Superparamagnetic iron oxide nanoparticles (SPIONs) as a multifunctional tool in various cancer therapies

Musielak, Marika; Piotrowski, Igor; Suchorska, Wiktoria Maria

doi:10.1016/j.rpor.2019.04.002

Cited by 46 publications

(19 citation statements)

References 94 publications

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“…Over the past several years, there has been a great development of iron oxide-based magnetic nanoparticles application in many scientific fields, including biomedical engineering [ 1 , 2 ], cell labeling [ 3 , 4 ], cancer treatment [ 5 , 6 , 7 ], magnetic drug delivery [ 8 , 9 ], multimodal imaging [ 10 , 11 ], and Magnetic Resonance Imaging (MRI) contrast agents [ 12 , 13 , 14 ], due to their unique and diverse biomedical properties. Depending on their composition and surface modification, they recently focused attention on the targeted anticancer treatment and mild magnetic hyperthermia (MH) [ 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Hybrid System for Local Drug Delivery and Magnetic Hyperthermia Based on SPIONs Loaded with Doxorubicin and Epirubicin

et al. 2021

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Cancer is one of the most common causes of death worldwide, thus new solutions in anticancer therapies are highly sought after. In this work, superparamagnetic iron oxide nanoparticles (SPIONs) conjugated with anticancer drugs are synthesized and investigated as potential magnetic drug nanocarriers for local drug delivery and mild magnetic hyperthermia. We have obtained a hybrid system loaded with holmium and anticancer drugs and thoroughly studied it with respect to the size, morphology, surface modifications and magnetic properties, and interactions with the model of biological membranes, cytotoxicity. We present that nanoparticles having a round shape and size 15 nm are successfully stabilized to avoid their agglomeration and modified with doxorubicin or epirubicin within a controlled way. The number of drugs loaded into the SPIONs was confirmed with thermogravimetry. The hybrid based on SPIONs was investigated in touch with model biological membranes within the Langmuir-Blodgett technique, and results show that modified SPION interacts effectively with them. Results obtained with magnetic hyperthermia and biological studies confirm the promising properties of the hybrid towards future cancer cell treatment.

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Section: Introductionmentioning

confidence: 99%

Hybrid System for Local Drug Delivery and Magnetic Hyperthermia Based on SPIONs Loaded with Doxorubicin and Epirubicin

et al. 2021

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“…Lipos were synthesized following the identical protocol [19] with small modifications to achieve a smaller size of liposomes. The estimated mean diameter of the whole structure was 100-120 nm, where the coating was created by gold nanoparticles of the 5-8 nm diameter ensuring the renal clearance after biodegradation of core liposome [92]. Lipos Au NPs were injected i.v.…”

Section: Medical Imagingmentioning

confidence: 99%

“…Therefore, SPIONs size control is a critical challenge for their application in MR imaging. Regarding the agglomeration problem, it can be controlled by coating SPIONs, e.g., with polymers or lipids [92].…”

Section: Medical Imagingmentioning

confidence: 99%

The Combination of Liposomes and Metallic Nanoparticles as Multifunctional Nanostructures in the Therapy and Medical Imaging—A Review

Musielak

Potoczny

Boś-Liedke

et al. 2021

IJMS

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Nanotechnology has introduced a new quality and has definitely developed the possibilities of treating and diagnosing various diseases. One of the scientists’ interests is liposomes and metallic nanoparticles (LipoMNPs)—the combination of which has introduced new properties and applications. However, the field of creating hybrid nanostructures consisting of liposomes and metallic nanoparticles is relatively little understood. The purpose of this review was to compile the latest reports in the field of treatment and medical imaging using of LipoMNPs. The authors focused on presenting this issue in the direction of improving the used conventional treatment and imaging methods. Most of all, the nature of bio-interactions between nanostructures and cells is not sufficiently taken into account. As a result, overcoming the existing limitations in the implementation of such solutions in the clinic is difficult. We concluded that hybrid nanostructures are used in a very wide range, especially in the treatment of cancer and magnetic resonance imaging. There were also solutions that combine treatments with simultaneous imaging, creating a theragnostic approach. In the future, researchers should focus on the description of the biological interactions and the long-term effects of the nanostructures to use LipoMNPs in the treatment of patients.

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“…Nanoparticles offer remarkable possibilities in terms of their electronic, optical, and magnetic properties, which have the potential to produce improved therapeutics and medical devices [ 51 ]. In this regard, inorganic nanoparticles have been widely considered as a platform for the development of tools for targeted drug delivery, clinical diagnostics, and medical imaging.…”

Section: Magnetite Nanoparticles—synthesis Properties and Functimentioning

confidence: 99%

Magnetite Nanoparticles and Essential Oils Systems for Advanced Antibacterial Therapies

Mihai

Chircov

Grumezescu

et al. 2020

IJMS

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Essential oils (EOs) have attracted considerable interest in the past few years, with increasing evidence of their antibacterial, antiviral, antifungal, and insecticidal effects. However, as they are highly volatile, the administration of EOs to achieve the desired effects is challenging. Therefore, nanotechnology-based strategies for developing nanoscaled carriers for their efficient delivery might offer potential solutions. Owing to their biocompatibility, biodegradability, low toxicity, ability to target a tissue specifically, and primary structures that allow for the attachment of various therapeutics, magnetite nanoparticles (MNPs) are an example of such nanocarriers that could be used for the efficient delivery of EOs for antimicrobial therapies. The aim of this paper is to provide an overview of the use of EOs as antibacterial agents when coupled with magnetite nanoparticles (NPs), emphasizing the synthesis, properties and functionalization of such NPs to enhance their efficiency. In this manner, systems comprising EOs and MNPs could offer potential solutions that could overcome the challenges associated with biofilm formation on prosthetic devices and antibiotic-resistant bacteria by ensuring a controlled and sustained release of the antibacterial agents.

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Superparamagnetic iron oxide nanoparticles (SPIONs) as a multifunctional tool in various cancer therapies

Cited by 46 publications

References 94 publications

Hybrid System for Local Drug Delivery and Magnetic Hyperthermia Based on SPIONs Loaded with Doxorubicin and Epirubicin

Hybrid System for Local Drug Delivery and Magnetic Hyperthermia Based on SPIONs Loaded with Doxorubicin and Epirubicin

The Combination of Liposomes and Metallic Nanoparticles as Multifunctional Nanostructures in the Therapy and Medical Imaging—A Review

Magnetite Nanoparticles and Essential Oils Systems for Advanced Antibacterial Therapies

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