2011
DOI: 10.1155/2011/596240
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Supplemental Cellular Protection by a Carotenoid Extends Lifespan via Ins/IGF-1 Signaling inCaenorhabditis elegans

Abstract: Astaxanthin (AX), which is produced by some marine animals, is a type of carotenoid that has antioxidative properties. In this study, we initially examined the effects of AX on the aging of a model organism C. elegans that has the conserved intracellular pathways related to mammalian longevity. The continuous treatments with AX (0.1 to 1 mM) from both the prereproductive and young adult stages extended the mean lifespans by about 16–30% in the wild-type and long-lived mutant age-1 of C. elegans. In contrast, t… Show more

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Cited by 66 publications
(66 citation statements)
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“…The change of SOD-3::gfp expression illustrated that AST extended lifespan of C. elegans potentially by modulating the insulin/insulin-like growth factor (IGF) signalling (IIS) pathway. This is consistent with our previous findings and the results of Yazaki et al (2011).…”
supporting
confidence: 94%
See 1 more Smart Citation
“…The change of SOD-3::gfp expression illustrated that AST extended lifespan of C. elegans potentially by modulating the insulin/insulin-like growth factor (IGF) signalling (IIS) pathway. This is consistent with our previous findings and the results of Yazaki et al (2011).…”
supporting
confidence: 94%
“…A number of antioxidants including coenzyme Q10 (Fischer, Niklowitz, Menke, & Döring, 2014), resveratrol (Regitz, Fitzenberger, Mahn, Dußling, & Wenzel, 2016) and tea polyphenols (Deusing et al, 2015) have been found to extend the lifespan of C. elegans. A recent study has shown that AST could increase the lifespan of C. elegans (Yazaki, Yoshikoshi, Oshiro, & Yanase, 2011), and our recent research also suggested that AST resulted in a lifespan extension via an Ins/IGF-1 signalling pathway during normal ageing of C. elegans (Luo, Liu, Cao, He, & Liu, 2015). In this study, the antioxidation and anti-ageing activities of different stereoisomeric AST were determined by chemicalbased (DPPH, ABTS and ORAC) assays, cellular-based (Caco-2) antioxidant assays, and organism-based (C. elegans) detection.…”
mentioning
confidence: 84%
“…Particularly, Z. Zhang et al found out that the consumption of lutein prolonged the lifespan of D. melanogaster and increased their resistance to paraquat and hydrogen dioxide [39]. K. Yazaki et al prolonged life of wild-type C. elegans and age-1 mutant by another carotenoid astaxanthin [40]. In their study, the decreased mitochondrial production of reactive oxygen species, increased expression of target genes of DAF-16 (a homologue of mammalian transcription factor FOXO) and nuclear localization of the DAF-16 transcription factor were observed.…”
Section: Discussionmentioning
confidence: 99%
“…Because our method is very efficient at delivering hydrophobic antioxidants to nematodes, significant pro-longevity effects were observed at a concentration of 86 lg per mNGM plate, which is a tenfold lower concentration than that used by Adachi and Ishii (2000). Oral administration of astaxanthin (6 lg/10 ml of mNGM plate) and c-tocopherol (43 lg/10 ml of mNGM plate) also prolonged the lifespan at a very low dose compared to previous reports in which 0.1-1 mM (59.7-597 lg/ml) astaxanthin or 200 lg/ml c-tocopherol were added to the medium (Yazaki et al 2011;Zou et al 2007). This delivery mechanism should therefore facilitate clarification of the effects of hydrophobic compounds such as T3 on longevity in future studies.…”
Section: Discussionmentioning
confidence: 73%