Supplementation of omega‐3 fatty acids in patients with ankylosing spondylitis

Sundström, Björn; Stålnacke, K.; Hagfors, Linda; Johansson, Gunnar

doi:10.1080/03009740600844357

Cited by 30 publications

(22 citation statements)

References 10 publications

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“…Description of the included studies and participants Multiple studies were conducted in Sweden and United Kingdom, and individual studies in Norway, Belgium, France, Australia, New Zealand, China, Portugal, and Turkey (Table 1, Appendix 1) and were published between 1991 and 2014 (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(37)(38)(39)(40). Seven of the included studies were case series; three were treatment outcome studies with all the participants receiving intervention, three were randomized clinical trials, one was a case-control study, and one study investigated the gene-environment interaction using a case-only design (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(37)(38)(39)(40).…”

Section: Search Resultsmentioning

confidence: 99%

“…Seven of the included studies were case series; three were treatment outcome studies with all the participants receiving intervention, three were randomized clinical trials, one was a case-control study, and one study investigated the gene-environment interaction using a case-only design (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(37)(38)(39)(40). All of the studies were conducted in a hospital setting, except one study that recruited participants via a Web site (Table 1, Appendix 1) (28).…”

Section: Search Resultsmentioning

confidence: 99%

“…Among the 11 studies that reported gender distribution, females comprised between 19% and 38% (27,31). Among the 10 studies that reported age distribution, the mean age ranged between 30 and 50 years (31,32).…”

Section: Search Resultsmentioning

confidence: 99%

“…The following criteria were used to measure disease activity: the Bath Ankylosing Disease Activity Index (BASDAI) (9 studies), Bath Ankylosing Functional Index (BASFI) (7 studies), Bath AS Patient Global Score (BASG) (3 studies), AS Quality of Life (ASQoL) index (2 studies), ASAS, and ASAS20 (one study), SF-36 (2 studies), erythrocyte sedimentation rate (ESR) (5 studies), C-reactive protein (CRP) (5 studies), aggravation of symptoms, change from baseline, visual analog scale (VAS), and medication requirement ( Table 1, Appendix 2) (25,27,30,32,35,36,(45)(46)(47)(48)(49)(50)(51).…”

Section: Search Resultsmentioning

confidence: 99%

“…After further consideration, 3 abstracts were removed because they did not include the necessary information and 46 full-text articles were removed because they did not report AS (n=3), did not look at relationship between AS and diet (n=2), included children (n=1), had a very small sample of AS patients (n=4), contained case reports (n=3), did not report information on diet (n=1), was in the Chinese language (n=1), did not report diet (n=25), did not report information on AS (n=2), and were non-systematic reviews (n=3) and thesis (duplicate publication, n=1). There were a total of 16 studies included in the review, 10 of which were full-text papers, two were letters, two studies were summarized in review articles, and two were conference abstracts (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40).…”

Section: Search Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Relationship between diet and ankylosing spondylitis: A systematic review

Macfarlane¹,

Abbood²,

Pathan³

et al. 2018

Eur J Rheumatol

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The question of whether diet plays a role in the onset of ankylosing spondylitis (AS) or can affect the course of the disease is an important one for many patients and healthcare providers. The aims of this study were to investigate whether: 1) patients with AS report different diets to those without AS; 2) amongst patients with AS, diet is related to severity; 3) persons with particular diets are less likely to develop AS; 4) specific dietary interventions improve the AS symptoms. The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Medline, Embase, Cochrane Library, and reference lists of relevant articles were searched. Two authors independently selected eligible studies, assessed the quality of included trials, and extracted the data. Sixteen studies (nine observational and seven interventions) were included in the review. Due to the heterogeneity of the study designs and analyses, the results could not be aggregated. Evidence on a possible relationship between AS and diet is extremely limited and inconclusive due to the majority of included studies being small, single studies with moderate-to-high risk of bias, and insufficient reporting of results.

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Section: Search Resultsmentioning

confidence: 99%

Section: Search Resultsmentioning

confidence: 99%

Section: Search Resultsmentioning

confidence: 99%

Section: Search Resultsmentioning

confidence: 99%

Section: Search Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Relationship between diet and ankylosing spondylitis: A systematic review

Macfarlane¹,

Abbood²,

Pathan³

et al. 2018

Eur J Rheumatol

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Serum fatty acid profiles and potential biomarkers of ankylosing spondylitis determined by gas chromatography–mass spectrometry and multivariate statistical analysis

Chen

Han

Dong

et al. 2014

Biomedical Chromatography

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Ankylosing spondylitis (AS) is a common chronic inflammatory rheumatic disease. Early and accurate detection is essential for effective disease treatment. Recently, research has focused on genomics and proteomics. However, the associated metabolic variations, especially fatty acid profiles, have been poorly discussed. In this study, the gas chromatography-mass spectrometry (GC-MS) approach and multivariate statistical analysis were used to investigate the metabolic profiles of serum free fatty acids (FFAs) and esterified fatty acids (EFAs) in AS patients. The results showed that significant differences in most of the FFA (C12:0, C16:0, C16:1, C18:3, C20:4, C20:5, C22:5 and C22:6) and EFA (C12:0, C16:1, C18:0, C18:1, C18:2, C18:3, C20:4 and C22:6) concentrations were found between the AS patients and healthy controls (p < 0.05). Principal component analysis and partial least squares discriminant analysis were performed to classify the AS patients and controls. Additionally, FFAs C20:4, C12:0, C18:3 and EFAs C22:6, C12:0 were confirmed as potential biomarkers to identify AS patients and healthy controls. The present study highlights that differences in the serum FFA and EFA profiles of AS patients reflect the metabolic disorder. Moreover, FFA and EFA biomarkers appear to have clinical applications for the screening and diagnosis of AS.

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Lifestyle modification and inflammation in people with axial spondyloarthropathy—A scoping review

Roberts

Leonard

Bishop

et al. 2022

Musculoskeletal Care

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Introduction:People with axial spondyloarthritis (AS) have an inflammatory profile, increasing the risk of hypertension, type 2 diabetes, obesity, and dyslipidaemia. Consequently, AS is linked with co-morbidities such as cardiovascular disease (CVD). Physical inactivity, diet, smoking, alcohol consumption, and obesity influence inflammation, but knowledge of the interaction between these with inflammation, disease activity, and CVD risk in AS is dominated by cross-sectional research. Methods: A review of the literature was conducted between July 2020 and December 2021. The focus of the scoping review is to summarise longitudinal and randomised control trials in humans to investigate how tracking or modifying lifestyle influences inflammation and disease burden in patients with AS. Key messages: (1) Lifestyle modifications, especially increased physical activity (PA), exercise, and smoking cessation, are critical in managing AS. (2) Smoking is negatively associated with patient reported outcome measures with AS, plus pharmaceutical treatment adherence, but links with structural radiographic progression are inconclusive. (3) Paucity of data warrant structured studies measuring inflammatory cytokine responses to lifestyle modification in AS. Conclusion: Increased PA, exercise, and smoking cessation should be supported at every given opportunity to improve health outcomes in patients with AS. The link between smoking and radiographic progression needs further investigation. Studies investigating the longitudinal effect of body weight, alcohol, and psychosocial factors on disease activity and physical function in patients with AS are needed. Given the link between inflammation and AS, future studies should also incorporate markers of chronic inflammation beyond the standard C-reactive protein and erythrocyte sedimentation rate measurements.

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Supplementation of omega‐3 fatty acids in patients with ankylosing spondylitis

Abstract: Omega-3 fatty acids in adequate doses may have the capacity to decrease the disease activity of AS. However, larger and better controlled studies are needed before any further conclusions can be made on the extent of this capacity.

Cited by 30 publications

References 10 publications

Relationship between diet and ankylosing spondylitis: A systematic review

Relationship between diet and ankylosing spondylitis: A systematic review

Serum fatty acid profiles and potential biomarkers of ankylosing spondylitis determined by gas chromatography–mass spectrometry and multivariate statistical analysis

Lifestyle modification and inflammation in people with axial spondyloarthropathy—A scoping review

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