Superselective pseudo-continuous arterial spin labeling angiography

Jensen‐Kondering, Ulf; Lindner, Thomas; Osch, Matthias J.P. van; Rohr, Axel; Jansen, Olav; Helle, Michael

doi:10.1016/j.ejrad.2015.05.034

Cited by 35 publications

(35 citation statements)

References 33 publications

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“…This could be mitigated to some degree in cases where only a few arterial branches are of interest, because the SNR efficiency loss of single‐artery methods scales with the square root of the number of targeted vessels . However, in the AVM data shown here and in another study, several arterial branches often supply the lesion, and nearby branches may also need to be targeted to exclude their involvement.…”

Section: Discussionmentioning

confidence: 96%

“…An alternative approach for these kinds of acquisitions is single‐artery selective ASL, which has also been used successfully above the circle of Willis in healthy volunteers and AVM patients . These techniques have the advantage of being relatively simple to prescribe and postprocess, and also allow the labeling plane to be reoriented to best suit each targeted artery.…”

Section: Discussionmentioning

confidence: 99%

“…Arterial spin labeling (ASL) is an MRI‐based technique that can be used to obtain vessel‐selective information noninvasively and without contrast agents. Single‐artery selective ASL techniques label blood flowing in individually targeted arterial branches of interest . Whilst being relatively simple to plan and postprocess, SNR efficiency is reduced compared with conventional nonselective ASL because the labeled blood is restricted to a single artery at a time.…”

Section: Introductionmentioning

confidence: 99%

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Visualizing artery‐specific blood flow patterns above the circle of Willis with vessel‐encoded arterial spin labeling

Okell

Garcia

Chappell

et al. 2018

Magnetic Resonance in Med

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Purpose To establish the feasibility of using vessel‐encoded pseudocontinuous arterial spin labeling (VEPCASL) for noninvasive vascular territory imaging (VTI) and artery‐specific dynamic angiography of a large number of arterial branches above the circle of Willis within a clinically feasible scan time. Methods 3D time‐of‐flight angiography was used to select a labeling plane and establish 7 pairs of encoding cycles. These were used for VEPCASL VTI and dynamic 2D angiography (8 min and 3 min acquisition times, respectively) in healthy volunteers, allowing the separation of signals arising from 13 arterial branches (including extracranial arteries) in postprocessing. To demonstrate the clinical potential of this approach, VEPCASL angiography was also applied in 5 patients with brain arteriovenous malformation (AVM). Results In healthy volunteers, the artery‐specific filling of the vascular tree and resulting perfusion territories were well depicted. SNRs were approximately 5 times higher than those achievable with single‐artery selective methods. Blood supply to the AVMs was well visualized in all cases, showing the main feeding arteries and venous drainage. Conclusions VEPCASL is a highly efficient method for both VTI and dynamic angiography of a large number of arterial branches, providing a comprehensive picture of vascular flow patterns and the effect on downstream tissue perfusion within an acceptable scan time. Automation of labeling plane and vessel‐encoding selection would improve robustness and efficiency, and further refinement could allow quantitative blood flow measurements to be obtained. This technique shows promise for visualizing the blood supply to lesions and collateral flow patterns.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Visualizing artery‐specific blood flow patterns above the circle of Willis with vessel‐encoded arterial spin labeling

Okell

Garcia

Chappell

et al. 2018

Magnetic Resonance in Med

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“…For example, vessel‐selective imaging that exclusively visualizes the downstream arterial tree of an individually targeted artery, can be achieved by applying spatially‐selective labeling pulses. Several previous studies report the usefulness of such vessel‐selective MRA, for example, for detecting the feeding arteries of an AVM . Also, ASL has a higher flexibility to achieve both high temporal and spatial resolution, because it is not limited to capture all necessary information during the first passage of a bolus of contrast agent.…”

Section: Introductionmentioning

confidence: 99%

“…Several previous studies report the usefulness of such vessel-selective MRA, for example, for detecting the feeding arteries of an AVM. 1,2 Also, ASL has a higher flexibility to achieve both high temporal and spatial resolution, because it is not limited to capture all necessary information during the first passage of a bolus of contrast agent. Therefore, ASL data acquisition can be repeated until sufficient information is acquired to achieve the desired spatial and temporal resolution.…”

Section: Introductionmentioning

confidence: 99%

Acceleration of vessel‐selective dynamic MR Angiography by pseudocontinuous arterial spin labeling in combination with Acquisition of ConTRol and labEled images in the Same Shot (ACTRESS)

Suzuki

Okell

Fujima

et al. 2018

Magnetic Resonance in Med

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Purpose The recently introduced “Acquisition of ConTRol and labEled imaging in the Same Shot” (ACTRESS) approach was designed to halve the scan time of arterial spin labeling (ASL) ‐based 4D‐MRA by obtaining both labeled and control images in a single Look‐Locker readout. However, application for vessel‐selective labeling remains difficult. The aim of this study was to achieve a combination of ACTRESS and vessel‐selective labeling to halve the scan time of vessel‐selective 4D‐MRA. Methods By Bloch equation simulations, Look‐Locker pseudocontinuous‐ASL (pCASL) was optimized to achieve constant static tissue signal across the multidelay readout, which is essential for the ACTRESS approach. Additionally, a new subtraction scheme was proposed to achieve visualization of the inflow phase even when labeled blood will have already arrived in the distal arteries during the first phase acquisition due to the long duration of the pCASL labeling module. In vivo studies were performed to investigate the signal variation of the static tissue, as well as to assess image quality of vessel‐selective 4D‐MRA with ACTRESS. Results In in vivo studies, the mean signal variation of the static tissue was 8.98% over the Look‐Locker phases, thereby minimizing the elevation of background signal. This allowed visualization of peripheral arteries and slowly arriving arterial blood with image quality as good as conventional pCASL within half the acquisition time. Vessel‐selective pCASL‐ACTRESS enabled the separated visualization of vessels arising from internal and external carotid arteries within this shortened acquisition time. Conclusion By combining vessel‐selective pCASL and ACTRESS approach, 4D‐MRA of a single targeted arterial tree was achieved in a few minutes.

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Utility of noncontrast‐enhanced time‐resolved four‐dimensional MR angiography with a vessel‐selective technique for intracranial arteriovenous malformations

Fujima

Osanai

Shimizu

et al. 2016

Magnetic Resonance Imaging

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Superselective pseudo-continuous arterial spin labeling angiography

Cited by 35 publications

References 33 publications

Visualizing artery‐specific blood flow patterns above the circle of Willis with vessel‐encoded arterial spin labeling

Visualizing artery‐specific blood flow patterns above the circle of Willis with vessel‐encoded arterial spin labeling

Acceleration of vessel‐selective dynamic MR Angiography by pseudocontinuous arterial spin labeling in combination with Acquisition of ConTRol and labEled images in the Same Shot (ACTRESS)

Utility of noncontrast‐enhanced time‐resolved four‐dimensional MR angiography with a vessel‐selective technique for intracranial arteriovenous malformations

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