Superparamagnetic and fluorescent thermo-responsive core–shell–corona hybrid nanogels with a protective silica shell

Nanogels: An overview of properties, biomedical applications and obstacles to clinical translation

“…Ruhland et al reported such nanogels that had a temperature-sensitive corona of crosslinked PNIPAAm. High magnetization and/or bright luminescence was achieved due to a core of maghemite and CdSe(ZnS) while the silica shell provided a strong protection to the core from degradation in conditions of extreme pH, thus giving these nanogels a potential for oral administration [198]. …”

Core–shell designed scaffolds for drug delivery and tissue engineering

“…6c). For example, it was previously shown that mesoporous silica nanoparticles coated with pNIPAAm presented a temperature dependent release profile, with significantly higher release at 37ºC than at room temperature [89] [90]. In a more biological approach, DNA was used as a coating for the nanoparticles, showing that when the temperature was increased and the DNA was denatured, the cargo within the nanoparticle was released [91].…”

“…One design is the use of MSN as the core and a polymer shell with stimuli-responsiveness, such as temperature and magnetism. MSN can be coated with pNIPAAm, showing a temperature dependent release of DOX [95] [89,92]. Likewise, a zwitterionic sulfobetaine copolymer was coated on the MSN, causing the release to be temperature dependent [96].…”

Steric stabilization of modified nanoclays triggered by temperature

“…The nanoparticles modification with thermo-sensitive polymer is usually done via grafting to ensure the polymer attachment and, consequently, to guarantee the stability of the hybrids; that is a rather important feature to the light of their applications within different fields [31]. Alternatively, modification of nanoparticles can be done by exploiting weak interactions (electrostatic, ion-dipole, dipole-dipole forces) that is valuable because it is a less consuming time procedure and it has a low environmental impact.…”