EditorialPeripheral artery disease (PAD) has been associated with specific risk factors such as smoking, diabetes mellitus (DM) as well as previous coronary and cerebrovascular disease [1]. Furthermore, PAD has been correlated to an increased risk for cardiovascular morbidity and mortality [2,3]. Although the most common symptom of PAD is intermittent claudication, recent data reveal that asymptomatic PAD is several times more common in the general population [1]. Therefore, modification of atherosclerosis risk factors as well as exercise therapy are strongly recommended as first-line treatment by recent guidelines [4].Patients with history of PAD experience significant limitation in everyday physical activities and walking, in particular [5,6]. In a recent study of more than 2,000 patients with suspected or known PAD, de Liefde et al have highlighted the prognostic value of impared walking distance on long-term major cardiovascular events [7]. In such patients, measurement of ankle brachial index (ABI) remains a valuable diagnostic and prognostic tool. ABI is an independent risk factor for cardiovascular diseases and mortality, even in asymptomatic patients [8,9]. Finally, there is recent evidence correlating abnormal measurements of ABI (< 0.9 or > 1.4) with silent cerebral small vessel disease [10] and a higher risk for presenting stroke in general population [11].Regarding the effect of physical activity on reducing symptoms and cardiovascular risk in PAD patients, several studies have shown that exercise has a known positive influence on vascular risk factors such as hypertension, hypercholesterolemia, and diabetes mellitus [12]. Furthermore, reports show that patients with PAD (or more specifically, intermittent claudication) who are physically active are less likely to die compared with a group of sedentary patients with PAD [13]. After adjustments for age, ABI, and body mass index, these results are similar in patients with intermittent claudication [13]. Research data clearly indicate that exercise treatment can improve walking distance and therefore, it is recommended in recent guidelines [4]. However, type and duration of exercise remains still under investigation.The most common exercise therapy prescription consists of onetime oral advice to walk more, usually without supervision or followup. However, there is no evidence to support the efficacy of this advice, and compliance is known to be low [14]. Several factors such as fear against pain, inadequate knowledge of the underlying disease, and poor general condition, contribute to the difficulty of starting, sustaining, and maintaining exercise therapy as indicated. Therefore, the importance of supervised exercise therapy (SET) is increasingly recognized. SET includes adequate coaching to increase the maximal walking distance as well as coaching in the necessary lifestyle changes, such as smoking cessation, weight control, and increase in overall exercise. A recent Cochrane Review has identified a significant improvement in walking distance in patie...