Originally emerged within the context of string and quantum field theory, and later fruitfully extrapolated to photonics, the algebraic transformations of quantum-mechanical supersymmetry were conceived in the space realm. Here, we introduce a paradigm shift, demonstrating that Maxwell's equations also possess an underlying supersymmetry in the time domain. As a result, we obtain a simple analytic relation between the scattering coefficients of a large variety of time-varying optical systems and uncover a wide new class of reflectionless, three-dimensional, all-dielectric, isotropic, omnidirectional, polarization-independent, non-complex media. Temporal supersymmetry is also shown to arise in dispersive media supporting temporal bound states, which allows engineering their momentum spectra and dispersive properties. These unprecedented features define a promising design platform for free-space and integrated photonics, enabling the creation of a number of novel reconfigurable reflectionless devices, such as frequency-selective, polarization-independent and omnidirectional invisible materials, compact frequency-independent phase shifters, broadband isolators, and versatile pulseshape transformers.