Superpulsed 904 nm laser photobiomodulation combined with coenzyme Q10 synergistically augment burn wound healing

Yadav, Anju; Priyadarshi, Ashok; Keshri, Gaurav K.; Verma, Saurabh; Gupta, Asheesh

doi:10.1016/j.jpap.2021.100053

Cited by 8 publications

(18 citation statements)

References 44 publications

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“…The rat was anesthetized using an intraperitoneal injection of ketamine and xylazine cocktail in the proportion of 90:10 mg/kg. As reported previously, a third‐degree transdermal burn wound was created on the dorsal side of the rats under aseptic conditions, except for the uninjured skin group of rats 10 . Briefly, the hairs were removed from the dorsal surface of the rats, and the underlying skin was cleaned with ethanol (70%).…”

Section: Methodsmentioning

confidence: 99%

“…Operation mode of PBMT can either be continuous, pulsed, or superpulsed wave. Superpulsed laser consecutively emits relatively strong high‐powered light in nano/picosecond pulses, and deeper tissue penetration in a non‐thermal way 10–12 . Recent studies have manifested that 904 nm superpulsed laser dynamically improved impaired wound healing 11,13 …”

Section: Introductionmentioning

confidence: 99%

“…Hence, currently, these combined therapies are a focus of investigation globally. Several studies use PBMT as one of the treatment strategies in combination with different bioactive compounds/natural products like arginine, vitamin A, lactate, pyruvate, coenzyme Q10 (Co‐Q10), curcumin, and honey to improve the curing rate of the non‐healing wounds 10,14–21 …”

Section: Introductionmentioning

confidence: 99%

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Effect of combination of photobiomodulation 904 nm superpulsed laser therapy and Hippophae rhamnoides L. on third‐degree burn wound healing

Priyadarshi

Keshri

Gupta

2023

J of Cosmetic Dermatology

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BackgroundBurn is a traumatic injury and aesthetic scarless repair poses a great challenge in area of cosmetic dermatology. Focus on multimode therapeutic strategies to promote healing of burns by regulating various stages of healing is warranted. Photobiomodulation therapy (PBMT), a non‐invasive modality grabs the attention to repair impaired wounds. Seabuckthorn extract (SBTL‐ALE) is known to possess antioxidant, anti‐inflammation, and tissue‐repair abilities. Current study aims to assess the effect of combination treatment of PBM 904 nm superpulsed laser and SBTL‐ALE (2.5%) on repair of third‐degree burn in rats.MethodsRats were randomized into five groups: uninjured, control, SBTL‐ALE, 904 nm PBMT, and combination. A transdermal burn wound was induced on the dorsal side of rats of all groups except the uninjured group and respective treatment was applied for 7 days postwounding.ResultsDual treatment increased wound area contraction compared to control and either treatment alone. Immunohistochemical analyses exhibited increased angiogenesis, dermal hydration, collagen synthesis, and maintained redox homeostasis as evidenced by enhanced expression (p < 0.05) of CD31, aquaporin3, collagen type 3, Nrf2, and HO1 in combination group compared with control. Conversely, pro‐inflammatory and oxidative stress markers exhibited reduced (p < 0.05) TNF‐α, IL‐6, IL‐1β, NOS‐2, ROS levels, and increased catalase activity in combined treatment. Furthermore, energy metabolizing enzymes viz. citrate synthase, CCO, and ATP contents were substantially (p < 0.05) increased, and LDH activity was reduced in the combination group.ConclusionsDual treatment (PBMT + SBTL‐ALE) prominently accelerates third‐degree burn wound healing in rats, which could pave the path for multimode therapeutic strategies for the management of burns and dermal cosmetic care.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of combination of photobiomodulation 904 nm superpulsed laser therapy and Hippophae rhamnoides L. on third‐degree burn wound healing

Priyadarshi

Keshri

Gupta

2023

J of Cosmetic Dermatology

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“…[ 3–8 ] Coenzyme Q10 and 904 nm superpulse‐mediated photobiomodulation (PBM) were found to accelerate the healing of large area burns. [ 9 ] Coenzyme Q10 has a wide application prospect in the field of medicine due to its high safe dose and low toxic and side effects. [ 10,11 ]…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5][6][7][8] Coenzyme Q10 and 904 nm superpulse-mediated photobiomodulation (PBM) were DOI: 10.1002/crat.202100270 found to accelerate the healing of large area burns. [9] Coenzyme Q10 has a wide application prospect in the field of medicine due to its high safe dose and low toxic and side effects. [10,11] According to the statistics of pharmacopoeia, more than 85% of drug products are solid drugs, except for a few amorphous products, the vast majority is crystal products.…”

Section: Introductionmentioning

confidence: 99%

Development and Optimization of Antisolvent Cooling Coupled Crystallization Process for Coenzyme Q10

Liu

et al. 2022

Crystal Research and Technology

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The solubility of coenzyme Q10 in binary mixed solvents (tetrahydrofuran (THF) + ethanol) is determined at the temperature range from 278.15 to 313.15 K by static high-performance liquid chromatography. The super-solubility of coenzyme Q10 at f C = 0.4(C is ethanol), f C = 0.6, f C = 0.8 is measured by dynamic laser method, thus the metastable zone of coenzyme Q10 in binary mixed solvent (THF + ethanol) is obtained. The measurement results show that the solubility of coenzyme Q10 and the width of the metastable zone increase with the increasing of temperature and increasing of THF content in the mixed solvent. Coenzyme Q10 antisolvent cooling coupled crystallization process is developed based on thermodynamic data, and the crystallization conditions are investigated experimentally. The diameter span of crystal size distribution decreases from 5.542 to 1.981 and the median particle size (Dv50) increases from 41.8 to 81.3 𝝁m, which means that the crystal products of coenzyme Q10 are improved by adjusting the crystallization process parameters.

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Pretreatment with combined low-level laser therapy and methylene blue improves learning and memory in sleep-deprived mice

2022

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Superpulsed 904 nm laser photobiomodulation combined with coenzyme Q10 synergistically augment burn wound healing

Cited by 8 publications

References 44 publications

Effect of combination of photobiomodulation 904 nm superpulsed laser therapy and Hippophae rhamnoides L. on third‐degree burn wound healing

Effect of combination of photobiomodulation 904 nm superpulsed laser therapy and Hippophae rhamnoides L. on third‐degree burn wound healing

Development and Optimization of Antisolvent Cooling Coupled Crystallization Process for Coenzyme Q10

Pretreatment with combined low-level laser therapy and methylene blue improves learning and memory in sleep-deprived mice

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