Superselective Intraophthalmic Artery Chemotherapy in a Nonhuman Primate Model

Tse, Brian C.; Steinle, Jena J.; Johnson, Dianna A.; Haik, Barrett G.; Wilson, Matthew W.

doi:10.1001/jamaophthalmol.2013.2065

Cited by 43 publications

(33 citation statements)

References 22 publications

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“…Although no significant ocular side effects have been reported with intravenous chemotherapy, intraarterial chemotherapy has been associated with rare cases of vision loss and choroidal and arterial occlusion. A monkey model of intraarterial chemotherapy has demonstrated evidence of vascular endothelial toxicity and diffuse retinal deposits following treatment …”

Section: Discussionmentioning

confidence: 99%

Long‐term outcomes of Group D retinoblastoma eyes during the intravitreal melphalan era

Berry

Shah

Bechtold

et al. 2017

Pediatric Blood & Cancer

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Section: Discussionmentioning

confidence: 99%

Long‐term outcomes of Group D retinoblastoma eyes during the intravitreal melphalan era

Berry

Shah

Bechtold

et al. 2017

Pediatric Blood & Cancer

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“…Success with IAC requires skill and experience. Most centers have difficulty with the first several catheterizations, leading to potential vascular obstruction and vision loss [55,56]. An overall assessment of complications with 5-year experience included vitreous hemorrhage (2%), branch retinal artery obstruction (1%), ophthalmic artery spasm with reperfusion (2%), ophthalmic artery obstruction (2%), partial choroidal ischemia (2%), and optic neuropathy (<1%) [48 && ] (Table 4).…”

Section: When To Use Intra-arterial Chemotherapymentioning

confidence: 99%

Targeted retinoblastoma management

Shields

Lally

Leahey

et al. 2014

Current Opinion in Ophthalmology

144

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“…The vascular toxicity may be related to the pH, the pulsatile delivery or the chemotherapeutic drugs used 17. In a non-human primate model, the retinal arterioles revealed smudging of the endothelial cells and their basement membranes with terminal vessel occlusion 18. Maidana et al 19 have reported thinning of the choroid after IAC, as accessed by optical coherence tomography.…”

Section: Discussionmentioning

confidence: 99%

Retrobulbar ocular blood flow changes measured by colour Doppler imaging after intra-arterial chemotherapy in retinoblastoma

et al. 2017

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Purpose To evaluate the effects of intra-arterial chemotherapy on retrobulbar blood flow parameters in patients with retinoblastoma. Methods 20 eyes of 10 patients with unilateral retinoblastoma that were treated with intra-arterial chemotherapy were evaluated using colour Doppler imaging. The peak systolic and end-diastolic velocities of the ophthalmic, central retinal and posterior ciliary arteries were determined. The pulsatility and resistance indices were calculated automatically. The treated eye was compared with the untreated (control) eye and with itself before and after intra-arterial chemotherapy.Results When comparing the retinoblastomacontaining eyes with the contralateral normal eyes, the peak systolic and end-diastolic velocities of the central retinal artery were significantly higher in the tumorous eyes than in the normal eyes before intra-arterial chemotherapy. Moreover, the peak systolic and enddiastolic velocities in the posterior ciliary and central retinal arteries were significantly decreased after intraarterial chemotherapy in the tumorous eyes ( p<0.05). There were no statistically significant differences in the other parameters. Conclusions Our results suggest that intra-arterial chemotherapy has a measurable effect on the retrobulbar blood flow, which can cause a decrease in the peak systolic and end-diastolic velocities in the posterior ciliary and central retinal arteries.

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Superselective Intraophthalmic Artery Chemotherapy in a Nonhuman Primate Model

Cited by 43 publications

References 22 publications

Long‐term outcomes of Group D retinoblastoma eyes during the intravitreal melphalan era

Long‐term outcomes of Group D retinoblastoma eyes during the intravitreal melphalan era

Targeted retinoblastoma management

Retrobulbar ocular blood flow changes measured by colour Doppler imaging after intra-arterial chemotherapy in retinoblastoma

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