Superparamagnetic Magnetite Nanoparticles for Cancer Theranostics

Kleinauskas, Andrius; Kim, Jongki; Choi, Gi-Hwan; Kim, Hong-Tae; Røe, Kathrine; Juzenas, Petras

doi:10.1166/rnn.2012.1018

Cited by 13 publications

(11 citation statements)

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“…In our study, it was shown that the viability percentage in MGU87 cells treated with ZNO nanoparticle alone was not different to other cells received this nanoparticle and different 2, 4, and 6 Gy doses of X-ray. In fact, irradiating cells previously receiving ZnO nanoparticle may not led to a synergistic effect that is consistent with a study performed in 2012 that showed lower effect of using X-ray with the source of LINAC and FeO nanoparticles in comparison with monochromatic radiation (7% versus 50% to 70%) (Kleinauskas et al, 2012;Pradhan et al, 2009). We also showed no difference in cellular viability between the cells receiving different doses of X-ray without ZnO nanoparticle.…”

Section: Discussionsupporting

confidence: 92%

Evaluation of glioblastoma (U87) treatment with ZnO nanoparticle and X-ray in spheroid culture model using MTT assay

Sadri

Changizi

Eivazadeh

2015

Radiation Physics and Chemistry

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Section: Discussionsupporting

confidence: 92%

Evaluation of glioblastoma (U87) treatment with ZnO nanoparticle and X-ray in spheroid culture model using MTT assay

Sadri

Changizi

Eivazadeh

2015

Radiation Physics and Chemistry

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“…Radio sensitizing effect of super paramagnetic nanoparticles was examined extensively with respect to broad band x-rays in previous report [17]. High energy X-ray from LINAC source did not show dose enhancement significantly upon irradiation on iron nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Photon activated therapy (PAT) using monochromatic Synchrotron x-rays and iron oxide nanoparticles in a mouse tumor model: feasibility study of PAT for the treatment of superficial malignancy

et al. 2012

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BackgroundX-rays are known to interact with metallic nanoparticles, producing photoelectric species as radiosensitizing effects, and have been exploited in vivo mainly with gold nanoparticles. The purpose of this study was to investigate the potential of sensitizing effect of iron oxide nanoparticles for photon activated therapy.MethodsX-rays photon activated therapy (PAT) was studied by treating CT26 tumor cells and CT26 tumor-bearing mice loaded with 13-nm diameter FeO NP, and irradiating them at 7.1 keV near the Fe K-edge using synchrotron x-rays radiation. Survival of cells was determined by MTT assay, and tumor regression assay was performed for in vivo model experiment. The results of PAT treated groups were compared with x-rays alone control groups.ResultsA more significant reduction in viability and damage was observed in the FeO NP-treated irradiated cells, compared to the radiation alone group (p < 0.04). Injection of FeO NP (100 mg/kg) 30 min prior to irradiation elevated the tumor concentration of magnetite to 40 μg of Fe/g tissue, with a tumor-to-muscle ratio of 17.4. The group receiving FeO NP and radiation of 10 Gy showed 80% complete tumor regression (CTR) after 15–35 days and relapse-free survival for up to 6 months, compared to the control group, which showed growth retardation, resulting in 80% fatality. The group receiving radiation of 40 Gy showed 100% CTR in all cases irrespective of the presence of FeO NP, but CTR was achieved earlier in the PAT-treated group compared with the radiation alone group.ConclusionsAn iron oxide nanoparticle enhanced therapeutic effect with relatively low tissue concentration of iron and 10 Gy of monochromatic X-rays. Since 7.1 keV X-rays is attenuated very sharply in the tissue, FeO NP-PAT may have promise as a potent treatment option for superficial malignancies in the skin, like chest wall recurrence of breast cancer.

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“…It also should be pointed out that nanomedicine has become a hot area that under extensive investigations. [213][214][215][216][217][218][219][220][221][222][223][224][225][226][227][228][229] In addition to use nanoparticles for radiation enhancement discussed above, the combination of radiotherapy and photodynamic therapy via nanoparticles have been proposed and investigated. 220-229 Nanomedicine will have a bright future and will help to accelerate the progress toward ending cancers.…”

Section: Cscs Biomarkersmentioning

confidence: 99%

Active Targeting of Nano-Photosensitizer Delivery Systems for Photodynamic Therapy of Cancer Stem Cells

Lin¹,

Li²,

Wen³

et al. 2015

j biomed nanotechnol

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Cancer stem cells are believed to be the basis for tumor initiation, development, metastasis and recurrence; are resistant to most traditional therapies (e.g., chemotherapy and radiotherapy); and have the ability to self-renew, proliferate and differentiate. Photodynamic therapy may be a promising novel treatment for drug-resistant cancer stem cells because of the selectivity of the photosensitizer. One of the most important issues to overcome in photodynamic therapy is the photosensitizer-targeted delivery to tumor cells, especially cancer stem cells. Nano-photosensitizers comprising molecular photosensitizers and water-dispersible nanocarriers with or without moieties possessing the ability for specific binding to cancer cells or cancer stem cells are a promising strategy for active targeted photosensitizer delivery and photodynamic therapy-targeted therapy of tumors. In this review, we highlight current and future prospects for potential strategies based on nanoscience and nanotechnology for nano-photosensitizer-targeted delivery in the photodynamic therapy treatment of cancer cells, especially cancer stem cells.

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Superparamagnetic Magnetite Nanoparticles for Cancer Theranostics

Cited by 13 publications

References 0 publications

Evaluation of glioblastoma (U87) treatment with ZnO nanoparticle and X-ray in spheroid culture model using MTT assay

Evaluation of glioblastoma (U87) treatment with ZnO nanoparticle and X-ray in spheroid culture model using MTT assay

Photon activated therapy (PAT) using monochromatic Synchrotron x-rays and iron oxide nanoparticles in a mouse tumor model: feasibility study of PAT for the treatment of superficial malignancy

Active Targeting of Nano-Photosensitizer Delivery Systems for Photodynamic Therapy of Cancer Stem Cells

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