1/2 mammalian proteins. Inactivation of the zebrafish tacstd gene results in a decrease in proneuromast deposition, suggesting that tacstd is required for the deposition process. Developmental Dynamics 235:1578 -1588, 2006.

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Section: Loss-of-function Of Tacstdmentioning

confidence: 71%

Control of cell migration in the zebrafish lateral line: Implication of the gene “Tumour-Associated Calcium Signal Transducer,”tacstd

et al. 2006

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“…The trail of INC migrates ventrally, much as differentiated neuromasts do. As these cells move and become separated from the lateral-line nerve, local cell proliferation results in local thickenings of the trail (Grant et al 2005;Lopez-Schier and Hudspeth 2005). The resulting local clusters will eventually become intercalary neuromasts.…”

Section: Growth By Intercalation: Glial Control Of Sensory Developmentmentioning

confidence: 99%

The lateral line microcosmos

Ghysen¹,

2007

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The lateral-line system is a simple sensory system comprising a number of discrete sense organs, the neuromasts, distributed over the body of fish and amphibians in species-specific patterns. Its development involves fundamental biological processes such as long-range cell migration, planar cell polarity, regeneration, and postembryonic remodeling. These aspects have been extensively studied in amphibians by experimental embryologists, but it is only recently that the genetic bases of this development have been explored in zebrafish. This review discusses progress made over the past few years in this field.

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“…Interneuromast cells deposited by primI are normally kept quiescent for several days by the glial cells that accompany the afferent axons (Grant et al, 2005;Lopez-Schier and Hudspeth, 2005). Ganglion ablation prevents the migration of glial cells along afferent axons (Gilmour et al, 2002), therefore leading to precocious proliferation of interneuromast cells and to the formation of intercalary neuromasts.…”

Section: Neuromast Innervation By the Regenerated Ganglionmentioning

confidence: 99%

Origin and Early Development of the Posterior Lateral Line System of Zebrafish

Sarrazin¹,

Nuñez²,

Sapède³

et al. 2010

Journal of Neuroscience

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The lateral line system of teleosts has recently become a model system to study patterning and morphogenesis. However, its embryonic origins are still not well understood. In zebrafish, the posterior lateral line (PLL) system is formed in two waves, one that generates the embryonic line of seven to eight neuromasts and 20 afferent neurons and a second one that generates three additional lines during larval development. The embryonic line originates from a postotic placode that produces both a migrating sensory primordium and afferent neurons. Nothing is known about the origin and innervation of the larval lines. Here we show that a "secondary" placode can be detected at 24 h postfertilization (hpf), shortly after the primary placode has given rise to the embryonic primordium and ganglion. The secondary placode generates two additional sensory primordia, primD and primII, as well as afferent neurons. The primary and secondary placodes require retinoic acid signaling at the same stage of late gastrulation, suggesting that they share a common origin. Neither primary nor secondary neurons show intrinsic specificity for neuromasts derived from their own placode, but the sequence of neuromast deposition ensures that neuromasts are primarily innervated by neurons derived from the cognate placode. The delayed formation of secondary afferent neurons accounts for the capability of the fish to form a new PLL ganglion after ablation of the embryonic ganglion at 24 hpf.

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Supernumerary neuromasts in the posterior lateral line of zebrafish lacking peripheral glia

Cited by 90 publications

References 28 publications

Control of cell migration in the zebrafish lateral line: Implication of the gene “Tumour-Associated Calcium Signal Transducer,”tacstd

Control of cell migration in the zebrafish lateral line: Implication of the gene “Tumour-Associated Calcium Signal Transducer,”tacstd

The lateral line microcosmos

Origin and Early Development of the Posterior Lateral Line System of Zebrafish

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