1994
DOI: 10.1073/pnas.91.3.1044
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Superoxide and peroxynitrite inatherosclerosis.

Abstract: The role of reactive oxygen species in the vascular pathology asiated with atherosclerosis was examined by testing the hypothesis that impaired vascular reactivity results from the reaction of nitric oxide (NO) with superoxide (O2), yielding the oxidant peroynitrite (ONOO-). Contractility studies were performed on femoral arteries from rabbits fed a cholesterol-supplemented diet Endothelium-dependent relaxation is impaired in vessels from atherosclerotic patients (1, 2) and hypercholesterolemic animal models (… Show more

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Cited by 658 publications
(389 citation statements)
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“…This makes CVD the leading cause of death for both men and women of all ethnicities (AHA 2004a). In addition, increases in ROS have been related to the onset of cardiovascular diseases, including hypertension, atherosclerosis, and diabetes mellitus (White et al 1994;Mugge 1998;Kojda et al 1999;Pepine et al 2001;Harrison et al 2003a). Our understanding of the early stages and mechanisms of cardiovascular disease is still developing.…”
Section: Epidemiological Datamentioning
confidence: 99%
“…This makes CVD the leading cause of death for both men and women of all ethnicities (AHA 2004a). In addition, increases in ROS have been related to the onset of cardiovascular diseases, including hypertension, atherosclerosis, and diabetes mellitus (White et al 1994;Mugge 1998;Kojda et al 1999;Pepine et al 2001;Harrison et al 2003a). Our understanding of the early stages and mechanisms of cardiovascular disease is still developing.…”
Section: Epidemiological Datamentioning
confidence: 99%
“…Increasing evidence now suggests that peroxynitrite is a major agent causing tissue damage induced by inflammation in vivo [9][10][11]. Peroxynitrite oxidizes sulfhydryl groups and induces membrane lipid peroxidation [12][13][14].…”
Section: Introductionmentioning
confidence: 99%
“…because it is about twice as fast as the maximum velocity of SOD. 1 Consequently, peroxynitrite has been implicated in many pathological conditions including stroke (3), heart disease (4), and atherosclerosis (5,6). The potential cellular targets for peroxynitrite cytotoxicity include the antioxidants ascorbate, ␣-tocopherol, and uric acid (7)(8)(9)(10), protein and non-protein sulfhydryls (11), DNA (12), and membrane phospholipids (13).…”
mentioning
confidence: 99%