Superselective arterial embolization of the superior mesenteric artery for the treatment of gastrointestinal hemorrhage following allogeneic hematopoietic stem cell transplantation

Chen, Runzhe; Zhao, Gang; Jin, Nan; Chen, Baoan; Ding, Jia-Hua

doi:10.2147/ppa.s72875

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…Continuous infusion of octreotide has been studied for the treatment of GVHD-related gastrointestinal bleeding, but its efficacy is lost when the drug is discontinued 172 . In the setting of ongoing bleeding that cannot be managed with conservative approaches, cases of successful arterial embolization have been reported 173 . Another technique is intra-arterial platelet transfusion 174 .…”

Section: Managementmentioning

confidence: 99%

Acute graft-versus-host disease of the gut: considerations for the gastroenterologist

Naymagon

Wong

et al. 2017

Nat Rev Gastroenterol Hepatol

126

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Haematopoietic stem cell transplantation (HSCT) is central to the management of many haematological disorders. A frequent complication of HSCT is acute graft-versus-host disease (GVHD), a condition in which immune cells from the donor attack healthy recipient tissues. The gastrointestinal system is among the most common sites affected by acute GVHD, and severe manifestations of acute GVHD of the gut portends a poor prognosis in patients after HSCT. Acute GVHD of the gastrointestinal tract presents both diagnostic and therapeutic challenges. Although the clinical manifestations are nonspecific and overlap with those of infection and drug toxicity, diagnosis is ultimately based on clinical criteria. As reliable serum biomarkers have not yet been validated outside of clinical trials, endoscopic and histopathological evaluation continue to be utilized in diagnosis. Once a diagnosis of gastrointestinal acute GVHD is established, therapy with systemic corticosteroids is typically initiated, and non-responders can be treated with a wide range of second-line therapies. In addition to treating the underlying disease, the management of complications including profuse diarrhoea, severe malnutrition and gastrointestinal bleeding is paramount. In this Review, we discuss strategies for the diagnosis and management of acute GVHD of the gastrointestinal tract as they pertain to the practising gastroenterologist.

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Section: Managementmentioning

confidence: 99%

Acute graft-versus-host disease of the gut: considerations for the gastroenterologist

Naymagon

Wong

et al. 2017

Nat Rev Gastroenterol Hepatol

126

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“…Surgical literature has demonstrated that surgical intervention provides, at best, temporarily cessation of hemorrhage in patients with UGIB related to GVHD. [40][41][42] While gastrointestinal hemorrhage following bone marrow transplantation is relatively low, 10%, 43,44 acute UGIB from GVHD has reported mortality rates as high as 30 to 60%. 43,45 While UGIB can be effectively controlled with transcatheter arterial embolization, patients with bleeding related to GVHD should be approached with treatment strategies that take into consideration the diffuse nature of this disease and the near universal presence of severe refractory thrombocytopenia.…”

Section: Procedural Outcomes and Complicationsmentioning

confidence: 99%

Embolization of Nonvariceal Upper Gastrointestinal Hemorrhage Complicated by Bowel Ischemia

Foltz

Khaddash

2019

Semin intervent Radiol

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Over the past three decades, transcatheter arterial embolization has become the first-line therapy for the management of acute nonvariceal upper gastrointestinal bleeding refractory to endoscopic hemostasis. Overall, transcatheter arterial interventions have high technical and clinical success rates. This review will focus on patient presentation and technical considerations as predictors of complications from transcatheter arterial embolization in the management of acute upper gastrointestinal hemorrhage.

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Superselective arterial embolization of the superior mesenteric artery for the treatment of gastrointestinal hemorrhage following allogeneic hematopoietic stem cell transplantation

Cited by 2 publications

References 22 publications

Acute graft-versus-host disease of the gut: considerations for the gastroenterologist

Acute graft-versus-host disease of the gut: considerations for the gastroenterologist

Embolization of Nonvariceal Upper Gastrointestinal Hemorrhage Complicated by Bowel Ischemia

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