Superoxide Anion-Induced Histamine Release from Rat Peritoneal Mast Cells.

Akagi, Masaaki; Katakuse, Yoshitaka; Fukuishi, Nobuyuki; Kan, Tomoko; Akagi, Reiko

doi:10.1248/bpb.17.732

Cited by 32 publications

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“…4,25) Accordingly, calcium-filling state in the endoplasmic reticulum blocks a calcium influx into RPMC, which leads to the reduction of the intracellular calcium content. 26) Consequently, decreased intracellular calcium prevents histamine release from RPMC.…”

Section: Discussionmentioning

confidence: 99%

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Inhibition of Anaphylaxis-Like Reaction and Mast Cell Activation by Water Extract from the Fruiting Body of Phellinus linteus

Choi

Yan

Chai

et al. 2006

Biological & Pharmaceutical Bulletin

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Mast cells are important mediators of immediate hypersensitivity, such as allergy and anaphylaxis. In response to the IgE-dependent and IgE-independent stimuli, mast cells elicit degranulation, which results in releasing various mediators, such as histamine and an array of inflammatory cytokines. Histamine, a main content of granules in mast cells, exerts many effects related to the acute phase of immediate hypersensitivity, including vasodilatation, increased vascular permeability, and tissue edema. 1) Mast cell degranulation can also be elicited by the basic secretagogues. The most potent secretagogues include the compound 48/80, which is a mixed polymer of phenethylamine cross-linked by formaldehyde. 2)In general, compound 48/80 initiates the generation of superoxide anion by A-kinase inactivation through decreasing the intracellular cAMP concentration in mast cells.3) Generated superoxide anion results in the increase of intracellular calcium content, which leads to histamine release from mast cells.4) Thus, compound 48/80 has been used as a direct and convenient reagent to study the mechanism of allergy and anaphylaxis. 1)Phellinus linteus, an orange color mushroom growing well on mulberry tree, is a well-known fungus of the genus Phellinus in the family of Hymenochaetaceae and has been used as a traditional herb medicine in oriental countries. 5)Proteoglycan isolated from Phellinus linteus has been shown to have anti-tumor and immunomodulatory effects.6) It has also been shown to alleviate the septic shock induced by the lipopolysaccharide injection in mice and to be involved in the prevention and treatment of autoimmune joint inflammation such as rheumatoid arthritis. 7,8) Moreover, ethanol extract of Phellinus linteus exhibits potent anti-oxidant and anti-angiogenic activities.9) Lim et al. have reported that organic solvent extracts of Phellinus linteus suppress IgE production by modulating helper T lymphocytes 1/2 balance in murine splenocytes and mesenteric lymph node lymphocytes. 10,11) Inagaki et al. have also demonstrated that a boiling water fraction from mycelium of Phellinus linteus inhibits IgE-dependent mouse triphasic cutaneous reaction.12) However, direct cellular mechanism underlying the mast cell-mediated anaphylaxis-like reaction has poorly been understood. In this study, we have investigated the inhibitory mechanism of water extract from the fruiting body of Phellinus linteus against the anaphylaxis-like reaction and mast cell activation. MATERIALS AND METHODS MaterialsCompound 48/80, disodium cromoglycate (DSCG), anti-DNP IgE, DNP-human serum albumin (HSA), bovine serum albumin (BSA) and HEPES were purchased from Sigma Chemical Co. (St. Louis, MO, U.S.A.). Percoll solution was purchased from Pharmacia (Uppsala, Sweden).Experimental Animals Male Balb/c (7 week old, 21-25 g), ICR (6 week old, 25-30 g) mice and Sprague-Dawley rats (8 week old, 230-280 g) were purchased from Damool Science (Daejeon, Korea). Animals were housed 3-5 per cages in laminar air-flow cabinet maintained at 22Ϯ1°C a...

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Section: Discussionmentioning

confidence: 99%

“…4) Thus, compound 48/80 has been used as a direct and convenient reagent to study the mechanism of allergy and anaphylaxis. 1) Phellinus linteus, an orange color mushroom growing well on mulberry tree, is a well-known fungus of the genus Phellinus in the family of Hymenochaetaceae and has been used as a traditional herb medicine in oriental countries.…”

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confidence: 99%

Inhibition of Anaphylaxis-Like Reaction and Mast Cell Activation by Water Extract from the Fruiting Body of Phellinus linteus

Choi

Yan

Chai

et al. 2006

Biological & Pharmaceutical Bulletin

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“…For example, chemically derived superoxide, generated from xanthine-xanthine oxidase (15,44,45) or potassium superoxide (46), and hydrogen peroxide (47) have been shown to induce rat peritoneal mast cell degranulation. Furthermore, FMLP-(48) or zymosan-activated (49) human neutrophils at high cell density (10 6 /ml) caused mast cell histamine release, and the oxidant responsible was identified as hydrogen peroxide.…”

Section: Discussionmentioning

confidence: 99%

A Comparison of Reactive Oxygen Species Generation by Rat Peritoneal Macrophages and Mast Cells Using the Highly Sensitive Real-Time Chemiluminescent Probe Pholasin: Inhibition of Antigen-Induced Mast Cell Degranulation by Macrophage-Derived Hydrogen Peroxide

Swindle

Hunt

Coleman

2002

The Journal of Immunology

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Mast cells and macrophages live in close proximity in vivo and reciprocally regulate one another’s function in various ways. Although activated macrophages possess a powerful reactive oxygen species (ROS) generating system, there is conflicting evidence regarding whether mast cells can produce ROS. We used the highly sensitive real-time chemiluminescent probe Pholasin to examine ROS release by peritoneal macrophages and mast cells isolated from OVA-sensitized rats. Macrophages stimulated with PMA (0.8 μM) or ionomycin (1 μM), but not OVA (1 μg/ml), released high-level ROS, levels of which peaked after 3–7 min and declined to baseline levels within 1 h. Superoxide was identified as the major ROS species induced by PMA but not by ionomycin. In contrast, purified mast cells stimulated with PMA released low-level ROS, which was entirely due to the contaminating (2%) macrophages, and did not release any detectable ROS in response to ionomycin or OVA at concentrations that induced degranulation. Stimulation of mixed cell populations with PMA to induce macrophage ROS release led to 50% inhibition of serotonin release from mast cells stimulated 5 min later with OVA. The PMA-induced inhibitory factor was identified as hydrogen peroxide. In conclusion, activated rat peritoneal macrophages but not mast cells produce ROS, and macrophage-derived hydrogen peroxide inhibits mast cell degranulation. The latter could be an important mechanism whereby phagocytic cells regulate mast cell activation and promote resolution of IgE-mediated inflammation.

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“…The effects of resveratrol, pterostilbene, piceatannol, and their glycosides on compound 48/80-induced histamine release from rat peritoneal mast cells were examined as follows. [21][22][23] Peritoneal mast cells were collected from the abdominal cavities of rats (Male Wistar rats, Nippon SLC) and purified to a level higher than 95% according to the method described previously. [21][22][23] The purified mast cells were suspended in a physiological buffered solution (PBS) containing 145 mM NaCl, 2.7 mM KCl, 1.0 mM CaCl 2 , 5.6 mM glucose, and 20 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) (pH 7.4) to give approximately 10 4 mast cells/mL.…”

Section: Analysesmentioning

confidence: 99%

“…Mast cells were preincubated with the test compound (1 μM) for 15 min at 37°C, and subsequently exposed to compound 48/80 at 0.35 μg/mL. Histamine release was determined by a fluorometric assay as described previously, [21][22][23] and was expressed as a percentage of total histamine.…”

Section: Analysesmentioning

confidence: 99%

Synthesis of glycosides of resveratrol, pterostilbene, and piceatannol, and their anti-oxidant, anti-allergic, and neuroprotective activities

Sato

Shimizu

et al. 2014

Bioscience, Biotechnology, and Biochemistry

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Resveratrol was glucosylated to its 3- and 4′-β-glucosides by cultured cells of Phytolacca americana. On the other hand, cultured P. americana cells glucosylated pterostilbene to its 4′-β-glucoside. P. americana cells converted piceatannol into its 4′-β-glucoside. The 3- and 4′-β-glucosides of resveratrol were further glucosylated to 3- and 4′-β-maltosides of resveratrol, 4′-β-maltoside of which is a new compound, by cyclodextrin glucanotransferase. Resveratrol 3-β-glucoside and 3-β-maltoside showed low 2,2-diphenyl-1-picrylhydrazyl free-radical-scavenging activity, whereas other glucosides had no radical-scavenging activity. Piceatannol 4′-β-glucoside showed the strongest inhibitory activity among the stilbene glycosides towards histamine release from rat peritoneal mast cells. Pterostilbene 4′-β-glucoside showed high phosphodiesterase inhibitory activity.

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Superoxide Anion-Induced Histamine Release from Rat Peritoneal Mast Cells.

Cited by 32 publications

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Inhibition of Anaphylaxis-Like Reaction and Mast Cell Activation by Water Extract from the Fruiting Body of Phellinus linteus

Inhibition of Anaphylaxis-Like Reaction and Mast Cell Activation by Water Extract from the Fruiting Body of Phellinus linteus

A Comparison of Reactive Oxygen Species Generation by Rat Peritoneal Macrophages and Mast Cells Using the Highly Sensitive Real-Time Chemiluminescent Probe Pholasin: Inhibition of Antigen-Induced Mast Cell Degranulation by Macrophage-Derived Hydrogen Peroxide

Synthesis of glycosides of resveratrol, pterostilbene, and piceatannol, and their anti-oxidant, anti-allergic, and neuroprotective activities

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