Supplemental feeding of phospholipid-enriched alkyl phospholipid from krill relieves spontaneous atopic dermatitis and strengthens skin intercellular lipid barriers in NC/Nga mice

Watanabe, Nana; Suzuki, Takuya; Yamazaki, Yuya; Sugiyama, Kozue; Koike, Seiji; Nishimukai, Megumi

doi:10.1080/09168451.2018.1559024

Cited by 15 publications

(12 citation statements)

References 32 publications

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“…Additionally, a mouse model for atopic dermatitis (AD) was found to have increased levels of alkyl‐phospholipids while ceramides in the skin barrier were decreased. Interestingly, supplemental feeding of ether lipids could both restore ceramide levels and alleviate skin inflammation, pointing out how the levels of a specific lipid can be modulated by altering other lipid classes . In these lines, patients with Sjögren‐Larsson syndrome seem to have cutaneous and neurological symptoms which are thought to be a result of altered levels of ether phospholipids and sphingolipids .…”

Section: Crosstalk Of Ether Lipids With Other Lipid Classesmentioning

confidence: 99%

On the road to unraveling the molecular functions of ether lipids

Jiménez‐Rojo

Riezman

2019

FEBS Letters

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Ether lipids are glycerolipids further classified into alkyl‐ether and alkenyl‐ether (also termed plasmalogens) lipids. The two ether lipid subclasses share the first steps of their synthesis. However, alkyl‐ether and alkenyl‐ether lipids differ in their structure and physico‐chemical properties (featuring different head groups) and, thus, probably in their functions. Ether lipids have intermittent distribution across the evolutionary tree and defects in their synthesis have been shown to perturb cellular homeostasis and lead to disease in humans. Here, we review their structure, their interactions with other lipids, and their potential roles in cellular functions, such as membrane homeostasis and membrane trafficking. Moreover, we discuss still unclear aspects of these lipids such as their subcellular distribution, and the need to unravel their molecular functions as well as how novel tools to study lipid biology will help clarify these aspects.

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Section: Crosstalk Of Ether Lipids With Other Lipid Classesmentioning

confidence: 99%

On the road to unraveling the molecular functions of ether lipids

Jiménez‐Rojo

Riezman

2019

FEBS Letters

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“…The functions of ether PLs in mammalian cells are still largely unknown, although there is increasing awareness of their importance in the regulation of membrane homeostasis and in cell signaling [27]. For instance, in a mouse model of atopic dermatitis, ceramide levels were decreased in the skin barrier, while supplemental feeding with ether lipids helped to alleviate skin inflammation [28]. Moreover, plasmalogens may function as endogenous antioxidants by protecting unsaturated membrane lipids from oxidation and scavenging reactive oxygen species (ROS) [29].…”

Section: Discussionmentioning

confidence: 99%

Differential Modulation of the Phospholipidome of Proinflammatory Human Macrophages by the Flavonoids Quercetin, Naringin and Naringenin

et al. 2020

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The immunomodulatory activity of flavonoids is increasingly appreciated. Macrophage phospholipids (PLs) play crucial roles in cell-mediated inflammatory responses. However, little is known on how these PLs are affected upon flavonoid treatment. In this work, we have used mass-spectrometry-based lipidomics to characterize the changes in the phospholipidome of proinflammatory human-macrophage-like cells (THP-1-derived and LPS+IFN-γ-stimulated) incubated with non-cytotoxic concentrations of three flavonoids: quercetin, naringin and naringenin. One hundred forty-seven PL species belonging to various classes were identified, and their relative abundances were determined. Each flavonoid displayed its own unique signature of induced effects. Quercetin produced the strongest impact, acting both on constitutive PLs (phosphatidylcholines, phosphatidylethanolamines and sphingomyelins) and on minor signaling lipids, such as phosphatidylinositol (PI) and phosphatidylserine (PS) species. Conversely, naringin hardly affected structural PLs, producing changes in signaling molecules that were opposite to those seen in quercetin-treated macrophages. In turn, albeit sharing some effects with quercetin, naringenin did not change PI and PS levels and interfered with a set of phosphatidylcholines distinct from those modulated by quercetin. These results demonstrate that flavonoids bioactivity involves profound and specific remodeling of macrophage phospholipidome, paving the way to future studies on the role of cellular phospholipids in flavonoid-mediated immunomodulatory effects.

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“…In agreement with our results, changes in phospholipids were reported to be present in the serum of atopic patients compared with controls [ 57 ]. In another mouse model of AD, NC/Nga mice, phospholipids were decreased in plasma, and oral supplementation of plasmalogens increased the phospholipid concentration in the skin of the mice and improved the skin condition [ 58 ]. In human skin, one study reported an increase of phospholipid content in AD patients compared to healthy subjects [ 24 ], while others showed a global change in phospholipids with an increase in the presence of shorter acylated fatty acids [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Lipidomic Profiling of the Epidermis in a Mouse Model of Dermatitis Reveals Sexual Dimorphism and Changes in Lipid Composition before the Onset of Clinical Disease

et al. 2020

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Atopic dermatitis (AD) is a multifactorial disease associated with alterations in lipid composition and organization in the epidermis. Multiple variants of AD exist with different outcomes in response to therapies. The evaluation of disease progression and response to treatment are observational assessments with poor inter-observer agreement highlighting the need for molecular markers. SHARPIN-deficient mice (Sharpincpdm) spontaneously develop chronic proliferative dermatitis with features similar to AD in humans. To study the changes in the epidermal lipid-content during disease progression, we tested 72 epidermis samples from three groups (5-, 7-, and 10-weeks old) of cpdm mice and their WT littermates. An agnostic mass-spectrometry strategy for biomarker discovery termed multiple-reaction monitoring (MRM)-profiling was used to detect and monitor 1,030 lipid ions present in the epidermis samples. In order to select the most relevant ions, we utilized a two-tiered filter/wrapper feature-selection strategy. Lipid categories were compressed, and an elastic-net classifier was used to rank and identify the most predictive lipid categories for sex, phenotype, and disease stages of cpdm mice. The model accurately classified the samples based on phospholipids, cholesteryl esters, acylcarnitines, and sphingolipids, demonstrating that disease progression cannot be defined by one single lipid or lipid category.

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Supplemental feeding of phospholipid-enriched alkyl phospholipid from krill relieves spontaneous atopic dermatitis and strengthens skin intercellular lipid barriers in NC/Nga mice

Cited by 15 publications

References 32 publications

On the road to unraveling the molecular functions of ether lipids

On the road to unraveling the molecular functions of ether lipids

Differential Modulation of the Phospholipidome of Proinflammatory Human Macrophages by the Flavonoids Quercetin, Naringin and Naringenin

Lipidomic Profiling of the Epidermis in a Mouse Model of Dermatitis Reveals Sexual Dimorphism and Changes in Lipid Composition before the Onset of Clinical Disease

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