superoxide production by reoxygenated endothelial cells and its effect on the endothelial-neutrophil interaction.

Reperfusion Induces Sublethal Endothelial Injury

“…This reaction was thought to occur because Ca 2ϩ ions were abruptly transferred due to membrane injury induced by hypoxia/reoxygenation [24]. Zweier et al [25] demonstrated the rapid production of oxygen radicals by cultured ECs during reperfusion and we also reported that the initial production of O 2 Ϫ and H 2 O 2 by ECs occurred very rapidly after reoxygenation [26]. Free radicals may play a role in EC damage after reoxygenation.…”