Supplementation for Nutritional Anemias

Ekström, Eva‐Charlotte

doi:10.1201/9781420036787.ch8

Cited by 8 publications

(6 citation statements)

References 40 publications

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“…Most would agree that the ultimate aim of iron supplementation is to reduce the negative health or developmental consequences of iron deficiency (7). Iron supplementation during pregnancy is often considered to be a controversial activity as there is no conclusive evidence of its functional effect beyond iron and hematological status (43–45).…”

Section: Discussionmentioning

confidence: 99%

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Iron supplementation during pregnancy in Sweden: to what extent is the national recommendation followed?

Wulff

Ekström

2003

Acta Obstet Gynecol Scand

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Section: Discussionmentioning

confidence: 99%

“…While most low income countries have followed recommendations endorsed by WHO (6), the recommendations adopted by high-income countries have been less homogenous (7). Even within Scandinavia with similar maternal anemia prevalence different approaches and doses have been recommended.…”

mentioning

confidence: 99%

Iron supplementation during pregnancy in Sweden: to what extent is the national recommendation followed?

Wulff

Ekström

2003

Acta Obstet Gynecol Scand

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“…Effectiveness is affected both by efficacy and by compliance. Thus, in contrast to efficacy, which is affected only by biology, effectiveness is influenced by both behavioral and biological factors (18). It is useful to address both efficacy and effectiveness because biologically and behaviorally induced limitations call for different actions.…”

Section: Analytic Approach and Statistical Methodsmentioning

confidence: 99%

Efficacy and trial effectiveness of weekly and daily iron supplementation among pregnant women in rural Bangladesh: disentangling the issues

Ekström

Hyder

Chowdhury

et al. 2002

The American Journal of Clinical Nutrition

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“…Little progress has been made in reducing the prevalence of LBW despite several decades of program implementation that includes routine daily supplementation of pregnant women with iron folic acid (IFA) through the primary health care system [4,5]. Reasons for low effectiveness include inadequacy of delivery systems, side effects and poor compliance among pregnant women [6]. In many parts of South and South East Asia where LBW is high, ~30% of non-pregnant women and 60% of pregnant women are anemic [3], primarily due to iron deficiency, which has been associated with poor birth outcomes [5,7-11].…”

Section: Introductionmentioning

confidence: 99%

Rationale, design, methodology and sample characteristics for the Vietnam pre-conceptual micronutrient supplementation trial (PRECONCEPT): a randomized controlled study

et al. 2012

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BackgroundLow birth weight and maternal anemia remain intractable problems in many developing countries. The adequacy of the current strategy of providing iron-folic acid (IFA) supplements only during pregnancy has been questioned given many women enter pregnancy with poor iron stores, the substantial micronutrient demand by maternal and fetal tissues, and programmatic issues related to timing and coverage of prenatal care. Weekly IFA supplementation for women of reproductive age (WRA) improves iron status and reduces the burden of anemia in the short term, but few studies have evaluated subsequent pregnancy and birth outcomes.The Preconcept trial aims to determine whether pre-pregnancy weekly IFA or multiple micronutrient (MM) supplementation will improve birth outcomes and maternal and infant iron status compared to the current practice of prenatal IFA supplementation only. This paper provides an overview of study design, methodology and sample characteristics from baseline survey data and key lessons learned.Methods/designWe have recruited 5011 WRA in a double-blind stratified randomized controlled trial in rural Vietnam and randomly assigned them to receive weekly supplements containing either: 1) 2800 μg folic acid 2) 60 mg iron and 2800 μg folic acid or 3) MM. Women who become pregnant receive daily IFA, and are being followed through pregnancy, delivery, and up to three months post-partum. Study outcomes include birth outcomes and maternal and infant iron status. Data are being collected on household characteristics, maternal diet and mental health, anthropometry, infant feeding practices, morbidity and compliance.DiscussionThe study is timely and responds to the WHO Global Expert Consultation which identified the need to evaluate the long term benefits of weekly IFA and MM supplementation in WRA. Findings will generate new information to help guide policy and programs designed to reduce the burden of anemia in women and children and improve maternal and child health outcomes in resource poor settings.Trial registrationNCT01665378

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Supplementation for Nutritional Anemias

Cited by 8 publications

References 40 publications

Iron supplementation during pregnancy in Sweden: to what extent is the national recommendation followed?

Iron supplementation during pregnancy in Sweden: to what extent is the national recommendation followed?

Efficacy and trial effectiveness of weekly and daily iron supplementation among pregnant women in rural Bangladesh: disentangling the issues

Rationale, design, methodology and sample characteristics for the Vietnam pre-conceptual micronutrient supplementation trial (PRECONCEPT): a randomized controlled study

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