Supplementation of coenzyme Q10 and α-tocopherol lowers glycated hemoglobin level and lipid peroxidation in pancreas of diabetic rats

Sena, Cristina M.; Nunes, Elsa; Gomes, Ana L.; Santos, Maria S.; Proença, Teresa; Martins, Maria Isabel Morgan; Seiça, Raquel

doi:10.1016/j.nutres.2007.12.005

Cited by 54 publications

(52 citation statements)

References 56 publications

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“…Supplementation of CoQ10 in diet is reported to help maintain a favorable antioxidant/pro-oxidant balance (Sohal and Forster, 2007). Recently, it has been also reported that CoQ10 significantly decreases the level of lipid peroxidation in vivo and in vitro (Sawicka and Dlugosz, 2008;Sena et al, 2008). This effect of CoQ10 may be related to its antioxidant activity since it significantly decreased ROS generation in silica-stimulated RAW 264.7 cells.…”

Section: Discussionmentioning

confidence: 97%

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Antioxidant Effect of CoQ10 on N-nitrosodiethylamine-induced Oxidative Stress in Mice

Song

Kim

Park

et al. 2009

Korean J Physiol Pharmacol

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The antioxidant effect of CoQ10 on N-nitrosodiethylamine (NDEA)-induced oxidative stress was investigated in mice. Food intake and body weight were similar in both CoQ10 and control groups during the 3-week experimental period. NDEA significantly increased the activities of typical marker enzymes of liver function (AST, ALT and ALP) both in control and CoQ10 groups. However, the increase of plasma aminotransferase activity was significantly reduced in the CoQ10 group. Lipid peroxidation in various tissues, such as heart, lung, liver, kidney, spleen and plasma, was significantly increased by NDEA, but this increase was significantly reduced by 100 mg/kg of CoQ10. Superoxide dismutase activity increased significantly upon NDEA-induced oxidative stress in both the control and CoQ10 groups with the effect being less in the CoQ10 group. Catalase activity decreased significantly in both the control and CoQ10 groups treated with NDEA, again with the effect being less in the CoQ10 group. The lesser effect on superoxide dismutase and catalase in the NDEA-treated CoQ10 group is indicative of the protective effect CoQ10. Thus, CoQ10 can offer useful protection against NDEA-induced oxidative stress.

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Section: Discussionmentioning

confidence: 97%

“…Results were expressed as μg/mg protein. Protein concentration was measured by the bicinchoninic acid (BCA) method to correct for differences between preparations (Smith et al, 1987).…”

Section: Easurement Of Lipid Peroxidationmentioning

confidence: 99%

Antioxidant Effect of CoQ10 on N-nitrosodiethylamine-induced Oxidative Stress in Mice

Song

Kim

Park

et al. 2009

Korean J Physiol Pharmacol

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“…Exenatide is an injectable antihyperglycemic drug that works similarly to incretins, or gastrointestinal hormones, such as gastric inhibitory polypeptide, that stimulate insulin release from the pancreas. Exenatide has a longer duration of action than incretins produced by the body because it is less susceptible to degradation by an enzyme called dipeptidyl peptidase-4 (DPP-4) (Sena, Nunes et al 2008). A drug called sitagliptin specifically inhibits DPP-4, thereby increasing levels of naturally produced incretins.…”

Section: Therapeutic Interventionsmentioning

confidence: 99%

Immunologic and Genetic Factors in Type 1 Diabetes Mellitus

Massoud¹,

Massoud²

2012

Autoimmune Diseases - Contributing Factors, Specific Cases of Autoimmune Diseases, and Stem Cell and Other Therapies

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“…6,7,12,13 It could also increase insulin production and secretion probably by stimulating ATP generation in pancreatic beta cells.…”

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confidence: 99%

“…11 This antioxidant has been shown to reduce HbA1C levels in experimental and clinical studies and to improve long term glycemic control. 6,7,12,13 It could also increase insulin production and secretion probably by stimulating ATP generation in pancreatic beta cells.…”

mentioning

confidence: 99%

Coenzyme Q10, Glucose Homeostasis and the Probable Mediating Role of Adipokines

Hosseinzadeh‐Attar

Alipoor

Mehrdadi³

2016

Obes Res Open J

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Coenzyme Q10 is one of the most popular nutritional supplements, which has been discovered in 1955. It is also known as ubiquinone, Q10, CoQ and vitamin Q10. This coenzyme has two isoforms; the oxidized form, ubiquinone, is an electron carrier in mitochondrial respiratory chain and the reduced form, ubiquinol, acts as an antioxidant.1,2 Studies reported its beneficial effects in some diseases such as diabetes, heart failure, hypertension, and Parkinson disease. 3,4 Q10 has also been proposed to be helpful in prevention and treatment of neurodegenerative and mitochondrial related diseases.5 Q10 could potentially be effective on metabolic disorders including lipid profile, blood pressure, glycemic control and insulin resistance in different diseases. [6][7][8] Many diseases are accompanied with imapired glycemic control and insulin resistance.9 Phosphorylation of Insulin Receptor Substrates (IRS) is crucial for insulin signalling cascade, which in turn activates the mitogen-activated protein kinase (MAP-Kinase) with major mitogenic effects and phosphatidylinositol-3-Kinase (PI-3K) with prominent metabolic properties including appropriate cellular glucose distribution.10 Coenzyme Q10 might induce the tyrosine kinase and phosphatidylinositol 3 kinase (PI3k) activity in liver. These enzymes are involved in improving insulin cascade and increasing GLUT2 and tyrosine phosphorylation of IRS-1, which could in turn enhance glucose uptake and inhibit gluconeogenesis in liver. 11This antioxidant has been shown to reduce HbA1C levels in experimental and clinical studies and to improve long term glycemic control. 6,7,12,13 It could also increase insulin production and secretion probably by stimulating ATP generation in pancreatic beta cells.14 Other proposed mechanisms include regulation of insulin receptors, glucose transporters, lipid profile, redox system, and receptors of advanced glycated end products. 15 Obesity, the major growing health problem worldwide, is one the most important contributors of initiation and progression of insulin resistance. 16 The potential mechanisms include higher production of fatty acids, activation of Toll-like receptor 4 and the innate immune system, alterations in endocrine and inflammatory mediators and activation of nuclear factor-κB (NF-κB). 17Recently the metabolic functions of adipose derived peptides, adipokines, have been investigated progressively in different disorders. The changes in the secretion of adipokines in obesity could inhibit insulin signalling through increasing inflammatory adipocytokines and other mediators interfering the IRS phosphorylation and integrity. 17 The relationship between the major adipokines, leptin, adiponectin, resistin and visfatin with glucose homeostasis has previously been demonstrated. 18,19 Leptin could contribute to glucose homeostasis through direct and indirect actions on peripheral tissues. Direct leptin actions might inhibit insulin and glucagon secretion from pancreatic cells. Moreover, leptin could potentially affect insulin signaling in a...

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Supplementation of coenzyme Q10 and α-tocopherol lowers glycated hemoglobin level and lipid peroxidation in pancreas of diabetic rats

Cited by 54 publications

References 56 publications

Antioxidant Effect of CoQ10 on N-nitrosodiethylamine-induced Oxidative Stress in Mice

Antioxidant Effect of CoQ10 on N-nitrosodiethylamine-induced Oxidative Stress in Mice

Immunologic and Genetic Factors in Type 1 Diabetes Mellitus

Coenzyme Q10, Glucose Homeostasis and the Probable Mediating Role of Adipokines

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