2023
DOI: 10.1101/2023.10.30.563978
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Superovulation and aging perturb oocyte-granulosa cell communication

Klaudija Daugelaite,
Perrine Lacour,
Ivana Winkler
et al.

Abstract: In vitrofertilization has been developed to overcome reduced fertility, which is increasingly due to a decline in reproductive cell quality during aging. Here, we quantitatively investigated the interplay between superovulation and aging in mouse oocytes and their paired granulosa cells using newly adapted isolation techniques. We tested the hypothesis that superovulation disrupts oocyte maturation, revealing the key intercellular communication pathways dysregulated by forced hormonal stimulation. We further d… Show more

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