Superoxide dismutase (SOD) for mustard gas burns

Eldad, Arieh; Meir, Patrik Ben; Breiterman, Semion; Chaouat, Malka; Shafran, Aaron; Ben‐Bassat, Hannah

doi:10.1016/s0305-4179(97)00085-5

Cited by 28 publications

(16 citation statements)

References 8 publications

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“…4 For instance, SOD can be used in treating mustard gas burns. 48 Furthermore, the positive effects of SOD on the recovery of human hematopoietic stem cells have been successfully shown. 49 In addition, up-regulation of SOD expression inhibits breast cancer growth.…”

Section: Discussionmentioning

confidence: 99%

Time- and dose-dependent differential regulation of copper-zinc superoxide dismutase and manganese superoxide dismutase enzymatic activity and mRNA level by vitamin E in rat blood cells

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Time- and dose-dependent differential regulation of copper-zinc superoxide dismutase and manganese superoxide dismutase enzymatic activity and mRNA level by vitamin E in rat blood cells

et al. 2012

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“…Superoxide dismutase (SOD) reduced lung injury by 23%, but these changes were not significant. Eldad et al, 39 using a guinea pig model of HD-induced skin burns, saw significant reductions in the skin lesions when SOD was given intraperitoneally or intralesionally 1 or 3 h in advance of wound infliction. No protection was seen when SOD was given 1 h after skin exposure.…”

Section: Discussionmentioning

confidence: 99%

“…Mustard agents can be described more accurately as vesicating and tissue-damaging agents because of the severe widespread damage to the lungs, 7,8 internal organs 9 -12 and eyes, 13 as well as to the skin. 14,15 Mustard gas also has been described as radiomimetic, carcinogenic, teratogenic and mutagenic. 16 -19 It has been used recently in chemical attacks against the Iranians during the Gulf War of [1984][1985] and by the Iraqis in 1988 against their own Kurdish population.…”

Section: Introductionmentioning

confidence: 99%

Protection from half‐mustard‐gas‐induced acute lung injury in the rat

McClintock¹,

Till²,

Smith³

et al. 2002

J of Applied Toxicology

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The chemical warfare agent analog, 2-chloroethyl ethyl sulfide, known as 'half-mustard gas' (HMG), is less toxic and less of an environmental hazard than the full molecule and has been shown to produce an acute lung injury in rats when instilled via intrapulmonary injection. This injury is characterized by massive, localized hemorrhage and edema into the alveolar compartment and can be quantitated by measuring extravasation of (125)I-bovine serum albumin into the extravascular compartment. Employing this rat model of HMG-induced lung injury, we observed significant attenuation of the pulmonary injury when experimental animals were complement or neutrophil depleted prior to HMG challenge. Significant protection also was provided by the use of antioxidants such as catalase, dimethyl sulfoxide, dimethyl thiourea, resveratrol and N-acetyl-L-cysteine (NAC). The last compound showed protection from lung injury as high as 70% and was still effective even when given up to 90 min after exposure of the lungs to HMG. These data suggest that acute lung injury caused by exposure to HMG may be related partially to complement mediated pathways and the generation by neutrophils of toxic oxygen species The data indicate that NAC is an effective antidote against HMG-induced acute lung injury in the rat.

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“…The formula exhibits anti-inflammatory action (in in vitro and in vivo models), anti-oxidative action and anti-bacterial action . To test the Balsam's effectiveness on wound healing we used a surgical wound healing model on healthy rats and on diabetic rats, representing healing by first intention (Seror et al, 2003) and a thermal wound healing model on guinea pigs, representing healing by second intention (Eldad et al, 1998). We found no significant effect on wound healing, despite the Balsam's wide use for this purpose.…”

Section: Pharmacological Resultsmentioning

confidence: 76%

“…As a model for wound healing that involves the contraction of a wound (healing by second intention) we used a burn model (Eldad et al, 1998).…”

Section: Wound-healing Experimentsmentioning

confidence: 99%

The Jerusalem Balsam: From the Franciscan Monastery in the old city of Jerusalem to Martindale 33

Moussaieff

Fride

Amar

et al. 2005

Journal of Ethnopharmacology

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Superoxide dismutase (SOD) for mustard gas burns

Cited by 28 publications

References 8 publications

Time- and dose-dependent differential regulation of copper-zinc superoxide dismutase and manganese superoxide dismutase enzymatic activity and mRNA level by vitamin E in rat blood cells

Time- and dose-dependent differential regulation of copper-zinc superoxide dismutase and manganese superoxide dismutase enzymatic activity and mRNA level by vitamin E in rat blood cells

Protection from half‐mustard‐gas‐induced acute lung injury in the rat

The Jerusalem Balsam: From the Franciscan Monastery in the old city of Jerusalem to Martindale 33

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