Supplementation of Micronutrients against COVID-19

Unnithan, Ajaya Kumar Ayyappan

doi:10.26502/acbr.50170221

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…In this study, IgG response in BALB/c mice was determined serologically using indirect ELISA and the observed higher mean OD 450nm values for selenium-supplemented against the non-supplemented groups over the 28-day immunization period support the report that selenium does boost production of anti-spike IgG antibody [ 24 ]. However, another study found no correlation between selenium status or intake, and SARS-CoV-2 anti-spike IgG antibody response [ 16 ].…”

Section: Discussionsupporting

confidence: 79%

Preliminary In Vivo Evidence of Oral Selenium Supplementation as a Potentiating Agent on a Vector-Based COVID-19 Vaccine in BALB/c Mice

Mudenda¹,

Kimani

Kinyua

et al. 2022

Vaccines

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Evidence of efficacy and toxicity of oral selenium supplementation in vaccine administration against severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in mice models is scarce. In this study, 4 × 109 virus particles (40 µL) dose of Janssen COVID-19 intramuscular injection vaccine was supplemented with a commercial selenium supplement and sodium selenite orally in BALB/c mice (N = 18). Qualitative determination of anti-spike IgG antibody response using indirect Enzyme-Linked Immunosorbent Assay (ELISA) showed significant (p ≤ 0.001) increase in anti-spike IgG antibody response for mice groups immunized with vaccine and supplemented selenium. Furthermore, cytokine profiling using real-time quantitative polymerase chain reaction also showed an increase in IL-6 and IL-10 mRNA levels normalized using hypoxanthine phosphoribosyl transferase 1 (Hprt1) and glyceraldehyde 3-phosphate dehydrogenase (Gadph) housekeeping genes. There was no statistical significance (p < 0.465) among treated and untreated groups for alanine transaminase (ALT), aspartate transaminase (AST), urea, and creatinine parameters. The study presents preliminary findings and suggests that supplementing Janssen COVID-19 vaccines with selenium can generate more robust immune responses.

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Section: Discussionsupporting

confidence: 79%

Preliminary In Vivo Evidence of Oral Selenium Supplementation as a Potentiating Agent on a Vector-Based COVID-19 Vaccine in BALB/c Mice

Mudenda¹,

Kimani

Kinyua

et al. 2022

Vaccines

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“…Their supplementations reduced the progression of HIV disease and the incidence of HIV-associated complications in infected women [89] as well as mortality in patients with Ebola virus disease [90]. The success with other viral infections has led to the proposal to use them in the treatment of COVID-19 patients [87,91]. These micronutrient supplements also reduced the incidence of clinical malaria [92,93], improved anti-malarial parameters and survival [94] and improved recovery in influenza [95].…”

Section: Micronutrient Supplements For Communicable and Non-communica...mentioning

confidence: 99%

Exploring micronutrient supplements in disease conditions: are they effective?

Ekong,

Nwakanma,

Iniodu

2024

FNDS

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Nutrition is essential for the health and well-being of all living beings and is sourced from foods of different origins and types. Most importantly, the food must contain carbohydrates, proteins, fat, vitamins and minerals in a balanced form to achieve optimum benefits. Vitamins and minerals, also known as micronutrients, are characterised by their nature, quantity and role in normal metabolic activities. In humans, micronutrients are exclusively obtained from food or supplements. In addition, vitamin D3 is synthesized de novo with the aid of sunlight, while vitamins B and K are synthesized in the gut by the resident bacteria. Micronutrients play an important role in health and disease states and have become the most widely used dietary supplements in the world. However, how effective they are against diseases is controversial as conflicting reports continue to emerge, especially where insufficient data is available. This review highlights the important role of micronutrient supplements in the alleviation of communicable and non-communicable diseases. Data were retrieved from the literature in databases including African Journal Online, Google Scholar, PubMed and Web of Science, among others, with hits on nutrients, vitamins and mineral supplements: Only literature with relevant information from 1993-2023 (30 years) was considered. As important as these micronutrients are for health and their supplementations are generally beneficial, it is worthy of note that their role in the disease treatment is still limited by insufficient data.

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Supplementation of Micronutrients against COVID-19

Cited by 2 publications

References 28 publications

Preliminary In Vivo Evidence of Oral Selenium Supplementation as a Potentiating Agent on a Vector-Based COVID-19 Vaccine in BALB/c Mice

Preliminary In Vivo Evidence of Oral Selenium Supplementation as a Potentiating Agent on a Vector-Based COVID-19 Vaccine in BALB/c Mice

Exploring micronutrient supplements in disease conditions: are they effective?

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