Supersensitivity of Amylase Secretion from Rat Parotid Tissue—Its Selective Nature for the β2-Adrenergic Response

Hata, Fumiaki; Noguchi, Yutaka; Ishikawa, Yasuko; Koda, Naohiko; Ishida, Hideyuki

doi:10.1254/jjp.37.129

Cited by 6 publications

(1 citation statement)

References 11 publications

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“…Takayanagi et al (1977) found that procaterol increased tissue levels of cyclic AMP and that this action was greater in the guinea-pig trachea than in the atria and was prevented by prior application of propranolol. The P2-adrenoceptor agonist action of procaterol was confirmed in various tissues (vascular and cardiac tissues; Borkowski & Quinn, 1984;lung;Delhaye et al, 1983, parotid gland;Hata et al, 1985).…”

Section: Introductionmentioning

confidence: 93%

Relaxing actions of procaterol, a β₂‐adrenoceptor stimulant, on smooth muscle cells of the dog trachea

Fujiwara

Sumimoto

Itoh

et al. 1988

British J Pharmacology

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1 The effects of procaterol, a P2-adrenoceptor agonist, on smooth muscle cells of the dog trachea were investigated by use ofmicroelectrode and isometric tension recording methods, and by measurement of Ca transients as estimated fromthe fura-2 fluorescence, adenosine 3': 5'-cyclic monophosphate (cyclic AMP) and breakdown of phosphatidylinositols. 2 Procaterol hyperpolarized the membrane and increased the ionic conductance (above 10 nM) in a dose-dependent manner. These actions were inhibited by propranolol. 3 Procaterol inhibited the mechanical responses evoked by acetylcholine (ACh), histamine or 5-hydroxytryptamine (5-HT), in the presence or absence of Ca2+ in the bath solution, but not that evoked by high concentrations of ACh (1 JiM). The ID_,0 value of procaterol for the peak amplitude of the ACh-induced contraction (30 nM) was 0.3 nM. The equivalent values for the histamine-induced phasic and tonic responses (10I1M) were 0.15 and 0.01 nM), respectively. 4 Procaterol (over 1 nM) increased the amount ofcyclic AMP in a dose-dependent manner which was blocked by prior application of propranolol. 5 Procaterol did not alter the changes in the amounts of phosphatidylinositol 4,5-bisphosphate (PI-P2) and phosphatidic acid (PA) induced by ACh, histamine or 5-HT. Thus, the synthesis of inositol 1,4,5-trisphosphate is not affected by stimulation of the P2-adrenoceptor.6 ACh increased the free Ca2" concentration to a greater extent than that produced by histamine or 5-HT. These changes were reduced by procaterol, except for those induced by high concentrations of ACh (over I1LM).7 It is concluded that procaterol relaxes tissues precontracted by various agonists due to a reduction in the free Ca2+. This inhibitory action may be due to an increase in the amount ofcyclic AMP but does not result from an inhibition of the hydrolysis of phosphatidyl inositols. The hyperpolarization induced by procaterol may partly contribute to the observed relaxation.

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Section: Introductionmentioning

confidence: 93%

Relaxing actions of procaterol, a β₂‐adrenoceptor stimulant, on smooth muscle cells of the dog trachea

Fujiwara

Sumimoto

Itoh

et al. 1988

British J Pharmacology

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Effects of indomethacin and prostaglandin E2 on amylase secretion by rat parotid tissue

Hata

Takeuchi

Asano

et al. 1990

Biochemical Pharmacology

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Re-evaluation of the stimulatory effect of norepinephrine on the secretion of amylase in the parotid gland of the rat

Hata

Yagasaki

1989

Neuropharmacology

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Supersensitivity of Amylase Secretion from Rat Parotid Tissue—Its Selective Nature for the β2-Adrenergic Response

Cited by 6 publications

References 11 publications

Relaxing actions of procaterol, a β₂‐adrenoceptor stimulant, on smooth muscle cells of the dog trachea

Relaxing actions of procaterol, a β₂‐adrenoceptor stimulant, on smooth muscle cells of the dog trachea

Effects of indomethacin and prostaglandin E2 on amylase secretion by rat parotid tissue

Re-evaluation of the stimulatory effect of norepinephrine on the secretion of amylase in the parotid gland of the rat

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Supersensitivity of Amylase Secretion from Rat Parotid Tissue—Its Selective Nature for the β2-Adrenergic Response

Cited by 6 publications

References 11 publications

Relaxing actions of procaterol, a β2‐adrenoceptor stimulant, on smooth muscle cells of the dog trachea

Relaxing actions of procaterol, a β2‐adrenoceptor stimulant, on smooth muscle cells of the dog trachea

Effects of indomethacin and prostaglandin E2 on amylase secretion by rat parotid tissue

Re-evaluation of the stimulatory effect of norepinephrine on the secretion of amylase in the parotid gland of the rat

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Relaxing actions of procaterol, a β₂‐adrenoceptor stimulant, on smooth muscle cells of the dog trachea

Relaxing actions of procaterol, a β₂‐adrenoceptor stimulant, on smooth muscle cells of the dog trachea