Superoxide Dismutases in Biology and Medicine: Essentials and Recent Advances

Little, Ben D.; Hopkins, Robert Z.

doi:10.20455/ros.2020.803

Cited by 1 publication

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“…It is noteworthy that, during a healthy pregnancy, there is an increase in mitochondrial activity, particularly via the placenta (complex and membranous vascular organ, specific in the gestational period, capable of promoting the metabolic interaction between mother and fetus, through the transport of nutrients and oxygen, elimination of fetal metabolites, and hormonal production), which can lead to greater formation of ROS, greater generation of O 2 •− from NADPH oxidase, and alteration in the organic capacity to remove such compounds [ 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 ].…”

Section: Nitroxidative Stress In Gdmmentioning

confidence: 99%

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Gestational Diabetes Mellitus: The Crosslink among Inflammation, Nitroxidative Stress, Intestinal Microbiota and Alternative Therapies

et al. 2022

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Gestational diabetes mellitus (GDM) is characterized by a set of metabolic complications arising from adaptive failures to the pregnancy period. Estimates point to a prevalence of 3 to 15% of pregnancies. Its etiology includes intrinsic and extrinsic aspects of the progenitress, which may contribute to the pathophysiogenesis of GDM. Recently, researchers have identified that inflammation, oxidative stress, and the gut microbiota participate in the development of the disease, with potentially harmful effects on the health of the maternal-fetal binomial, in the short and long terms. In this context, alternative therapies were investigated from two perspectives: the modulation of the intestinal microbiota, with probiotics and prebiotics, and the use of natural products with antioxidant and anti-inflammatory properties, which may mitigate the endogenous processes of the GDM, favoring the health of the mother and her offspring, and in a future perspective, alleviating this critical public health problem.

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