Supplementation of omega-3 fatty acids with aripiprazole and lithium lessens methylphenidate induced manic behavior in Swiss albino mice

Arunagiri, Pandiyan; Rajeshwaran, K.; Shanthakumar, Janakiraman; Balamurugan, Elumalai

doi:10.1016/j.phanu.2013.11.128

Cited by 6 publications

(2 citation statements)

References 55 publications

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“…Therefore, there is increasing interest in using natural antioxidants to diminish the genotoxicity of nanoparticles. Omega-3 is safe and non-genotoxic as the oral administration of omega-3 for three consecutive days did not cause any change in the integrity of the genomic DNA, PCR-SSCP pattern of the mitochondrial D-loop fragments P1 and P2 and oxidative stress markers in a line with previous studies (El-Ansary et al 2011;Kumar et al 2011;Elelaimy et al 2012;Arunagiri et al 2014).…”

Section: Discussionsupporting

confidence: 88%

“…docosahexaeonoic acid (DHA) and eicosapentaennoic acid (EPA). Thus, restoring the structural integrity of the genomic DNA and the normal oxidative status by simultaneous co-administration of omega-3 with CoO-NPs could be attributed to the omega-3 fatty acids DHA and EPA acting as antioxidants which scavenge ROS and also provide the building blocks for healthy cell membranes (Le-Niculescu et al 2011;Arunagiri et al 2014).…”

Section: Discussionmentioning

confidence: 99%

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Amelioration of cobalt oxide nanoparticles induced genomic and mitochondrial DNA damage and oxidative stress by omega-3 co-administration in mice

Mohamed

Hussien

2018

Caryologia

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Increased human exposure to cobalt oxide nanoparticles (CoO-NPs) because of their widespread use in many industrial and medical applications makes the study of genotoxicity and mutagenicity necessary. Therefore, this study was conducted to assess the genomic and mitochondrial DNA damage induction by CoO-NPs and the possible protective role of omega-3 in mice. The simultaneous administration of omega-3 significantly reduced DNA damage caused by CoO-NPs, which was evaluated by restoring the normal intact appearance of genomic DNA running on the agarose gel and normalizing fractionated DNA. The elevated malondialdehye (MDA) level and the reduced catalase (CAT) and glutathione peroxidase (Gpx) activities by CoO-NPs oral administration were normalized by omega-3 co-administration. Moreover, the omega-3 co-administration reduced the incidence of mutations induced by CoO-NPs in mitochondrial D-loop from 67% to 33%. We concluded that genomic and mitochondrial DNA damage and oxidative stress caused by CoO-NPs was mitigated by omega-3 co-administration.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Amelioration of cobalt oxide nanoparticles induced genomic and mitochondrial DNA damage and oxidative stress by omega-3 co-administration in mice

Mohamed

Hussien

2018

Caryologia

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Therapeutic approaches employing natural compounds and derivatives for treating bipolar disorder: emphasis on experimental models of the manic phase

et al. 2021

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Combination of Omega-3 Fatty Acids, Lithium, and Aripiprazole Reduces Oxidative Stress in Brain of Mice with Mania

Arunagiri

Rajeshwaran

Shanthakumar

et al. 2014

Biol Trace Elem Res

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Manic episode in bipolar disorder (BD) was evaluated in the present study with supplementation of omega-3 fatty acids in combination with aripiprazole and lithium on methylphenidate (MPD)-induced manic mice model. Administration of MPD 5 mg/kg bw intraperitoneally (i.p.) caused increase in oxidative stress in mice brain. To retract this effect, supplementation of omega-3 fatty acids 1.5 ml/kg (p.o.), aripiprazole 1.5 mg/kg bw (i.p.), and lithium 50 mg/kg bw (p.o) were given to mice. Omega-3 fatty acids alone and in combination with aripiprazole- and lithium-treated groups significantly reduced the levels of superoxide dismutase (SOD), catalase (CAT), and lipid peroxidation products (thiobarbituric acid reactive substances) in the brain. MPD treatment significantly decreased the reduced glutathione (GSH) level and glutathione peroxidase (GPx) activity, and they were restored by supplementation of omega-3 fatty acids with aripiprazole and lithium. There is no remarkable difference in the effect of creatine kinase (CK) activity between MPD-induced manic model and the treatment groups. Therefore, our results demonstrate that oxidative stress imbalance and mild insignificant CK alterations induced by administration of MPD can be restored back to normal physiological levels through omega-3 fatty acids combined with lithium and aripiprazole that attributes to effective prevention against mania in adult male Swiss albino mice.

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Supplementation of omega-3 fatty acids with aripiprazole and lithium lessens methylphenidate induced manic behavior in Swiss albino mice

Cited by 6 publications

References 55 publications

Amelioration of cobalt oxide nanoparticles induced genomic and mitochondrial DNA damage and oxidative stress by omega-3 co-administration in mice

Amelioration of cobalt oxide nanoparticles induced genomic and mitochondrial DNA damage and oxidative stress by omega-3 co-administration in mice

Therapeutic approaches employing natural compounds and derivatives for treating bipolar disorder: emphasis on experimental models of the manic phase

Combination of Omega-3 Fatty Acids, Lithium, and Aripiprazole Reduces Oxidative Stress in Brain of Mice with Mania

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