Superoxide-imbalance Pharmacologically Induced by Rotenone Triggers Behavioral, Neural, and Inflammatory Alterations in the Eisenia fetida Earthworm

Mastella, Moisés Henrique; Roggia, Isabel; Turra, Bárbara Osmarin; Teixeira, Cibele Ferreira; Assmann, Charles Elias; Morais‐Pinto, Luciano de; Vidal, Taís; Melazzo, Cinthia; Jung, Ivo Emilio da Cruz; Barbisan, Fernanda; Cruz, Ivana Beatrice Mânica da

doi:10.1016/j.neuroscience.2022.07.035

Cited by 6 publications

(4 citation statements)

References 49 publications

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“…Lithium exhibits its effects through rodent models [12], in vitro cellular models [23,24], and in vivo substitution models such as Eisenia fetida [25]. Individuals with different genotypes may respond differently to lithium treatment [12,26].…”

Section: Ivyspring International Publishermentioning

confidence: 99%

“…Altered excitatory/inhibitory synaptic transmission is also found in ischemic stroke [170]. Multiple in vitro and in vivo experiments have demonstrated that lithium can play a role in ischemic stroke models [25]. Lithium may benefit in improving clinical outcomes for stroke patients [25].…”

Section: Group III Mglursmentioning

confidence: 99%

“…Multiple in vitro and in vivo experiments have demonstrated that lithium can play a role in ischemic stroke models [25]. Lithium may benefit in improving clinical outcomes for stroke patients [25]. Therefore, it is worthwhile to investigate whether lithium can exert a neuroprotective role in ischemic stroke models through mGluR5-mediated effects.…”

Section: Group III Mglursmentioning

confidence: 99%

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Exploring the Neuroprotective Effects of Lithium in Ischemic Stroke: A literature review

Wang,

Lu,

Shi

et al. 2024

Int. J. Med. Sci.

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Ischemic stroke ranks among the foremost clinical causes of mortality and disability, instigating neuronal degeneration, fatalities, and various sequelae. While standard treatments, such as intravenous thrombolysis and endovascular thrombectomy, prove effective, they come with limitations. Hence, there is a compelling need to develop neuroprotective agents capable of improving the functional outcomes of the nervous system. Numerous preclinical studies have demonstrated that lithium can act in multiple molecular pathways, including glycogen synthase kinase 3(GSK-3), the Wnt signaling pathway, the mitogen-activated protein kinase (MAPK)/ extracellular signal-regulated kinase (ERK) signaling pathway, brain-derived neurotrophic factor (BDNF), mammalian target of rapamycin (mTOR), and glutamate receptors. Through these pathways, lithium has been shown to affect inflammation, autophagy, apoptosis, ferroptosis, excitotoxicity, and other pathological processes, thereby improving central nervous system (CNS) damage caused by ischemic stroke. Despite these promising preclinical findings, the number of clinical trials exploring lithium's efficacy remains limited. Additional trials are imperative to thoroughly ascertain the effectiveness and safety of lithium in clinical settings. This review delineates the mechanisms underpinning lithium's neuroprotective capabilities in the context of ischemic stroke. It elucidates the intricate interplay between these mechanisms and sheds light on the involvement of mitochondrial dysfunction and inflammatory markers in the pathophysiology of ischemic stroke. Furthermore, the review offers directions for future research, thereby advancing the understanding of the potential therapeutic utility of lithium and establishing a theoretical foundation for its clinical application.

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Section: Ivyspring International Publishermentioning

confidence: 99%

Section: Group III Mglursmentioning

confidence: 99%

Section: Group III Mglursmentioning

confidence: 99%

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Exploring the Neuroprotective Effects of Lithium in Ischemic Stroke: A literature review

Wang,

Lu,

Shi

et al. 2024

Int. J. Med. Sci.

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show abstract

“…Nervous behavior is an integrated neural activity, which can comprehensively re ect the nerve injury of animals, and is an important indicator for evaluating the neurotoxicity of chemicals (Winneke et al, 2007;Gargouri et al, 2018;Wang et al, 2019;Mastella et al, 2022). Studies have shown that cypermethrin has an impact on the normal function of the animal nervous system and causes neurobehavioral disorders in animals (Casco et al, 2006;Tian et al, 2009;Singh et al, 2012;Liu et al, 2019;Zhou et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Subchronic Neurotoxic Effects of Cypermethrin on Earthworms

Zhao,

Wu,

Zhou

et al. 2024

Preprint

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Cypermethrin is one of the most heavily used pyrethroid pesticides worldwide and is a potential threat to soil organisms such as earthworms. In this paper, Amynthas corticis was selected as a test organism to investigate the neurobehavioral changes in movement, cognition and memory caused by subchronic neurotoxicity of cypermethrin in earthworms, starting from the changes in the characteristic enzymes of earthworms' nerve ion channels triggered by exposure to cypermethrin. The changes in biomarkers of earthworms were evaluated using the integrated biomarker response (IBR), and the mechanism of cypermethrin neurotoxicity in earthworms was investigated using molecular docking technology, so as to investigate the subchronic neurotoxicity of earthworms caused by exposure to cypermethrin. The results showed that the subchronic neurotoxicity of cypermethrin for earthworms increased with the increase of the exposure concentration and the duration of cypermethrin exposure. The chronic neurotoxicity of cypermethrin did not lead to earthworm death but induced neurobehavioral changes such as locomotor retardation and cognitive deficits in earthworms. Cypermethrin exposure induced abnormalities in the enzyme that characterizes nerve ion channels in earthworms, which is one of the possible molecular mechanisms for the neurobehavioral changes of locomotor retardation and cognition and memory disorders in earthworms.

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The Protective Effect of Lithium Against Rotenone may be Evolutionarily Conserved: Evidence from Eisenia fetida, a Primitive Animal with a Ganglionic Brain

Mastella,

Roggia,

Turra

et al. 2023

Neurochem Res

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Superoxide-imbalance Pharmacologically Induced by Rotenone Triggers Behavioral, Neural, and Inflammatory Alterations in the Eisenia fetida Earthworm

Cited by 6 publications

References 49 publications

Exploring the Neuroprotective Effects of Lithium in Ischemic Stroke: A literature review

Exploring the Neuroprotective Effects of Lithium in Ischemic Stroke: A literature review

Subchronic Neurotoxic Effects of Cypermethrin on Earthworms

The Protective Effect of Lithium Against Rotenone may be Evolutionarily Conserved: Evidence from Eisenia fetida, a Primitive Animal with a Ganglionic Brain

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