Supplemental home parenteral nutrition improved nutrition status with comparable quality of life in malnourished unresectable/metastatic gastric cancer receiving salvage chemotherapy

Ma, Cheng‐Jen; Huang, Ching‐Wen; Yeh, Yung‐Sung; Tsai, Hsiang‐Lin; Su, Wei‐Chih; Chang, Tsung‐Kun; Sun, Lulu; Shih, Yuh-Chuan; Yu, Fang‐Jung; Wu, Deng‐Chyang; Wang, Jaw‐Yuan

doi:10.1007/s00520-020-05687-4

Cited by 12 publications

(33 citation statements)

References 27 publications

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“…An observational prospective study with a small patient sample observed that sHPN, administered even for only 1 or 2 months, is positively associated with improved QoL and nutritional status in GC patients with compromised enteral intake and malnutrition [ 111 ].…”

Section: Nutritional Support Strategiesmentioning

confidence: 99%

Nutritional Support Indications in Gastroesophageal Cancer Patients: From Perioperative to Palliative Systemic Therapy. A Comprehensive Review of the Last Decade

et al. 2021

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Gastric cancer treatments are rapidly evolving, leading to significant survival benefit. Recent evidence provided by clinical trials strongly encouraged the use of perioperative chemotherapy as standard treatment for the localized disease, whereas in the advanced disease setting, molecular characterization has improved patients’ selection for tailored therapeutic approaches, including molecular targeted therapy and immunotherapy. The role of nutritional therapy is widely recognized, with oncologic treatment’s tolerance and response being better in well-nourished patients. In this review, literature data on strategies or nutritional interventions will be critically examined, with particular regard to different treatment phases (perioperative, metastatic, and palliative settings), with the aim to draw practical indications for an adequate nutritional support of gastric cancer patients and provide an insight on future directions in nutritional strategies. We extensively analyzed the last 10 years of literature, in order to provide evidence that may fit current clinical practice both in terms of nutritional interventions and oncological treatment. Overall, 137 works were selected: 34 Randomized Clinical Trials (RCTs), 12 meta-analysis, 9 reviews, and the most relevant prospective, retrospective and cross-sectional studies in this setting. Eleven ongoing trials have been selected from clinicaltrial.gov as representative of current research. One limitation of our work lies in the heterogeneity of the described studies, in terms of sample size, study procedures, and both nutritional and clinical outcomes. Indeed, to date, there are no specific evidence-based guidelines in this fields, therefore we proposed a clinical algorithm with the aim to indicate an appropriate nutritional strategy for gastric cancer patients.

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Section: Nutritional Support Strategiesmentioning

confidence: 99%

Nutritional Support Indications in Gastroesophageal Cancer Patients: From Perioperative to Palliative Systemic Therapy. A Comprehensive Review of the Last Decade

et al. 2021

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“…Na amostra, 13 estudos abordaram intervenções nutricionais adotadas na promoção da qualidade de vida 12,14,32,34,35,16,18,20,[22][23][24][25]29 . As mais frequentes incluíram o aconselhamento nutricional, o uso de suplementação nutricional oral e o suporte nutricional parenteral domiciliar 14,18,20,25,29,32,34,35 , encontrando-se benefícios no uso dessas intervenções.…”

Section: Intervenções E Efeitos Encontrados Na Qualidade De Vidaunclassified

“…A NPT domiciliar está associada à melhor QV em pacientes com câncer, porém, há necessidade de um ECR 20 . NPT domiciliar teve um impacto positivo no EN e na QV em pacientes com desnutrição e câncer gástrico em quimioterapia logo após o início do tratamento 29 . NPT domiciliar em pacientes com câncer promoveu uma melhora geral na QV, principalmente no componente físico 34 .…”

Section: Npt / Npt Domiciliarunclassified

“…Intervenções e efeitos encontrados no estado nutricional D e z e s s e t e e st u d o s t r a b a l h a r a m a s inter venções para a melhoria do estado nutricional 13,14,28,29,[31][32][33][34][35]15,17,20,21,[23][24][25]27 . Cinco deles observaram a melhora no estado nutricional com a intervenção de aconselhamento nutricional 13,21,25,32,35 .…”

Section: Pequenas Quantidades De Líquidos E Alimentosunclassified

“…A nutrição artificial e sua eficácia no estado nutricional de pacientes paliativos foi abordada em sete dos estudos selecionados 17,20,[27][28][29]33,34 . Foi observado que quando foi possível ingerir uma dieta regular complementada com suplemento oligomérico, a albumina sérica foi melhor preservada 17 .…”

Section: Pequenas Quantidades De Líquidos E Alimentosunclassified

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Intervenções nutricionais para idosos em cuidados paliativos: uma revisão de escopo

Moura

Barbosa

Gonçalves

et al. 2021

Rev. bras. geriatr. gerontol.

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Resumo Objetivo Analisar as intervenções nutricionais adotadas em pessoas idosas em cuidados paliativos encontradas na literatura. Método Trata-se de uma revisão de escopo, cuja busca foi realizada nas seguintes bases de dados: PubMed, LILACS, CINAHL, Scopus, Web of Science, EMBASE e na literatura cinzenta por meio do Google Scholar, OpenGrey e ProQuest Dissertations & Theses Global, sem restrição temporal e de idioma. Foram realizadas as buscas utilizando-se os descritores e palavras-chave que foram combinados por meio de operadores booleanos AND e OR: “Nutritional Intervention”, “Intervenção Nutricional”, “Palliative Care”, “Cuidados Paliativos”, “Aged” e “Idosos”. Resultados Dos 5.942 estudos encontrados, 13 estudos foram selecionados. Pela estratégia de busca reversa foram identificados 13 estudos adicionais, originando um resultado final de 26 estudos. As intervenções nutricionais adotadas em pessoas idosas em cuidados paliativos compreendem em sua maioria: aconselhamento nutricional, suplementação nutricional oral e a nutrição artificial por meio de nutrição enteral e parenteral. Essas intervenções estão voltadas à qualidade de vida, ao manejo de sintomas e ao estado nutricional. Conclusão Embora haja lacunas na literatura quanto às intervenções nutricionais voltadas para idosos em cuidados paliativos, fica evidenciada a importância da atuação do nutricionista para promoção da qualidade de vida e alívio do sofrimento dessa população.

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Impact of malnutrition and nutritional support after gastrectomy in patients with gastric cancer

Kang,

Lee

2024

Annals of Gastroent Surgery

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Malnutrition, characterized by altered body composition and impaired function, is particularly prevalent among gastric cancer patients, affecting up to 60% of them. Malnutrition in these patients can manifest both before and after surgery, due to factors such as gastric outlet obstruction, cancer cachexia, and anatomical changes. Notably, total gastrectomy (TG) presents the most significant nutritional challenges. However, function‐preserving gastrectomy, such as pylorus‐preserving gastrectomy (PPG) and proximal gastrectomy (PG), have shown promise in improving nutritional outcomes. Effective nutritional risk screening and assessment are vital for identifying patients at risk. Nutritional support not only improves nutritional parameters but also reduces complications, enhances quality of life (QoL) and survival rates. Those unable to maintain more than 50% of the recommended intake for over 7 days are recommended for nutritional support. Common methods of nutritional support include oral nutrition supplements (ONS), enteral nutrition (EN), or parenteral nutrition (PN) depending on the patient's status. Effect of perioperative nutritional support remains controversial. Preoperative interventions including ONS and PN have shown mixed results, with selective benefits in patients with sarcopenia or hypoalbuminaemia, while impact of EN in gastric outlet obstruction patients have been positive. In contrast postoperative support appears to be consistent. Tube feeding after TG has shown improvements, and ONS have been effective in reducing weight loss and improving nutritional biomarkers. PN was also associated with benefits such as weight maintenance and QoL. This review explores the mechanisms, assessment, and clinical impact of malnutrition, emphasizing the importance of nutritional support in gastric cancer patients undergoing gastrectomy.

show abstract

Supplemental home parenteral nutrition improved nutrition status with comparable quality of life in malnourished unresectable/metastatic gastric cancer receiving salvage chemotherapy

Cited by 12 publications

References 27 publications

Nutritional Support Indications in Gastroesophageal Cancer Patients: From Perioperative to Palliative Systemic Therapy. A Comprehensive Review of the Last Decade

Nutritional Support Indications in Gastroesophageal Cancer Patients: From Perioperative to Palliative Systemic Therapy. A Comprehensive Review of the Last Decade

Intervenções nutricionais para idosos em cuidados paliativos: uma revisão de escopo

Impact of malnutrition and nutritional support after gastrectomy in patients with gastric cancer

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