Supplemental Effect of Lysine on Growth Depression of Rats Fed Wheat Gluten Diets Containing Excessive Amount of Some Individual Amino Acids

Muramatsu, Keiichiro; Sakurai, Kyosuke

doi:10.3177/jnsv.19.513

Cited by 4 publications

(1 citation statement)

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“…In an early study (9) we observed that the toxic effect of tyrosine, which deve GLUTEN AND TYROSINE TOXICITY 121 Table 5. Effect of supplementation of limiting amino acids on urinary excretion of total phenols, tyrosine metabolites and free tyrosine in rats fed the 10% wheat gluten diets containing excess tyrosine.…”

Section: Discussionmentioning

confidence: 99%

Effect of supplementation of limiting amino acids on tyrosine toxicity in rats fed wheat gluten diets.

Yamamoto

Orita

Muramatsu

1977

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe effect of supplementation of limiting amino acids on rats fed a 10 or 20% wheat gluten diet containing 5% tyrosine has been investigated. Growth-limiting amino acids in a 20% wheat gluten diet were lysine and threonine. When rats were fed a 20% wheat gluten diet containing excess tyrosine, the addition of 1.0% lysine• HC1 or 1.0% lysine• HC1 and 0.4% threonine completely prevented the development of tyrosine toxicity, and was accompanied by a lowering of free tyrosine concentrations in plasma, liver and muscle. In rats receiving a 10 % wheat gluten diet, lysine, threonine and methionine were limiting for growth. The addition of 1.0% lysine• HC1 to the 10% wheat gluten plus 5 tyrosine diet failed to alleviate the tyrosine toxicity, but the supplement of 1.0% lysine• HC1 and 0.4% threonine could partially alleviate the toxicity. The combined addition of 1.0% lysine• HC1, 0.4% threonine and 0.5% methionine was most effective. The free tyrosine concen trations in plasma, liver and muscle were lowered greatly by the supple mentation of three limiting amino acids, but amounts of free tyrosine and phenolic metabolites excreted in the urine did not decrease with ad dition of these limiting amino acids.It has been shown in young rats fed a low protein diet containing excess tyrosine, that the growth is retarded and eye and paw lesions develop (1-6). Recently we found that the growth depression and appearance of pathological lesions which developed in rats fed a 10% casein diet containing 5% tyrosine were alleviated by the supplement of methionine and threonine, the first and second limiting amino acids respectively, in the diet (7,8).On the other hand, it was also demonstrated in our laboratory (9) that the tyrosine toxicity produced by feeding an 11.6% wheat gluten diet containing 5 tyrosine (equivalent in N content to 10% casein) was not at all alleviated by the 115

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Section: Discussionmentioning

confidence: 99%