Superovulation with intrauterine insemination in the treatment of infertility: a possible alternative to gamete intrafallopian transfer and in vitro fertilization

Dodson, William C.; Whitesides, Daniel B.; Hughes, Claude L.; Easley, Henry A.; Haney, A.F.

doi:10.1016/s0015-0282(16)59414-x

Cited by 174 publications

(58 citation statements)

References 13 publications

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“…There is no consensus about the role of ovulation induction combined with IUI. Several reports show improved pregnancy rates in cases of hormonal treatment (Amy and Quagliarello, 1987;Dodson et al, 1987;Serhal et al, 1988;Martinez et al, 1990) but others do not support these data (Lalich et al, 1988;Corson et al, 1989). Most of these studies suffer from a small patient population and lack matched control groups and welldefined inclusion criteria.…”

Section: Discussionmentioning

confidence: 99%

Intrauterine insemination: evaluation of the results according to the woman's age, sperm quality, total sperm count per insemination and life table analysis

et al. 1996

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We report on 332 infertile couples who underwent 1115 cycles of intrauterine insemination (IUI) with washed husband's semen. The indication for IUI was an abnormal post-coital test due to either a male or cervical infertility factor. The mean number of IUI cycles per patient was 3.4, the overall pregnancy rate 18.7%, and the pregnancy rate per cycle 5.6%. The cumulative pregnancy rate calculated by life table analysis showed that 16.0% of pregnancies occurred in the first three treatment cycles, while the cumulative pregnancy rate was 26.9% by the sixth cycle. The outcome of the therapy was adversely affected if the woman's age was >39 years and/or total motile sperm count per insemination was <1X1O*. No pregnancy occurred in women older than 44 years or in cases with a total motile sperm count before semen preparation of <1X1O*.

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Section: Discussionmentioning

confidence: 99%

Intrauterine insemination: evaluation of the results according to the woman's age, sperm quality, total sperm count per insemination and life table analysis

et al. 1996

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“…The incidence has been reported to be as high as 30% of the infertile population. 44 Many therapeutic options have been reported and studied. There is some controversy about the potential advantages of IVF over simply observation for couples experiencing idiopathic infertility.…”

Section: Anovulationmentioning

confidence: 99%

Advances and Controversies in Assisted Reproductive Technology

Vela

Luna

Sandler

et al. 2009

Mount Sinai J Medicine

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As the incidence and awareness of infertility have increased in the last decades, reproductive endocrinologists and scientists have striven to improve the therapeutic options being offered to patients. One of the most advanced and efficient technologies currently being offered is assisted reproductive technology. Among the various techniques that are comprised by assisted reproductive technology, in vitro fertilization is the most widely studied and used, being responsible for approximately 1% of all live births in the United States. As this technology has evolved, many controversies have arisen, and it is the purpose of this article to review what in the authors' opinion are the most current and controversial aspects of the whole process of in vitro fertilization and its related techniques. Mt Sinai J Med 76:506‐520, 2009. © 2009 Mount Sinai School of Medicine

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“…It has been sug gested that superovulation also increases the probability of ovum pick-up by the oviduct, fertilization, ovum transport and successful nidation. Moreover, some ovulatory disor ders may be corrected by HMG therapy [8], The value of HMG superovulation com bined with IUI has been shown in cases of unexplained infertility. Pergonal treatment and IUI has yielded a significantly greater pregnancy rate per cycle than treatment with IUI or Pergonal alone: a pregnancy rate of 40.9% per couple and 26.4% per cycle has been reported, while the rate for IUI alone was 6.7% per patient and 2.7% per cycle [17].…”

Section: Discussionmentioning

confidence: 99%

“…Some workers have reported that the conception rate in men with oligoasthenospermia improved with the IUI of washed motile spermatozoa [6]. Others, however, observed a low pregnancy rate af ter IUI in cases of male infertility and advo cated IVF as a successful alternative [7], One retrospective study has concluded that IUI in cycles stimulated by human menopausal gonadotrophin (HMG), in cases of endome triosis and idiopathic infertility, yielded cy cle fecundity comparable to the success rates for couples treated with IVF and gamete intrafallopian transfer [8], The present con trolled prospective study was undertaken to evaluate the value of IUI coupled with superovulation in the treatment of couples affected by male infertility.…”

Section: Introductionmentioning

confidence: 99%

Intra-Uterine Insemination with Superovulation in the Treatment of Male Infertility

Ibrahim

Al-Tahir

Al-Mutawa

1990

Med Principles Pract

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The value of intra-uterine insemination (IUI) coupled with superovulation was studied in two groups of couples infertile because of male subfertility. IUI was carried out on 38 women during 78 treatment cycles after stimulation of ovulation with Clomid and human menopausal gonadotrophin (HMG) and on 29 women during 79 treatment cycles without stimulation. The pregnancy rate per patient (28.9%) and per treatment cycle (14.1%) was significantly higher in the stimulated group (p = 0.05 and p = 0.01, respectively). This could be attributed to a significantly higher number of follicles recruited (p < 0.001), since there was homogeneity between the two groups for other confounding factors. It is concluded that superovulation improves the pregnancy rate in couples with male subfertility treated with IUI.

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Superovulation with intrauterine insemination in the treatment of infertility: a possible alternative to gamete intrafallopian transfer and in vitro fertilization

Cited by 174 publications

References 13 publications

Intrauterine insemination: evaluation of the results according to the woman's age, sperm quality, total sperm count per insemination and life table analysis

Intrauterine insemination: evaluation of the results according to the woman's age, sperm quality, total sperm count per insemination and life table analysis

Advances and Controversies in Assisted Reproductive Technology

Intra-Uterine Insemination with Superovulation in the Treatment of Male Infertility

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