Superparamagnetic Iron Oxide Nanoparticles for Cancer Theranostic Applications

Maity, Dipak; Kandasamy, Ganeshlenin; Sudame, Atul

doi:10.1007/978-3-030-29768-8_12

Cited by 17 publications

(6 citation statements)

References 128 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Magnetic nanoparticles majorly include: manganite perovskites (La 1−x Sr x MnO 3 ) and spinel ferrites (especially, Fe 3 O 4 (iron oxide)) [46,47]. Among them, spinel ferrites possess attractive superparamagnetic characteristics, with magnetic and heat stimuliresponsiveness, for use in imaging and therapeutics [48,49]. For instance, superparamagnetic iron oxide nanoparticles (SPIOs) have been utilized as good: (i) T2 contrast agents for magnetic resonance imaging (MRI) [50][51][52][53], and (ii) heating agents in many magnetic hyperthermia cancer treatments [54][55][56][57][58].…”

Section: Major Types Of Inorganic Nanocarriers 211 Superparamagnetic ...mentioning

confidence: 99%

Inorganic nanocarriers for siRNA delivery for cancer treatments

Kandasamy,

Maity

2024

Biomed. Mater.

Self Cite

View full text Add to dashboard Cite

RNA interference (RNAi) is one of the emerging methodologies utilized in the treatment of a wide variety of diseases including cancer. This method specifically uses therapeutic RNAs (TpRNAs) like small interfering RNAs (siRNAs) to regulate/silence the cancer-linked genes, thereby minimizing distinct activities of cancer cells and aiding in their apoptosis. But, many complications arise during the transport/delivery of these TpRNAs that include poor systemic circulation, instability/degradation inside the body environment, no targeting capacity and also low cellular internalization. These difficulties can be overcome by using nanocarriers to deliver the TpRNAs inside the cancer cells. The following are the various categories of nanocarriers - viral vectors (e.g., lentivirus and adenovirus) and non-viral nanocarriers (self-assembling nanocarriers and inorganic nanocarriers). Viral vectors suffer from few disadvantages like high immunogenicity as compared to the non-viral nanocarriers. Among non-viral nanocarriers, inorganic nanocarriers gained significant attention as their inherent properties (like magnetic properties) can aid in effective cellular delivery of the TpRNAs. Most of the prior reports have discussed about the delivery of TpRNAs through self-assembling nanocarriers; however very few have reviewed about their delivery using the inorganic nanoparticles. Therefore, in this review, we have mainly discussed the delivery of TpRNAs – i.e., siRNA, especially programmed death ligand-1 (PD-L1), survivin, B-cell lymphoma-2 (Bcl-2), vascular endothelial growth factor (VEGF) and other siRNAs using the inorganic nanoparticles – mainly magnetic, metal and silica nanoparticles. Moreover, we have discussed about the combined delivery of these TpRNAs along with chemotherapeutic drugs (mainly doxorubicin) and in vitro and in vivo therapeutic effectiveness.

show abstract

Section: Major Types Of Inorganic Nanocarriers 211 Superparamagnetic ...mentioning

confidence: 99%

Inorganic nanocarriers for siRNA delivery for cancer treatments

Kandasamy,

Maity

2024

Biomed. Mater.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The multi-domain, single-domain and superparamagnetic regimes exhibit more magnetic behavior if the MNP size becomes smaller. 230,232 If the MNP is synthesized below the critical volume/size, it tends to be a single magnetic domain structure, whereas if it is bigger than Fig. 38 Particle size and its effect on magnetization.…”

Section: Magnetization In Micro and Nanoscale Materialsmentioning

confidence: 99%

Functionalized hybrid magnetic catalytic systems on micro- and nanoscale utilized in organic synthesis and degradation of dyes

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Because of their low cytotoxicity, biocompatibility, stability, and unique magnetic properties, they are extensively researched for theranostic purposes. Their possible applications include magnetic resonance imaging (as contrast agents), photothermal therapy, magnetic fluid hyperthermia, or radiotherapy [ 7 ]. Moreover, they can be easily tailored in size, morphology, and surface functionalization to give them appropriate application fields, e.g., as chemo- or immunotherapeutic carriers [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Red Flags and Adversities on the Way to the Robust CE-ICP-MS/MS Quantitative Monitoring of Self-Synthesized Magnetic Iron Oxide(II, III)-Based Nanoparticle Interactions with Human Serum Proteins

2022

View full text Add to dashboard Cite

The growing interest in superparamagnetic iron oxide nanoparticles (SPIONs) as potential theranostic agents is related to their unique properties and the broad range of possibilities for their surface functionalization. However, despite the rapidly expanding list of novel SPIONs with potential biomedical applications, there is still a lack of methodologies that would allow in-depth investigation of the interactions of those nanoparticles with biological compounds in human serum. Herein, we present attempts to employ capillary electrophoresis-inductively coupled plasma tandem mass spectrometry (CE-ICP-MS/MS) for this purpose and various obstacles and limitations noticed during the research. The CE and ICP-MS/MS parameters were optimized, and the developed method was used to study the interactions of two different proteins (albumin and transferrin) with various synthesized SPIONs. While the satisfactory resolution between proteins was obtained and the method was applied to examine individual reagents, it was revealed that the conjugates formed during the incubation of the proteins with SPIONs were not stable under the conditions of electrophoretic separation.

show abstract

Superparamagnetic Iron Oxide Nanoparticles for Cancer Theranostic Applications

Cited by 17 publications

References 128 publications

Inorganic nanocarriers for siRNA delivery for cancer treatments

Inorganic nanocarriers for siRNA delivery for cancer treatments

Functionalized hybrid magnetic catalytic systems on micro- and nanoscale utilized in organic synthesis and degradation of dyes

Red Flags and Adversities on the Way to the Robust CE-ICP-MS/MS Quantitative Monitoring of Self-Synthesized Magnetic Iron Oxide(II, III)-Based Nanoparticle Interactions with Human Serum Proteins

Contact Info

Product

Resources

About