Superoxidedismutase-mimetic copper(II) complexes containing saccharinate and 4-aminopyridine/4-cyanopyridine

Improvement of the antihypertensive capacity of candesartan and trityl candesartan by their SOD mimetic copper(II) complexes

“…13, it can be seen that the poor antioxidant capacities of the sartans were improved by complexation (IC 50 [1] =6.8×10 −6 M and IC 50 [2] = 3.7× 10 −6 M). The prepared mimetic complexes were not as effective as the enzyme (bovine erythrocyte SOD, IC 50 = 2.1× 10 −7 M) [41] but it has been previously determined that when the experimental IC 50 values occurred below 20 ×10 −6 M the compounds are considered to act as strong SOD mimics [42].…”

Development of copper based drugs, radiopharmaceuticals and medical materials

“…Many complexes of copper(II) have similar to SOD ability to neutralize superoxides ( 14 – 27 ). These SOD-mimicking complexes of copper were proposed as non-analgesic anti-inflammatory drugs by various authors: Cu complexes of aromatic acids ( 14 – 16 ) (Suksrichavalit et al 2008), saccharinate and pyridine derivates ( 17 – 18 ) (Ferrer et al 2010), tolfenamic acid ( 19 ) (Kovala-Demertzi et al 2004), 2-amino-2-thiazoline and polyamines ( 20 – 25 ) (Pontiki et al 2006), o-vanillin ( 26 ) (González-Baró et al 2010), oxaprozinate ( 27 ) (Dutta et al 2004). …”