2023
DOI: 10.1158/1541-7786.22525926.v1
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Supplementary Figures 1-7 & Supplementary Tables 1-4 from Transcriptomic Analysis of Diffuse Intrinsic Pontine Glioma (DIPG) Identifies a Targetable ALDH-Positive Subset of Highly Tumorigenic Cancer Stem-like Cells

Abstract: <p>Supplemental Figure S1. FACS analysis of Aldefluor stained SU-DIPG XIII cells. Supplemental Figure S2: Downstream signaling changes by inhibition of MAPK and PI3K/mTOR in DIPG cells. Supplemental Figure S3. Bru-sequencing transcriptome analysis identifies gene sets regulated by MAPK and PI3K/mTOR inhibition in ALDH positive SU-DIPG XIII cells. Supplemental Figure S4. A-C. Heatmaps of Bru-seq RPKM values in single agent treated (901 or GSK) ALDH+ SU-DIPG XII cells highlight treatment effects on "stemne… Show more

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