Supersonic Shear Imaging and Transient Elastography With the XL Probe Accurately Detect Fibrosis in Overweight or Obese Patients With Chronic Liver Disease

Feasibility of transient elastography versus real-time two-dimensional shear wave elastography in difficult-to-scan patients

“…While some studies indicate that the feasibility of 2D-SWE is superior to TE [13,14], others do not. [15][16][17] This study therefore aimed to determine the role of the XL probe and repeated examinations for TE success rate, and to evaluate whether 2D-SWE could achieve reliable results in patients where TE had failed or were unreliable.…”

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“…In these studies the diagnostic performance for 2D-SWE was better than for TE [139,159] and serum fibrosis markers (FIB-4 index, APRI and Forns' index) [159]. In one study including 102 obese CHC patients, 2D-SWE had excellent diagnostic accuracy for the detection of severe fibrosis and cirrhosis (AUROC > 0.90 for both) [91].…”

Asian-Pacific Association for the Study of the Liver (APASL) consensus guidelines on invasive and non-invasive assessment of hepatic fibrosis: a 2016 update

“…The mean ± SD LS as measured by SSI in patients without known liver pathology was found to be 6 ± 1.4, slightly higher in men, and is not affected by BMI [132]. Many studies have shown that SSI and TE using an XL probe accurately quantified liver stiffness and fibrosis stage in obese chronic liver disease patients, including those with chronic HCV infection, compared with histologic analyses and ARFI [133][134][135][136][137]. However, SSI was shown to be a poor predictor of disease activity and steatosis level [136].…”