Superoxide Ion: Generation and Chemical Implications

Hayyan, Maan; Hashim, Mohd Ali; AlNashef, Inas M.

doi:10.1021/acs.chemrev.5b00407

Cited by 1,714 publications

(1,167 citation statements)

References 660 publications

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“…This has fortified the above fact that vitreous GTR could serve as veritable tool in detection of acute CO poisoning. Superoxide is produced as a by-product of oxygen metabolism and, if not regulated, causes many types of cell damage [34].…”

Section: Discussionmentioning

confidence: 99%

Vitreous Humour Lipid Peroxidation as an Emerging Concept of Acute Carbon Monoxide Poisoning

Es¹,

VN²

2017

IJFP

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Section: Discussionmentioning

confidence: 99%

Vitreous Humour Lipid Peroxidation as an Emerging Concept of Acute Carbon Monoxide Poisoning

Es¹,

VN²

2017

IJFP

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“…OH) is produced following reaction of hydrogen peroxide with metal ions such as Fe 2+ and Cu + (Hayyan et al, 2016). Sometimes it could be produced as a by-product of the immune activity.…”

Section: Hydroxyl Radical ( Oh)mentioning

confidence: 99%

The role of oxidative stress and inflammatory response in the pathogenesis of mastitis in dairy cows

Turk

2017

Mljekarstvo

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Mastitis is one of the most frequent diseases of dairy cows throughout the world, therefore it causes the greatest economic losses in dairy cattle industry. These losses are reflected through: reduced milk production, increased costs of medication and the other animal health services, reduced fertility, early culling of animals and the value of discarded milk. Mastitis is also important from the aspects of public health, milk processing and animal welfare. In the pathogenesis of mastitis the key role plays the innate immune response which is the first line of defence against the pathogen invasion of the udder. The innate immune response generates an inflammatory reaction which is the elementary response of an organism to the tissue trauma induced by any physical, chemical or biological causative agent, but primarily it is the protective mechanism of a vital significance which includes increased phagocytic activity, secretion of antimicrobial substances, fibrosis as well as the alterations in tissue structure of affected organ or body cavity. The release of a number of inflammatory mediators as well as reactive oxygen species (ROS) is an important part of inflammatory response. In dairy cows, the metabolic challenge that occurred during the transition from dry period to early lactation may additionally increase the release of ROS which may contribute to development of oxidative stress and inflammatory response. Oxidative stress is defined as a shift in the balance from cellular oxidation-reduction reactions towards oxidation, i.e. to the state of excessive release of oxidants when their removal by antioxidants is impaired and even insufficient. During peripartum period antioxidantive status of dairy cows is seriously impaired and consequently both the oxidative stress and inflammatory response may present the predisposing factors to their higher susceptibility to intramammary infections (IMI) and mastitis. This association between oxidative stress and inflammation during IMI and mastitis indicates their role in the pathogenesis of mastitis. Thus, a better understanding of such a synergism could contribute to development of new approaches to prevention and therapy of IMI and mastitis.

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“…Hydroxyl radical, singlet oxygen and superoxide peroxides are a chemically reactive chemical species which contains oxygen [4]. In cell signaling and homeostasis, reactive oxygen species are formed as a natural byproduct of metabolism of oxygen [5].…”

Section: Reactive Oxygen Species Generationmentioning

confidence: 99%

Review on a Nanomaterials Mechanisms-Induced Oxidative Stress and Toxicity

Geetha¹,

Prabhavathi²,

Ayeshamariam³

et al. 2017

J Powder Metall Min

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The review reveals the recent trends of nano-materials in biomedical applications and an overview to discuss the commercialization of nano-materials. Due to innovative ideas in nano-materials created a lot of new discoveries in the medical, consumer sectors and industrial applications. The properties of nano-materials lead to a quite interest in a various applications in biomedical field such as structural and physicochemical properties. In a biological activity; toxicities of a nanoparticle are frequently reported. In the presence of acellular factors such as size, composition, particle surface and presence of metals in a nano-materials induces oxidative stress and it creates a pathway for patho physiological effects includes fibrosis, genotoxicity and injuries in a skin. Zinc oxide acts as an antioxidant for reducing oxidative stress and it acts as a protective agent for an immune system in a biomedical fields. This review summarizes biomedical applications of a nano-materials and the role of an oxidative stress.

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Superoxide Ion: Generation and Chemical Implications

Cited by 1,714 publications

References 660 publications

Vitreous Humour Lipid Peroxidation as an Emerging Concept of Acute Carbon Monoxide Poisoning

Vitreous Humour Lipid Peroxidation as an Emerging Concept of Acute Carbon Monoxide Poisoning

The role of oxidative stress and inflammatory response in the pathogenesis of mastitis in dairy cows

Review on a Nanomaterials Mechanisms-Induced Oxidative Stress and Toxicity

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