Superoxide dismutases in retinal degeneration of WBN/Kob rat

Abstract

The retinal degeneration of WBN/Kob rats begins in the outer retina. The lack of SODs in the outer retina may contribute to retinal degeneration in the WBN/Kob rats.

An Electrophysiological Study of Retinal Function in the Diabetic Female Rat

“…Although ERG responses in female diabetic animals have been reported, 58 the animals that were studied possessed other severe ocular abnormalities or were shown subsequently to develop spontaneous retinal degeneration. 59,60 It would be difficult to ascribe the changes in retinal function to any specific diabetes-induced abnormality in the presence of such advanced ocular disease. Nevertheless, the results of the present study show that in many respects, the STZ-induced hyperglycemic response of female Long-Evans (pigmented) rats differs from that of male rats described in earlier studies.…”

Proteomic analysis of rat retina in a steroid-induced ocular hypertension model: Potential vulnerability to oxidative stress

“…40,41 SOD1 is present in the ganglion cell layer, inner plexiform layer, inner nuclear layer, outer nuclear layer, and photoreceptor inner segment. 42 However, it remains to be determined in which layer/cell types alterations of these proteins take place.…”

Glutathione Peroxidase Induced in Rat Retinas to Counteract Photic Injury

“…Although previous immunohistologic reports have shown that SOD, [15][16][17] catalase, 18 and GPX 19 -21 are found in similar sites in the normal rat retina, we previously reported changes in immunoreactivity of SOD with retinal degeneration, 22 aging, 23 developing, 24 and exposure to light. 11 Antioxidant protein mRNAs, including hemeoxygenase-1, metallothionein, CuZn SOD, and catalase, have been reported to have very different expression patterns in the developing rat retina.…”