Calcium (Ca), with abundant and cheap reserves, is a potential element to facilitate the further application of Mg-Al-Sn based alloys. Here, effects of Ca content on the microstructure and tensile properties of Mg-2.0Al-0.8Sn (wt.%) alloys were systematically studied. The experimental results illustrated that the strength, ductility and isotropy of the alloys improved simultaneously with the increase of Ca content. The better ductility and isotropy could be contributed to the weakened texture via particle stimulation nucleation mechanism. The higher strength benefited from the combination of finer grains, more precipitates and residual dislocation density. Eventually, the Mg-2.0Al-0.8Sn-0.5Ca (wt.%) alloy showed the best room-temperature balance of strength and ductility with a yield strength of ∼226.0 MPa, an ultimate tensile strength of ∼282.4 MPa and a fracture elongation of ∼20.2%, which has huge potential as an applicable low-cost high-performance magnesium alloy.