Supplementation of polar lipids‐enriched milk fat globule membrane in high‐fat diet‐fed rats during pregnancy and lactation promotes brown/beige adipocyte development and prevents obesity in male offspring

Li, Tiange; Gong, Han; Yuan, Qichen; Du, Min; Ren, Fazheng; Mao, Xueying

doi:10.1096/fj.201901867rrr

Cited by 18 publications

(18 citation statements)

References 70 publications

(149 reference statements)

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“…Besides, different interaction effects of diet and MFGM-PL supplementation were observed for body weight during pregnancy and lactation (F(1,20) = 0.14, P = .72; F(1,20) = 2.12, P = . 21 F(1,20) = 0.11, P = .75) (Figure 2C). However, HFD dams exhibited increased serum insulin levels (Figure 2D) and TG levels (Figure 2E 3A,B).…”

Section: Effects Of Mfgm-pl Supplementation On Maternal Characteristicsmentioning

confidence: 93%

Supplementation of milk polar lipids to obese dams improves neurodevelopment and cognitive function in male offspring

Yuan

Gong

et al. 2021

The FASEB Journal

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Milk contains about 4% fat globules with its surface covered by polar lipids. Despite the abundant consumption of dairy products, the biological effects of dietary milk polar lipids on metabolic health have only been sparsely examined. Maternal obesity results in neurodevelopmental disorders and cognitive impairment in offspring. Considering the importance of maternal nutrition, the effects of polar lipids-enriched milk fat globule membrane (MFGM-PL) supplementation to dams during pregnancy and lactation on neurodevelopment and its long-term programming effects on offspring cognition were examined. Female Sprague-Dawley rats consumed 8-week control diet (CON) or high-fat diet (HFD) to induce obesity before mating. Then, female rats were fed CON or HFD with or without the supplementation of 400 mg/ kg body weight MFGM-PL during pregnancy and lactation. The offspring were fed 11-week HFD after weaning. MFGM-PL supplementation to obese dams suppressed body weight gain and hyperinsulinemia in both dams and offspring. Offspring born to obese dams displayed delayed neurological reflexes development, impaired neurogenesis before weaning, and cognitive impairment in adulthood, which were recovered by maternal MFGM-PL supplementation. Insulin resistance and aberrant brain-derived neurotrophic factor signaling were induced in the hippocampus of neonatal and adult offspring due to maternal and progeny HFD, but recovered by maternal MFGM-PL administration. This study demonstrates that maternal MFGM-PL supplementation can promote neurodevelopment and exert long-term effects against HFD-induced cognitive impairment in offspring via alleviating hippocampal insulin resistance. Hence, MFGM-PL is a promising ingredient for exerting beneficial programming effects on the brain health of offspring.

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Section: Effects Of Mfgm-pl Supplementation On Maternal Characteristicsmentioning

confidence: 93%

Supplementation of milk polar lipids to obese dams improves neurodevelopment and cognitive function in male offspring

Yuan

Gong

et al. 2021

The FASEB Journal

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“…MFGM intake suppressed body weight gain induced by a high-fat diet and reduced white adipose tissue mass accompanied by the decreased adipocyte sizes in C57BL/6 mice (Li et al 2018b). Rats on a high-fat diet were given PLs enriched with MFGM (MFGM-PL) during pregnancy and lactation and the health and metabolic status of their offspring were assessed (Li et al 2020). Maternal consumption of MFGM-PL promoted the development of brown adipocytes, decreased white adipocytes and prevented obesity in male offspring.…”

Section: Obesity and Inflammationmentioning

confidence: 99%

“…Rats on a high‐fat diet were given PLs enriched with MFGM (MFGM‐PL) during pregnancy and lactation and the health and metabolic status of their offspring were assessed (Li et al . 2020). Maternal consumption of MFGM‐PL promoted the development of brown adipocytes, decreased white adipocytes and prevented obesity in male offspring.…”

Section: Nutritional and Health Benefits Of Mfgmmentioning

confidence: 99%

Milk fat globule membrane: An overview with particular emphasis on its nutritional and health benefits

El-Salam

El-Shibiny

2020

Int J of Dairy Tech

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Milk fat globule membrane (MFGM) is a minor milk constituent composed of a large number of polar lipid (PL) classes and proteins organised in a tri-layer structure. The MFGM PLs and proteins have a wide range of nutritional and health benefits. Animal and human studies have shown that consumption of MFGM preparations has beneficial effects on brain development and function and physical performance, particularly in the elderly. MFGM also improves intestinal health and skin condition, combats hypercholesterolaemia, obesity and inflammation. The present article updates the information about MFGM; particularly its nutritional and health benefits.

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“…MFGM contains large amounts of bioactive ingredients, such as unique polar lipids and membrane-specific proteins, and contributes to the growth and development of infants (Hernell et al, 2016). In a rodent model, the supplementation of polar lipid-enriched MFGM to obese dams was demonstrated to increase energy expenditure and alleviate obesity in adult offspring exposed to maternal HFD and an obesogenic environment post-weaning (Li et al, 2020). Although several groups have focused on the relationship between prenatal/ postnatal MFGM supplementation and adult metabolic health, we are committed to identifying the mechanism behind it.…”

Section: Discussionmentioning

confidence: 99%

Neonatal Milk Fat Globule Membrane Supplementation During Breastfeeding Ameliorates the Deleterious Effects of Maternal High-Fat Diet on Metabolism and Modulates Gut Microbiota in Adult Mice Offspring in a Sex-Specific Way

Zhang

Xin

et al. 2021

Front. Cell. Infect. Microbiol.

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Exposure to adverse events in early life increases the risk of chronic metabolic disease in adulthood. The objective of this study was to determine the significance of milk fat globule membrane (MFGM)-mediated alterations in the gut microbiome to the metabolic health of offspring in the long-term. Female C57BL/6 mice were fed either a high-fat diet (HFD) or a control diet for 3 weeks before pregnancy and throughout pregnancy and lactation. During lactation, pups from the HFD group were breast-fed with or without 1,000 mg/kg BW/day MFGM supplementation (HFD and HFD-MS group, respectively). After weaning, the offspring in each group were divided into male and female subgroups. The weaned mice were then shifted to a control diet for 8 weeks. At the eleventh week, stool samples were collected for 16S rRNA gene sequencing. Serum biochemical parameters were analyzed, and intraperitoneal glucose and insulin tolerance tests were performed. Neonatal supplementation with MFGM ameliorated metabolic disorder and improved glucose tolerance in offspring exposed to maternal HFD in a sex-specific manner. Furthermore, maternal HFD induced gut microbiota perturbation in offspring in adulthood. Neonatal MFGM supplementation significantly enriched g-Parabacteroides, g-Bifidobacterium, g-Faecalibaculum, and g-Lactobacillus in male offspring exposed to maternal HFD, while significantly enriched g-Parabacteroides and g-Alistipes in female offspring exposed to maternal HFD. These bacteria may be associated with the favorable changes in metabolism that occur in adulthood. Sex differences in the changes of metagenomic pathways related to oxidative phosphorylation, citrate cycle, electron transfer carries, and ubiquinone biosynthesis were also observed in the offspring. Maternal HFD has an adverse effect on the metabolism of offspring in later life. Neonatal MFGM supplementation could modulate the structure of gut microbiota communities and may have long-term protective effects on lipid and glucose metabolism, but these effects are sex dimorphic.

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Supplementation of polar lipids‐enriched milk fat globule membrane in high‐fat diet‐fed rats during pregnancy and lactation promotes brown/beige adipocyte development and prevents obesity in male offspring

Cited by 18 publications

References 70 publications

Supplementation of milk polar lipids to obese dams improves neurodevelopment and cognitive function in male offspring

Supplementation of milk polar lipids to obese dams improves neurodevelopment and cognitive function in male offspring

Milk fat globule membrane: An overview with particular emphasis on its nutritional and health benefits

Neonatal Milk Fat Globule Membrane Supplementation During Breastfeeding Ameliorates the Deleterious Effects of Maternal High-Fat Diet on Metabolism and Modulates Gut Microbiota in Adult Mice Offspring in a Sex-Specific Way

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