Superoxide dismutase and catalase activity in naturally derived commercial surfactants

Dani, Carlo; Buonocore, Giuseppe; Longini, Mariangela; Felici, Cristina; Rodriguez, Antonello; Corsini, Iuri; Rubaltelli, Firmino F.

doi:10.1002/ppul.21116

Cited by 26 publications

(30 citation statements)

References 28 publications

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“…Decreased oxygen support after surfactant may have alleviated the deleterious effects of oxygen on the oxidant/antioxidant balance. Dani et al 26 have demonstrated that commercial natural surfactants showed measurable SOD and catalase activities, which differed between surfactants, likely due to their different origins and preparation procedures. All studied surfactants exhibited scavenger activity against H 2 O 2 with poractant, which was used in this study, and beractant having the highest antioxidant effect.…”

Section: Rdsmentioning

confidence: 99%

“…The surfactant proteins protect unsaturated phospholipids and growing cells from oxidative injury at physiological concentrations. 25 Dani et al 26 demonstrated superoxide dismutase (SOD) and catalase activities in four natural surfactants, as well as scavenger activity against hydrogen peroxide. However, data on the in vivo effect of surfactant on oxidant -antioxidant balance and association with clinical outcomes is limited.…”

Section: Introductionmentioning

confidence: 99%

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Total antioxidant capacity and total oxidant status after surfactant treatment in preterm infants with respiratory distress syndrome

et al. 2011

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Background: Oxidative damage is important in the pathogenesis of respiratory distress syndrome (RDS). However, data on the effect of surfactant therapy on oxidative stress in vivo are limited. We aimed to evaluate the oxidant/antioxidant status in preterm infants with RDS via measurement of total antioxidant capacity (TAC) and total oxidant status (TOS), to determine the effect of surfactant on oxidant/antioxidant balance and to assess the association between TAC, TOS and clinical outcomes of the patients. Methods: Sixty-nine infants with RDS were included. Blood samples for determining TAC and TOS were collected before and 48 h after surfactant treatment. TAC and TOS levels were analysed in serum. Patients were followed up until discharge or death. Results: Post-surfactant TAC levels were significantly higher than pre-surfactant TAC levels (P ¼ 0.029). TAC/TOS ratio significantly increased after surfactant treatment (P ¼ 0.018). Infants ,28 weeks of gestational age had lower levels of baseline TAC than those 28 weeks of gestational age (P ¼ 0.020), whereas TOS levels were similar. Baseline TAC/TOS ratio was lower in infants who died in the study period than those who survived (P ¼ 0.023). After controlling gestational age, baseline TAC levels were significantly and inversely correlated with the duration of total respiratory support (r ¼ 20.343; P ¼ 0.009) and hospitalization (r ¼ 20.341; P ¼ 0.009). TAC or TOS levels were not associated with the development of bronchopulmonary dysplasia or other complications as determined during the investigation period. Conclusions: Oxidant-antioxidant balance shifts in favour of the antioxidant system after surfactant treatment. Lower TAC/ TOS ratio in preterm infants may be associated with increased mortality.

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Section: Rdsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Total antioxidant capacity and total oxidant status after surfactant treatment in preterm infants with respiratory distress syndrome

et al. 2011

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“…On the contrary, a surfactant extract containing 1% proteins was shown to contain no significant amount of AOEs and did not exert any scavenging activity (97), strengthening the concept that protein compounds are of crucial importance to surfactant activities, which should be strongly considered in the setting of synthetic surfactant development. A recent study confirmed that four natural surfactants contain definite amounts of SOD and CAT, which have been detailed for Poractant, Beractant, Calfactant, and Bovactant (31). Poractant provided the highest content of SOD per ml, while Calfactant was proved to contain the highest amount of CAT.…”

Section: Surfactant Administration In Rds: Potential Antioxidant Contmentioning

confidence: 63%

“…Moreover, Poractant provided the major amount of SOD per recommended dose for clinical use, while Calfactant was proved to contain the major amount of CAT per dose. Poractant also showed the highest scavenger activity when incubated with H 2 O 2 (31). Despite relevant results obtained in vitro, the role of surfactant AOEs in vivo remains to be established.…”

Section: Surfactant Administration In Rds: Potential Antioxidant Contmentioning

confidence: 97%

“…Besides the well-known beneficial effects on alveolar surface tension and mechanics (123,124), the surfactant was also proved to possess anti-inflammatory and antioxidant properties (31,96,97), possibly contributing to the benefits of surfactant administration in RDS. The exogenous surfactant not only replaces the pre-existing surfactant partially inactivated by ROS (97), but also naturally contains specific proteins and minor lipids with antioxidant activities (Table 5).…”

Section: Surfactant Administration In Rds: Potential Antioxidant Contmentioning

confidence: 99%

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The Role of Genetic Polymorphisms in Antioxidant Enzymes and Potential Antioxidant Therapies in Neonatal Lung Disease

Dani

Poggi

2014

Antioxidants & Redox Signaling

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Significance: Oxidative stress is involved in the development of newborn lung diseases, such as bronchopulmonary dysplasia and persistent pulmonary hypertension of the newborn. The activity of antioxidant enzymes (AOEs), which is impaired as a result of prematurity and oxidative injury, may be further affected by specific genetic polymorphisms or an unfavorable combination of more of them. Recent Advances: Genetic polymorphisms of superoxide dismutase and catalase were recently demonstrated to be protective or risk factors for the main complications of prematurity. A lot of research focused on the potential of different antioxidant strategies in the prevention and treatment of lung diseases of the newborn, providing promising results in experimental models. Critical Issues: The effect of different genetic polymorphisms on protein synthesis and activity has been poorly detailed in the newborn, hindering to derive conclusive results from the observed associations with adverse outcomes. Therapeutic strategies that aimed at enhancing the activity of AOEs were poorly studied in clinical settings and partially failed to produce clinical benefits. Future Directions: The clarification of the effects of genetic polymorphisms on the proteomics of the newborn is mandatory, as well as the assessment of a larger number of polymorphisms with a possible correlation with adverse outcome. Moreover, antioxidant treatments should be carefully translated to clinical settings, after further details on optimal doses, administration techniques, and adverse effects are provided. Finally, the study of genetic polymorphisms could help select a specific high-risk population, who may particularly benefit from targeted antioxidant strategies.

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Extrapulmonary Surfactant Therapy: Review of Available Data and Research/Development Issues

Foligno

Loi

Pezza

et al. 2020

The Journal of Clinical Pharma

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Since the discovery of surfactant, a large amount of knowledge has been accumulated about its biology and pharmacology. Surfactant is the cornerstone of neonatal respiratory critical care, but its proteins and phospholipids are produced in various tissues and organs, with possible roles only partially similar to that played in the alveoli. As surfactant research is focused mainly on its respiratory applications, knowledge about the possible role of surfactant in extrapulmonary disorders has never been summarized. Here we aim to comprehensively review the data about surfactant biology and pharmacology in organs other than the lung, especially focusing in the more promising surfactant extrapulmonary roles. We also review any preclinical or clinical data available about the therapeutic use of surfactant in these contexts. We offer a summary of knowledge and research/development milestones, as possible useful guidance for researchers of multidisciplinary background.

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Superoxide dismutase and catalase activity in naturally derived commercial surfactants

Cited by 26 publications

References 28 publications

Total antioxidant capacity and total oxidant status after surfactant treatment in preterm infants with respiratory distress syndrome

Total antioxidant capacity and total oxidant status after surfactant treatment in preterm infants with respiratory distress syndrome

The Role of Genetic Polymorphisms in Antioxidant Enzymes and Potential Antioxidant Therapies in Neonatal Lung Disease

Extrapulmonary Surfactant Therapy: Review of Available Data and Research/Development Issues

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