Supplementary Figures from Lipocalin-2 Promotes Pancreatic Ductal Adenocarcinoma by Regulating Inflammation in the Tumor Microenvironment

Abstract

<p>Figure S1. LCN2 plasma levels do not correlated with BMI of patients with metastatic PDAC. Figure S2. Lcn2 and SLC22A17 expression in SVF from mice. Figure S3. Lcn2 expression is depleted in Lcn2-/-/KRasG12D/CRE animals and experience lower changes in body weight and effects of caerulein treatments in mice with and without Lcn2 expression. Figure S4. KPC-LUC cells expressed higher levels of Lcn2 compared to normal pancreas from wild type mice. Figure S5. KPC-LUC cells injected in the pancreas do not survive in all Lcn2-/- mice. Figure S6. Lcn2 depletion attenuates ECM remodeling, immune infiltration and tumor cell proliferation in Lcn2 null mice with tumors and invasion of peritoneal macrophages was not impaired in Lcn2 null mice. Figure S7. Lcn2 null mice expressed lower levels of the Lcn2 receptor SLC22A17. Figure S8. LCN2 induces a pro-inflammatory response in PSCs that is reduced after downregulation of the SLC22A17 receptor. Figure S9. SLC22A17 expression in adipose tissue from mice.</p>