Superoxide dismutase as multipotent therapeutic antioxidant enzyme: Role in human diseases

Saxena, Priyanka; Selvaraj, Kanagarethinam; Khare, Sunil Kumar; Chaudhary, Nidhee

doi:10.1007/s10529-021-03200-3

Cited by 61 publications

(27 citation statements)

References 62 publications

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“…SOD can be naturally found in vegetables, such as broccoli and cabbage, and it has been noted that a controlled supplementation with SOD can protect the immune system, potentially reducing the incidence of diseases [ 77 ]. Thus, tackling SOD has been proven a useful tool against various diseases [ 78 , 79 ], including AD [ 80 ], PD [ 81 ], and ALS [ 82 , 83 ].…”

Section: Neuroprotection and Antioxidantsmentioning

confidence: 99%

An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases

Teleanu

Niculescu

Lungu

et al. 2022

IJMS

383

139

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Oxidative stress has been linked with a variety of diseases, being involved in the debut and/or progress of several neurodegenerative disorders. This review intends to summarize some of the findings that correlate the overproduction of reactive oxygen species with the pathophysiology of Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. Oxidative stress was also noted to modify the inflammatory response. Even though oxidative stress and neuroinflammation are two totally different pathological events, they are linked and affect one another. Nonetheless, there are still several mechanisms that need to be understood regarding the onset and the progress of neurodegenerative diseases in order to develop efficient therapies. As antioxidants are a means to alter oxidative stress and slow down the symptoms of these neurodegenerative diseases, the most common antioxidants, enzymatic as well as non-enzymatic, have been mentioned in this paper as therapeutic options for the discussed disorders.

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Section: Neuroprotection and Antioxidantsmentioning

confidence: 99%

An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases

Teleanu

Niculescu

Lungu

et al. 2022

IJMS

383

139

View full text Add to dashboard Cite

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“…Byproducts as dangerous and toxic ROS are typically generated by common metabolism processes that are considered critical for the survival and protection of living organisms (Lakra et al 2022;Saxena et al 2022). Free radicals usually lead to oxidative stress and other health issues.…”

Section: Antioxidant Studymentioning

confidence: 99%

Biogenic synthesis of reduced graphene oxide from Ziziphus spina-christi (Christ’s thorn jujube) extracts for catalytic, antimicrobial, and antioxidant potentialities

Mahmoud

El-Maghrabi

Hosny

et al. 2022

Environ Sci Pollut Res

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In the current work, various concentrations of the aqueous extract of Ziziphus spina-christi were employed for the phytoreduction of graphene oxide (GO). The green synthesized reduced graphene oxide (rGO) was characterized through UV-Vis spectrometry, Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy, and energy-dispersive X-ray spectroscopy (SEM-EDX). Gas chromatography-mass spectrometry (GC-MS) denoted the presence of numerous phytoconstituents including ketones, terpenoids, fatty acids, esters, and flavonoids, which acted as reducing and capping agents. The obtained results indicated the increase in rGO yield and shape with increasing the extract concentration. The optimized rGO was instantaneously ~100% removed methylene blue (MB) from the water at 5 mg L−1. However, the removal efficiency was slightly declined to reach 73.55 and 65.1% at 10 and 15 mg L−1, respectively. A powerful antibacterial activity for rGO particularly against gram-negative bacteria with a high concentration of 2 × 108 CFU mL−1 was confirmed. Furthermore, rGO demonstrated promising and comparable antioxidant efficiency with vitamin C against DPPH free radical scavenging. While vitamin C recorded 13.45 and 48.4%, the optimized rGO attained 13.30 and 45.20% at 12 and 50 μg mL−1, respectively.

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“…Common enzymes that can remove ROS include SOD and so on (Saxena et al, 2022). Some short peptides, such as GSH, are also involved in the removal of intracellular ROS( (Yang et al, 2016)).…”

Section: Nanomaterials Loaded With Ros Scavengermentioning

confidence: 99%

Application and prospect of ROS-related nanomaterials for orthopaedic related diseases treatment

et al. 2022

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The importance of reactive oxygen species (ROS) in the occurrence and development of orthopaedic related diseases is becoming increasingly prominent. ROS regulation has become a new method to treat orthopaedic related diseases. In recent years, the application of nanomaterials has become a new hope for precision and efficient treatment. However, there is a lack of reviews on ROS-regulated nanomaterials for orthopaedic related diseases. Based on the key significance of nanomaterials for the treatment of orthopaedic related diseases, we searched the latest related studies and reviewed the nanomaterials that regulate ROS in the treatment of orthopaedic related diseases. According to the function of nanomaterials, we describe the scavenging of ROS related nanomaterials and the generation of ROS related nanomaterials. In this review, we closely integrated nanomaterials with the treatment of orthopaedic related diseases such as arthritis, osteoporosis, wound infection and osteosarcoma, etc., and highlighted the advantages and disadvantages of existing nanomaterials. We also looked forward to the design of ROS-regulated nanomaterials for the treatment of orthopaedic related diseases in the future.

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Superoxide dismutase as multipotent therapeutic antioxidant enzyme: Role in human diseases

Cited by 61 publications

References 62 publications

An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases

An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases

Biogenic synthesis of reduced graphene oxide from Ziziphus spina-christi (Christ’s thorn jujube) extracts for catalytic, antimicrobial, and antioxidant potentialities

Application and prospect of ROS-related nanomaterials for orthopaedic related diseases treatment

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