Supplemental essential amino acids augment the somatomedin-C/insulin-like growth factor I response to refeeding after fasting

Clemmons, David R.; Seek, Melvin; Underwood, Louis E.

doi:10.1016/0026-0495(85)90230-6

Cited by 100 publications

(38 citation statements)

References 22 publications

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“…Vegan men and women (who consume no dairy or other animal products) have significantly lower serum IGF-I levels than both lacto-ovo vegetarians and meat eaters (Allen et al, 2000(Allen et al, , 2002, which may be due to their lower intake of essential amino acids (Allen et al, 2002). Intervention studies have also shown that protein restriction can lower IGF-I levels in both animals (Miura et al, 1992;Takenaka et al, 2000;Katsumata et al, 2002) and humans (Smith et al, 1995), and that the increases in IGF-I levels following re-feeding are strongly related to the essential amino-acid component of the diet (Clemmons et al, 1985). The effects of protein and especially dairy protein on IGF-I could be important, because high serum IGF-I levels have been associated with a moderately increased risk of prostate cancer in several large-scale prospective studies including EPIC (Renehan et al, 2004;Allen et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Animal foods, protein, calcium and prostate cancer risk: the European Prospective Investigation into Cancer and Nutrition

et al. 2008

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We examined consumption of animal foods, protein and calcium in relation to risk of prostate cancer among 142 251 men in the European Prospective Investigation into Cancer and Nutrition. Associations were examined using Cox regression, stratified by recruitment centre and adjusted for height, weight, education, marital status and energy intake. After an average of 8.7 years of follow-up, there were 2727 incident cases of prostate cancer, of which 1131 were known to be localised and 541 advanced-stage disease. A high intake of dairy protein was associated with an increased risk, with a hazard ratio for the top versus the bottom fifth of intake of 1.22 (95% confidence interval (CI): 1.07 -1.41, P trend ¼ 0.02). After calibration to allow for measurement error, we estimated that a 35-g day À1 increase in consumption of dairy protein was associated with an increase in the risk of prostate cancer of 32% (95% CI: 1 -72%, P trend ¼ 0.04). Calcium from dairy products was also positively associated with risk, but not calcium from other foods. The results support the hypothesis that a high intake of protein or calcium from dairy products may increase the risk for prostate cancer.

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Section: Discussionmentioning

confidence: 99%

Animal foods, protein, calcium and prostate cancer risk: the European Prospective Investigation into Cancer and Nutrition

et al. 2008

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“…In man, serum Sm-C/IGF I is reduced dramatically by fasting and returns to normal with refeeding (6). The rate of return of serum Sm-C/ IGF I concentrations from low basal fasting levels to normal is dependent on the quality of the diet which is refed (7)(8)(9).…”

Section: Discussionmentioning

confidence: 99%

Tissue and Serum Concentrations of Somatomedin-C/Insulin-Like Growth Factor I in Fetal Rats Made Growth Retarded by Uterine Artery Ligation

Vileisis

D’Ercole

1986

Pediatr Res

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“…The association between PI and growth is possibly mediated through IGF-I. Dietary depletion has a marked negative effect on IGF-I concentrations (Isley et al, 1983(Isley et al, , 1984Clemmons et al, 1985) in adults, and in malnourished children who have low concentrations of IGF-I, there is a quick and marked increase in IGF-I during rehabilitation (Smith et al, 1989). There is some evidence suggesting that protein restriction will result in decreased IGF-I concentrations in healthy children (Smith et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

High intakes of skimmed milk, but not meat, increase serum IGF-I and IGFBP-3 in eight-year-old boys

Hoppe¹,

Mølgaard²,

et al. 2004

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Objective: To examine whether a high protein intake (PI) from either milk or meat, at a level often seen in late infancy, could increase s-IGF-I and s-IGF-I/s-IGFBP-3 in healthy, prepubertal children. IGF-I levels are positively associated with growth velocity in children and some studies suggest that a high animal PI can stimulate growth. During protein deprivation IGF-I decrease, but it is unknown whether a high PI can increase s-IGF-I in well-nourished children. Design: In all, 24 8-y-old boys were asked to take either 1.5 l of skimmed milk (n ¼ 12) or the same amount of protein as 250 g low fat meat (n ¼ 12) daily for 7 days. The remaining diet they could choose freely. At baseline and after 7 days, anthropometrical variables were measured, diet was registered (3-day weighed records), and s-IGF-I and s-IGFBP-3 (RIA) were determined after fast. Results: PI increased by 61% in the milk group to 4.0 g/kg/day (Po0.0001) and by 54% in the meat group to 3.8 g/kg/day (P ¼ 0.001). The high milk intake increased s-IGF-I by 19% (P ¼ 0.001) and s-IGF-I/s-IGFBP-3 by 13% (Po0.0001). There were no increases in the meat group. Conclusions: High intake of milk and not meat, increased concentrations of s-IGF-I and s-IGF-I/s-IGFBP-3 significantly. Compounds in milk and not a high PI as such seem to stimulate IGF-I. This might explain the positive effect of milk intake on growth seen in some studies.

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Supplemental essential amino acids augment the somatomedin-C/insulin-like growth factor I response to refeeding after fasting

Cited by 100 publications

References 22 publications

Animal foods, protein, calcium and prostate cancer risk: the European Prospective Investigation into Cancer and Nutrition

Animal foods, protein, calcium and prostate cancer risk: the European Prospective Investigation into Cancer and Nutrition

Tissue and Serum Concentrations of Somatomedin-C/Insulin-Like Growth Factor I in Fetal Rats Made Growth Retarded by Uterine Artery Ligation

High intakes of skimmed milk, but not meat, increase serum IGF-I and IGFBP-3 in eight-year-old boys

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